Robust neutralizing antibody response to SARS-CoV-2 mRNA vaccination in adolescents and young adults with childhood-onset rheumatic diseasesArticle Published on 2022-11-022022-11-15 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, 치료기술, [키워드] adverse event childhood-onset rheumatic disease Chinese Cohort COVID-19 COVID-19 infection cPass™ cut-off defined disease Disease activity dose Efficacy evaluate female first vaccination humoral immunogenicity immunogenicity increased the risk inhibition median medication Most patient mounted mRNA vaccination mRNA vaccine neutralization Neutralizing antibodies Neutralizing antibody response neutralizing response not affect Paediatric age paediatric rheumatology Patient positive predictor proportion remained response rheumatic disease SARS-CoV-2 SARS-CoV-2 vaccine second vaccination Serious Adverse Event serious complication Seven subgroup analysis symptomatic the SARS-CoV-2 the vaccine two-dose regimen vaccination Vaccine vaccine efficacy vaccine safety were assessed [DOI] 10.1093/rheumatology/keac105 PMC 바로가기
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2Article Published on 2022-10-282023-07-10 Journal: Biochemical Journal [Category] COVID19(2023년), [키워드] COVID-19 EDTA inhibition metal ions Papain-like protease SARS-CoV-2 [DOI] 10.1042/BCJ20220380
Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated IndividualsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE2 ACE2 binding analyzed Angiotensin converting enzyme-2 Anti-RBD IgG Anti-spike anti-spike antibody anti-Spike IgG antibody binding blood collection BNT162b2 calculated collected Concentration correlated correlation correlation coefficient correlation coefficients COVID-19 COVID-19 antibody demonstrated dosing interval examined Fisher group groups IgG individual inhibition interval intervals labor-intensive measure mRNA mRNA-1273 vaccines Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers NTD Participants performed RBD Sample SARS-CoV-2 Secondary analyses Spearman correlation coefficient subgroup tested the median the vaccine titer vaccinated individual vaccination Vaccine vaccinee vaccinees Validity viral neutralization wild-type with COVID-19 women [DOI] 10.1128/spectrum.01315-22 PMC 바로가기
Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling PathwayArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogate activated addition bind binding biological significance cellular processe complex disrupt DNA Epigenetic Evidence expression favor Gene Expression HDAC2 Host host antiviral response IFN response IFN signaling pathway IFN-stimulated genes IFNβ IL-1β IL-6 immune response gene inhibit inhibition inhibitory interact Interaction interferons involved IRF3 nsp5 over Pathogenesis pathway promote promoter promoters protease Protease activity protein interaction protein-protein interactions reduce Regulation Replication repress required RNA SARS-CoV-2 SARS-CoV-2 protein Signaling signaling pathway significantly subset Type Type I IFN Type I IFN signaling type I interferon viral infection viral infections Viral protein virus [DOI] 10.1128/spectrum.02322-22 PMC 바로가기
Inhibition of the Cell Uptake of Delta and Omicron SARS-CoV-2 Pseudoviruses by N-Acetylcysteine Irrespective of the Oxidoreductive EnvironmentArticle Published on 2022-10-212022-11-16 Journal: Cells [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2-expressing cell ACE2-expressing cells addition Affect alteration angiotensin-converting enzyme 2 antioxidant approach ascorbic acid binding Cell cell internalization cell receptor Comorbidities COVID-19 Delta dose-dependent Effect Effects Environment evaluated hydrogen peroxide inhibit inhibited inhibition mechanism N-acetyl-L-cysteine N-acetylcysteine NAC omicron Oxidant pharmacological Previous studies produced pseudovirus reactive oxygen species reactive oxygen specy respiratory viral infection risk ROS SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike therapy uptake variant variants variants of SARS-CoV-2 virus uptake [DOI] 10.3390/cells11203313 PMC 바로가기
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Comparative Assessment of the Inhibitory Potential of the Herbicide Glyphosate and Its Structural Analogs on RGD-Specific Integrins Using Enzyme-Linked Immunosorbent AssaysArticle Published on 2022-10-172022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation AMPA assessment binding biochemical Cell Comparative demonstrated derivative ECM ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Extracellular matrix fibrinogen glycoprotein glyphosate Herbicide ingredient inhibition inhibitory effect integrin Integrins integrins αVβ3 metabolite metabolites pathway physiological functions Polymer Potential Protein Receptor binding domain SARS-CoV-2 receptor SARS-COV-2 receptor binding domain Spike protein structural analogs the SARS-CoV-2 Total α5β1 αllbβ3. [DOI] 10.3390/ijms232012425 PMC 바로가기
Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteinsArticle Published on 2022-10-112022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence acute respiratory syndrome Affect Amino acid Antigen Antigen presentation biological activity caused CD8 Cell complex Coronavirus-2 Cytotoxic T cells dissemination down-regulation downregulating Endoplasmic reticulum expressed histocompatibility complex human populations immune responses Immunity induce infected with SARS-CoV-2 Infection inhibited inhibition mechanism MHC-I MHC-I down-regulation ORF7a orf7a protein peptide Peptide loading complex persistence physically prevented reduced sarbecovirus SARS-CoV SARS-CoV-2 T cells variety viral peptide Viral proteins [DOI] 10.1073/pnas.2209042119 PMC 바로가기
SARS-CoV-2 Papain-Like Protease: Structure, Function and InhibitionArticle Published on 2022-10-062022-11-15 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral agent antiviral immune response antivirals coronavirus COVID-19 derivatives Epidemic function Host immune response immune immune response in viral inhibition involved ISG15 less MERS-CoV motif other coronaviruses Papain-like protease posttranslational modifications protease protease inhibitors Replication SARS-CoV-1 SARS-CoV-2 Structure targets variants of concern variants of SARS-CoV-2 Viral protein [DOI] 10.1002/cbic.202200327 PMC 바로가기
Identification of SARS-CoV-2 Main Protease Inhibitors from a Library of Minor Cannabinoids by Biochemical Inhibition Assay and Surface Plasmon Resonance Characterized Binding AffinityArticle Published on 2022-09-192022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] activity acute respiratory syndrome affinity binding binding affinity biochemical biochemical assay cannabinoid chemotype coronavirus coronavirus disease COVID-19 decarboxylation Effect evaluated Evidence finding identification in silico inhibition inhibitor inhibitory effect library M pro main protease (Mpro) minor minor cannabinoids molecular docking molecular interaction Plasmon protease Protein Replication reported resonance SARS-CoV-2 SPR structure and activity relationship Support surface surface plasmon resonance the binding affinity therapeutic target [DOI] 10.3390/molecules27186127 PMC 바로가기