Shedding of infectious SARS-CoV-2 despite vaccinationArticle Published on 2022-09-302022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 치료기술, [키워드] caused concern COVID-19 COVID-19 case cycle threshold Delta delta variant determine Immune escape individual individuals Infectious virus Laboratory Mutation nasal swab no significant effect North America predominant RT-PCR SARS-CoV-2 SARS-CoV-2 vaccine Sex shedding specimen subset tested Testing vaccinated individual vaccination Vaccine [DOI] 10.1371/journal.ppat.1010876 PMC 바로가기
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recoveryArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome affected animal model change coronavirus correlated COVID COVID-19 demonstrated detectable exceeded hamster highlight host response Human IAV individual Infection Infectious virus influenza A virus Injury interferon response kidney lack lung mechanism molecular mechanism olfactory Olfactory epithelium PASC pathology Perturbation Proinflammatory cytokine response Result SARS-CoV-2 SARS-COV-2 infection sustained T cell activation tissue transcriptional change unique viral clearance [DOI] 10.1126/scitranslmed.abq3059 PMC 바로가기
A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamstersArticle Published on 2022-09-272022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Administered Antiviral effect coronavirus COVID-19 pandemic delta variant Detection limit disease dose effective Efficacy exhibited hamster hamsters highest Infectious virus Inflammatory cytokines Intervention intranasally intrinsically limit Lipid nanoparticle Lower mucosa nasal Particle Pathogenesis Postinfection Prevent reduce reduced reported respiratory tissue respiratory virus SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 transmission SARS-CoV-2 viral shedding severe disease severe lung pathology significantly lower suppress tested therapeutic therapeutic interfering particles TIP tissue Transmissibility Transmission uninfected variants variants. viral loads viral replication while [DOI] 10.1073/pnas.2204624119 PMC 바로가기
Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and BuddingArticle Published on 2022-09-202022-11-16 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] assembly budding caused cellular condensation coronavirus 2 COVID-19 pandemic curtail de novo develop drug target envelope Genome genome condensation genomic RNA host cell identify Infectious virus Interaction intrinsic M protein mechanism membranes modeling molecular Mutation N protein oligomerization pathogen Protein protein intrinsic curvature. Research respiratory responsible resulting RNA SARS-CoV-2 spike structural protein structural proteins the S protein therapeutic target therapy Vaccines viral entry viral life cycle viral particle virus while [DOI] 10.3390/v14102089 PMC 바로가기
Vaccination Decreases the Infectious Viral Load of Delta Variant SARS-CoV-2 in Asymptomatic PatientsArticle Published on 2022-09-182022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] affecting Anti-spike asymptomatic infection asymptomatic infections B.1.617.2 breakthrough Breakthrough infection caused collected COVID-19 decrease Delta delta variant IgA individual Infectious virus load nasal Nasopharyngeal swab nasopharyngeal swabs other variants patients quantified risk SARS-CoV-2 secretion significantly higher Symptomatic patients Transmission vaccinated individuals vaccination vaccination. Vaccine vaccinee Viral load Viral RNA viral RNA genome while [DOI] 10.3390/v14092071 PMC 바로가기
The Omicron Variant BA.1.1 Presents a Lower Pathogenicity than B.1 D614G and Delta Variants in a Feline Model of SARS-CoV-2 InfectionArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 치료기술, [키워드] addition B.1 B.1.1.529 B.1.617.2 body temperature cats clinical COVID-19 D614G death Delta delta variant disease severity distribution effective Evidence evidenced histologic Hospitalization immunization immunofluorescence increased risk Infection infections Infectious virus Inflammation inoculated less lethargic log Lower lung Lung pathology Mild Model mutated nasal nasal turbinate observation omicron Pathogenesis pathogenic pathogenicity Pneumonia Postinfection present reduced remained Replication SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant secretion significant increase South Africa Spread staining suggested susceptible TCID tissue tissue tropism variant Variant of concern. variants Viral load viral replication Viral RNA viral titer Viral variants Virological virulence virus virus [DOI] 10.1128/jvi.00961-22 PMC 바로가기
Infectious viral shedding of SARS-CoV-2 Delta following vaccination: A longitudinal cohort studyArticle Published on 2022-09-122022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료기술, [키워드] 95% CI Adults analyzed correlated Delta enrolled faster infections infectious titer Infectious virus longitudinal cohort study median nasal no difference participant Probability reduced RNA SARS-CoV-2 SARS-CoV-2 RNA specimen stratified symptom onset tested the median vaccination Viral RNA shedding viral shedding was reduced while [DOI] 10.1371/journal.ppat.1010802 PMC 바로가기
Detection of Higher Cycle Threshold Values in Culturable SARS-CoV-2 Omicron BA.1 Sublineage Compared with Pre-Omicron Variant Specimens – San Francisco Bay Area, California, July 2021-March 2022Article Published on 2022-09-092022-11-15 Journal: Morbidity and Mortality Weekly Report [Category] SARS, 변종, 치료기술, [키워드] Analysis Area B.1.1.529 cause CDC Cohort collected COVID-19 Culture cycle cycle threshold demonstrated detection generate Guidance in viral Infection infections Infectious virus marker nasal omicron participant positive public health reliability remains uncertain Research RNA RT-PCR San Francisco Bay SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 variant SARS-CoV-2 variants specimen Supporting These data unlikely value variant variant of SARS-CoV-2 Viral RNA virus were used [DOI] 10.15585/mmwr.mm7136a3 PMC 바로가기
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 modelArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] Activation animal model antiviral property ciliated cells COVID-19 disease epithelial Factor FG-4592 Host hypoxia hypoxic identify increased expression Infection Infectious virus inhibit SARS-CoV-2 inhibitor intrinsic Lower respiratory tract lung epithelia microenvironment nucleocapsid expression pathological analysis pathway provide reduced reduction in regulate respiratory pathogen respiratory symptom SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA significantly susceptibility therapeutic Therapies transcriptional treated understanding virus replication [DOI] 10.1371/journal.ppat.1010807 PMC 바로가기
Frequent detection but lack of infectivity of SARS-CoV-2 RNA in presymptomatic, infected blood donor plasmaArticle Published on 2022-09-012022-11-15 Journal: The Journal of Clinical Investigation [Category] SARS, 치료기술, [키워드] Blood blood donor cell line clinical Clinical practice cough COVID-19 COVID-19 mortality COVID-19 patient detectable detection Diagnosis diagnosis of COVID-19 Donor General population implementation Infectious virus Influenza information lack less Limits of detection mice Mild Molecular diagnosis. Pathogenesis PDI peaked plaque-forming unit plasma presymptomatic produced question raise reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe symptoms Shortness of breath susceptible Symptom tested unlikely vaccination virus widespread [DOI] 10.1172/JCI159876 PMC 바로가기