Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model인간 만능 줄기 세포 유래 모델에서 SARS-CoV-2 감염에 대한 대식세포 아형의 차등 효과Article Published on 2022-04-192022-09-12 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] ACE2 antibody Apoptosis cell type cells co-culture contribute coronavirus disease-2019 COVID-19 COVID-19 disease severity Effect effective ENhance growth host-pathogen interaction immune response Inflammatory factor inhibition inhibitory effect Interaction involved lung lung cells M2 macrophages Macrophage macrophage phenotypes macrophages pluripotent stem cell progression SARS-COV-2 infection significantly subtype suppress the SARS-CoV-2 virus Therapeutic strategies up-regulate viral entry viral infection [DOI] 10.1038/s41467-022-29731-5 PMC 바로가기 [Article Type] Article
Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at midgestation highlights the defective impacts on foetal health중태기에 감염된 COVID-19 임산부의 태반 세포 및 분자 지도는 태아 건강에 대한 결함 있는 영향을 강조합니다Article Published on 2022-04-012022-09-12 Journal: Cell Proliferation [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Activation addition age-matched control Antiviral association asymptomatic infection Blood Care CD8 T cells cellular and molecular complement Course COVID-19 COVID-19 case COVID-19 pandemic cured demonstrated exhibited expression follow-up study Genes gestation Health highlight histological immune immune activation Impact infective infective course Inflammatory Inflammatory factor Inflammatory response macrophages material midgestation Mild molecular outcome performed Placenta placental insufficiency Placentas Pregnant woman pregnant women rupture SARS-CoV-2 SARS-COV-2 infection scRNA-seq ScRNA-seq analysis Single-cell RNA sequencing single-cell RNA sequencing. tissue uterine Week [DOI] 10.1111/cpr.13204 PMC 바로가기 [Article Type] Article
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘Article Published on 2022-03-012022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제, [키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting [DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response Research Published on 2022-01-252022-10-05 Journal: Nature Aging [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] administration bronchial organoids caused CDKN2A Cell cellular senescence COVID-19 cytokine production described detectable Express expression human cell Infection Inflammation Inflammatory factor Inflammatory response involved lung marker mechanism mice mouse-adapted strain paracrine Patient persist phenotype reduced report SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell SASP senescent cell sustained syndrome Trigger undetectable uninfected cell virus [DOI] 10.1038/s43587-022-00170-7 [Article Type] Research
Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes순환 면역 세포 및 가용성 매개체의 통합 분석Research Paper Published on 2022-01-012022-09-10 Journal: Theranostics [Category] 바이오마커, [키워드] activated activating adaptive addition Analysis analysis analyzed asymptomatic infection Blood caused CCL2 CCL8 CD8+ Cell cellular chemokine chemokines circulating clinical manifestation clinical manifestations Clinical outcome Clustering cold-like symptom cold-like symptoms complex comprehensive analysis coronavirus disease Coronavirus disease 2019 correlated COVID19 COVID19 patient COVID19 patients Critical care CXCL10 CXCL9 Cytokines deregulated disease disease course disease severity exacerbated experimental variable expressing expression Extracellular Frequency GzmA GzmB healthy donors heterogeneous Hospital admission Hospitalization Host immune response IFNα IL18 IL1RA IL2 IL31 IL36B immune immune response immune signature immunological IMPROVE Infection Inflammation Inflammatory cytokine Inflammatory cytokines Inflammatory factor LAG3 Ligand ligands MIC Mild monocyte Monocytes Multivariate analysis NK cell NK cells NKG2D organ damage Patient PD1 predict Prognosis receptor reduction respiratory respiratory tract infection Respiratory tract infections reveal risk of death SARS-CoV-2 Sepsis Severe case similarity subset TNFα ULBP utility variety [DOI] 10.7150/thno.63463 PMC 바로가기 [Article Type] Research Paper
