Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening Research Published on 2022-08-092022-10-05 Journal: Nature Communications [Category] 임상, 진단, [키워드] adaptive attenuate Bacteria CD169 cytokine degrade deplete detrimental downstream effector fungi G-CSF histone hyperinflammation hyphae immature immune dysfunction Immunity induce Infection infiltration Macrophage macrophages mechanism mechanism of action microbial Mortality myeloperoxidase neutralize neutrophil oxidative burst pathogen pathology Patient patient mortality phagocytic plasma promote receptor receptors Sepsis T cell Trigger zone [DOI] 10.1038/s41467-022-32320-1 [Article Type] Research
Autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination: case report and literature review코로나19 예방접종으로 촉발된 HCV 치료 이력이 있는 자가면역 간염: 증례 보고 및 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Clinical journal of gastroenterology [Category] 치료제, [키워드] administration antibody Autoimmune diseases Autoimmune hepatitis Blood Case report Cell coronavirus disease COVID-19 COVID-19 vaccination described diagnosed direct-acting antiviral Direct-acting antivirals effective elevated HCV HCV antibody Hepatitis hepatitis C hepatitis C virus hospital IgG infiltration interface literature review Liver injury plasma Plasma cell positive real-time RT-PCR referred to RNA SARS-CoV-2 steroid Treatment triggered vaccination Vaccine worldwide pandemic [DOI] 10.1007/s12328-022-01654-0 PMC 바로가기 [Article Type] Review
Platelets in the NETworks interweaving inflammation and thrombosis염증과 혈전을 뒤섞는 NETworks의 혈소판Review Published on 2022-08-012022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] activate Bacterial Capillaries capillary characterized chemokine chemokines chromatin Clinical outcome Coagulation factors contribute contributing to Course COVID-19 COVID-19 pandemic COVID-19 patient Cytokine storm disease DNA engage ENhance Evidence expression Extracellular extracellular space Growth factors hemorrhage Hemostasis histone Histones host innate immunity immune response immunothrombosis IMPROVE increased mortality induce infiltration Inflammation Inflammatory diseases inflammatory signaling Interaction interface kill lesion lung majority mechanism microthrombi molecular mechanism NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil infiltration Neutrophils other tissue other tissues pathogen Pathogens Pathways Patient Pattern recognition Pattern recognition receptors Platelet Platelets procoagulant Protein Proteins provide provided resulting signaling pathway subsequent surface expression survival target thrombi thrombosis thrombotic TLR2 TLR4 Topic TRAP Treatment vascular beds virus [DOI] 10.3389/fimmu.2022.953129 PMC 바로가기 [Article Type] Review
COVID-19 related acute necrotizing encephalopathy with extremely high interleukin-6 and RANBP2 mutation in a patient with recently immunized inactivated virus vaccine and no pulmonary involvement최근 면역 불활화 바이러스 백신을 접종하고 폐 침범이 없는 환자에서 매우 높은 인터루킨-6 및 RANBP2 돌연변이를 갖는 COVID-19 관련 급성 괴사성 뇌병증Case Reports Published on 2022-07-232022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Acute kidney injury Acute necrotizing encephalopathy ADE affecting alteration Analysis antibody blood pressure blood-brain barrier body temperature bpm Brain caused Celsius characteristic Chest Chest radiograph Clinical course Coma Computerized tomography consciousness COVID-19 COVID-19 vaccine cytokine cytokine signaling Cytokine storm Cytokines delta variant Encephalopathy examination Factor gene analysis heart rate hemorrhage hepatic failure heterozygous Hypothesis IL-6 immune response immunized inactivated Inactivated vaccine incidence of COVID-19 infiltration interleukin-6 lesion minute Missense mutation mitochondrial Mitochondrial function Mutation Necrosis oxygen oxygen saturation Pathogenesis Patient Potential treatment predictor preserved Previous studies Prognostic factor pulmonary disease pulmonary involvement pyelonephritis Ranbp2 RANBP2. reported respiratory respiratory rate role SARS-CoV-2 SARS-CoV2 infection Seizure Septic shock Sequencing Serum IL-6 Sinopharm Stupor Vaccine viral entry virus whole genome Whole genome sequencing [DOI] 10.1186/s12879-022-07610-0 PMC 바로가기 [Article Type] Case Reports
Efficacy of salmeterol and magnesium isoglycyrrhizinate combination treatment in rats with chronic obstructive pulmonary disease Research Published on 2022-07-192022-10-05 Journal: Scientific Reports [Category] 바이오마커, 치료제, [키워드] Adverse reaction airway Anti-inflammatory Bronchoalveolar lavage fluid characterized chronic inflammation chronic obstructive Clinical treatment Combination combination treatment contributing to COPD glucocorticoid Hormones IL-1β IL-6 infiltration inflammatory cell involved JAK/STAT signaling pathway Lung function Lung inflammation Lymphocytes Magnesium isoglycyrrhizinate mechanism MUC5AC neutrophil Patient propionate pulmonary disease receptor reduced salmeterol xinafoate secretion serum steroidal anti-inflammatory drugs suggested TNF-α Treatment White blood cells [DOI] 10.1038/s41598-022-16775-2 [Article Type] Research