Immunological effects of convalescent plasma therapy for coronavirus: a scoping reviewResearch Article Published on 2021-12-242022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] adaptive Adaptive immune response Analysis antibody Antibody Response Antigen article Characteristics Clinical improvement conducted convalescent plasma Convalescent plasma therapy coronavirus COVID-19 CP infusion database decrease Effect Effectiveness Efficacy evaluate evaluated Evidence identify immune Immunological response in viral inclusion criteria increase in Inflammatory Inflammatory cytokine Inflammatory factor Inflammatory response leukocyte neutrophil outcome Patient patients plasma therapy reported Research Result Safe searched survival therapy viral infection Viral load [DOI] 10.1186/s12879-021-06981-0 PMC 바로가기 [Article Type] Research Article
Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19Pharmacology Published on 2021-11-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE analyzed Anti-inflammation Antiviral binding Cell Characteristics Chinese clinical symptom clinical trials component Coronavirus disease 2019 COVID-19 dry cough Effects expected Fever glycyrrhizin immunomodulatory effects IMPROVE Inflammatory factor inflammatory mediator inhibit interfere licorice mechanism of action mechanisms Mild moderate molecular mechanism outbreak pandemic pathogenesis of COVID-19 pathway Patient pharmacological Pharmacological Effects Potential Prevent respiratory diseases Shortness of breath significant difference significantly stimulated suggested Symptoms target therapeutic Topic Traditional traditional uses treat Treatment type I interferon Vaccine virus spike protein [DOI] 10.3389/fphar.2021.719758 PMC 바로가기 [Article Type] Pharmacology
Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections가벼운 SARS-COV-2 감염 환자의 순환 백혈구에 대한 지속적인 변화Comparative Study Published on 2021-11-082022-09-01 Journal: Viruses [Category] MERS, SARS, 바이오마커, 진단, [키워드] activated Asymptomatic asymptomatic infection C-reactive protein cellular change changes in Chemokine receptor chemokine receptors circulating consequence COVID-19 elevated expression Health immune activation Immune phenotype immunophenotype individual Infection Inflammation Inflammatory factor inflammatory factors investigated Mild mild or asymptomatic infections mild respiratory mild SARS-CoV-2 infection monocyte Monocyte activation persist phenotype polyclonal stimulation Post-infection post-symptom onset respiratory respiratory infections SARS-CoV-2 SARS-CoV-2 infections severe SARS severe SARS-CoV-2 significantly more survivor symptom onset systemic inflammation T-cell T-cells These data [DOI] 10.3390/v13112239 PMC 바로가기 [Article Type] Comparative Study
Neuroimmune multi-hit perspective of coronaviral infectionReview Published on 2021-10-132022-10-30 Journal: Journal of Neuroinflammation [Category] COVID-19, MERS, [키워드] ACE2 Anxiety Brain Central nervous system CNS cognitive consequence contribute contributing to Coronaviral COVID-19 pandemic COVID19 Critical Dementia Depression determine Diseases disorder Evidence Factors Genetic global pandemic illnesses individuals Infection Inflammatory factor loneliness microbial infection microglia microglial neurodegeneration neurodegenerative neuronal processe outcome Perspective psychological stressors Psychosocial stress severity Stress Stressor Support Viral virus [DOI] 10.1186/s12974-021-02282-0 PMC 바로가기 [Article Type] Review
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alterationSARS-CoV-2는 밀착 접합 변경 없이 기저막 파괴와 함께 혈액-뇌 장벽을 통과합니다.Article Published on 2021-09-062022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 치료기술, 치료제, [키워드] accompanied Activation administration astrocytes basement membrane blood-brain barrier Blood–brain barrier Brain brains collagen cross Endothelial cell endothelial cells Evan Evans blue Evidence Experimental models of disease expression hACE2 hamster Human in vitro in vivo experiments infect Inflammatory factor inflammatory factors Inflammatory response Inflammatory responses K18-hACE2 transgenic mice marker membrane MMP9 not altered occludin occurred pathway perivascular permeability reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA tight junction tight junctions transcellular pathway ultrastructure upregulated Vascular Vasculitis vessel was increased ZO-1 [DOI] 10.1038/s41392-021-00719-9 PMC 바로가기 [Article Type] Article