Natural killer cell homing and trafficking in tissues and tumors: from biology to application Reviews Published on 2022-06-292022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] Affect Allogeneic Alter blood circulation Bone marrow Cancer Cancer immunotherapy cancer treatment cancers CAR cells cellular chemokine chemokine receptors chimeric antigen receptor clinical utility cytokine Cytokines Defense develop Evidence Ex vivo expansion Factor Factors homing Immunotherapy IMPROVE infiltration Innate lymphoid cells Integrins limit lymphoid organs lymphoid tissues mechanism microenvironment natural natural killer cell NK cell peripheral tissues profile receptors solid tumors Steady state subset tissue transcriptional transfer transferred Treatment [DOI] 10.1038/s41392-022-01058-z [Article Type] Reviews
The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from WuhanDelta SARS-CoV-2 변종은 우한의 조상 균주와 비교하여 K18-hACE2 형질전환 마우스에서 호흡기 질환의 뚜렷한 병원성 패턴을 유도합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis B cells Brain caused CD45 Cell cells clinical disease concern coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Cytokines Delta delta variant dendritic cell dendritic cells disease dissemination hACE2 help Immune escape immune response Increased Infection infiltration Inflammatory inflammatory monocytes intestinal wall intestine K18-hACE2 K18-hACE2 mice K18-hACE2 transgenic mice kidney lung Lungs manifestation mice Monocytes mouse model multiple tissues no significant difference observation Pathogenesis pathogenicity pattern perivascular inflammation Proinflammatory cytokine proinflammatory cytokines provide respiratory SAME AS SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe COVID-19 shown significant difference significantly lower strain T cells the disease therapeutic intervention therapeutic interventions Therapies tissue damage tissue pathology Transmissibility Treatment strategies two groups variant Wuhan [DOI] 10.1128/mbio.00683-22 PMC 바로가기 [Article Type] Article
C1R, CCL2, and TNFRSF1A Genes in Coronavirus Disease-COVID-19 Pathway Serve as Novel Molecular Biomarkers of GBM Prognosis and Immune Infiltration코로나바이러스 질병-COVID-19 경로의 C1R, CCL2 및 TNFRSF1A 유전자는 GBM 예후 및 면역 침투의 새로운 분자 바이오마커 역할을 합니다Article Published on 2022-06-182022-09-11 Journal: Disease Markers [Category] MERS, 바이오마커, 진단, [키워드] Analysis Bioinformatics analysis Biomarker Brain Brain tumor CCL2 Cell coronavirus coronavirus disease correlation database DEGs differentially expressed gene Early detection experiment expression expression level expression levels glioblastoma multiforme identify Immune cell Immune cell infiltration immune cells immune infiltration immune response indicated infiltration involved KEGG molecular mRNA expression novel pathway Pathways Patient patients prevalent Prognosis proportion protein-protein interaction significant difference significantly survival tissue TNFRSF1A Treatment Tumor used data [DOI] 10.1155/2022/8602068 PMC 바로가기 [Article Type] Article
Pyronaridine Protects against SARS-CoV-2 Infection in Mouse파이로나리딘은 마우스의 SARS-CoV-2 감염으로부터 보호합니다Article Published on 2022-06-102022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Antiviral antiviral activity antiviral drug antiviral drugs approved assist Cell cells chemokine coronavirus COVID-19 demonstrated Ebola Efficacy evaluated in vitro in vivo infiltration inhibit SARS-CoV-2 inhibited involved K18-hACE lung Lung pathology Lungs M pro mice molecular mechanism mouse pro-inflammatory pro-inflammatory cytokines pyronaridine reducing reduction in Remdesivir Replication respiratory Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory coronavirus Spike protein statistically significant reduction structure activity relationship the SARS-CoV-2 therapeutic Transgenic mouse Treatment Viral Viral load [DOI] 10.1021/acsinfecdis.2c00091 PMC 바로가기 [Article Type] Article
Targeting of Glycosaminoglycans in Genetic and Inflammatory Airway Disease유전 및 염증성 기도 질환에서 글리코사미노글리칸의 표적화Review Published on 2022-06-082022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] addition airway alveolar epithelium Asthma Cell cell differentiation chronic obstructive chronic obstructive pulmonary disease contribute COVID-19 COVID-19 pandemic cystic fibrosis described Diseases ECM Endothelium Extracellular matrix fibrosis glycosaminoglycan glycosaminoglycans Immune cell infiltration Inflammation Inflammatory Interaction interstitial involved lung Migration molecular interaction pathology pathophysiological role pulmonary disease receptor Research Respiratory disease targeting therapeutic agents tissue wound healing [DOI] 10.3390/ijms23126400 PMC 바로가기 [Article Type] Review