Discovery of naturally occurring inhibitors against SARS-CoV-2 3CL pro from Ginkgo biloba leaves via large-scale screening대규모 스크리닝을 통해 Ginkgo Biloba 잎에서 SARS-COV-2 3CL Pro에 대한 자연 발생 억제제 발견Article Published on 2021-07-012022-08-31 Journal: Fitoterapia [Category] SARS, 치료제, [키워드] 3CL pro activities Bioflavones broad spectrum Chymotrypsin-like protease Compound Coronaviruses demonstrated docking Ginkgo Ginkgo biloba Ginkgo biloba leaves Ginkgolic acids inhibit SARS-CoV-2 inhibition inhibition activity Inhibition assays inhibitor inhibitors inhibitory Inhibitory mechanism kinetic less mechanism medication offer protease proteinase SARS-CoV-2 SARS-CoV-2 3CL(pro). tested Viral viral replication [DOI] 10.1016/j.fitote.2021.104909 PMC 바로가기 [Article Type] Article
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 proteinSARS-CoV-2 NSP14 단백질에 의한 타고난 면역 반응의 번역 차단 및 회피423 Published on 2021-06-152022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, [키워드] active site active sites activities acute respiratory syndrome acute respiratory syndrome coronavirus addition Antiviral antiviral proteins antiviral response causative agent caused complex conserved coronavirus COVID-19 COVID-19 pandemic Critical demonstrated ENhance evade ExoN Exoribonuclease Health Health crisis Host host antiviral responses Host immune response host immune responses host protein human coronaviruses IFN-I IFN-I responses immune evasion immune responses Infection inhibit inhibition activity inhibitor inhibitory innate immune response Innate immunity interferon interferon-stimulated gene interferon-stimulated genes ISGs mechanism nsp14 overcome Pathogenesis pathogenesis of SARS-CoV-2 pathogenic virus pathogenic viruses Pathogens previous study Protein Proteins replicate required respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance subversion synthesis the SARS-CoV-2 translation translation inhibition translational type I interferon Viral viral pathogens virus replication viruses [DOI] 10.1073/pnas.2101161118 PMC 바로가기 [Article Type] 423
Native High-Density Lipoproteins (HDL) with Higher Paraoxonase Exerts a Potent Antiviral Effect against SARS-CoV-2 (COVID-19), While Glycated HDL Lost the Antiviral ActivityArticle Published on 2021-02-012022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] accelerated acetylated activity anti-infection antioxidant antiviral activity calculated Cell correlation COVID-19 COVID-19 infection CPE Cytopathic effect cytotoxicity Effect explain Final Glycation HDL HDL-C high-density high-density lipoproteins (HDL) higher risk Human hypertension impair in vitro inhibition activity LDL lipoprotein Low-density lipoprotein low-density lipoproteins Mortality Native paraoxonase patients with diabete phagocytosis potent pro-inflammatory progression Protein reported SARS-CoV-2 selective serum Vero E6 viability while [DOI] 10.3390/antiox10020209 PMC 바로가기 [Article Type] Article
Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against CoronavirusReview Published on 2020-12-072022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] antiviral agent Bacteria carbohydrate carriers cell membrane component coronavirus Coronaviruses COVID-19 COVID-19 pneumonia fungi inhibition activity lectin lectins Lipid liposomes micelles microorganisms nanoformulations natural protein neutralize outbreak parasites Pneumonia Vaccine virulence viruses Wuhan, China [DOI] 10.3390/biomedicines8120580 PMC 바로가기 [Article Type] Review
Pharmacophore modelling of vanillin derivatives, favipiravir, chloroquine, hydroxychloroquine, monolaurin and tetrodotoxin as M Pro inhibitors of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)Research Note Published on 2020-11-112022-10-27 Journal: BMC Research Notes [Category] COVID-19, [키워드] acceptor acute respiratory syndrome antiviral drugs approach binding site bond Chloroquine complex coronavirus Coronavirus-2 COVID-19 derivative derivatives evaluate Favipiravir feature hydrogen Hydroxychloroquine inhibition activity inhibitor inhibitors Interaction interactions monolaurin objective performed pharmacophore pharmacophore modelling Pro Remdesivir Result Ritonavir SARS-CoV-2 Tetrodotoxin Vanillin were used [DOI] 10.1186/s13104-020-05379-6 PMC 바로가기 [Article Type] Research Note
Pharmacophore modelling of vanillin derivatives, favipiravir, chloroquine, hydroxychloroquine, monolaurin and tetrodotoxin as M Pro inhibitors of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)Research Note Published on 2020-11-112022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, SARS, [키워드] acceptor acute respiratory syndrome antiviral drugs approach binding site bond Chloroquine complex coronavirus Coronavirus-2 COVID-19 derivative derivatives evaluate Favipiravir feature hydrogen Hydroxychloroquine inhibition activity inhibitor inhibitors Interaction interactions monolaurin objective performed pharmacophore pharmacophore modelling Pro Remdesivir Result Ritonavir SARS-CoV-2 Tetrodotoxin Vanillin were used [DOI] 10.1186/s13104-020-05379-6 PMC 바로가기 [Article Type] Research Note
Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2Review Published on 2020-09-012022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] absence ACE2 ACE2 receptor acute respiratory syndrome affected Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral activity bind blood pressure caused coronavirus country CoV COVID-19 Critical death drug Efficacy effort epithelial cell flavonoid functional Host host cells in vitro increase in infect inhibition activity Medicine morbidity Mortality natural Novel coronavirus outbreak over pandemic Potential potential therapeutic target previous study public health threat receptor Regulation SARS-CoV-2 the spike protein these compound virus with COVID-19 [DOI] 10.3390/molecules25173980 PMC 바로가기 [Article Type] Review
The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activityResearch Published on 2014-12-072022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Activation activity blocked chromatin immunoprecipitation complex interaction contribute coronavirus dependent on DNA binding downstream DUB EMSA engage experiment expressing Factors Host identify IFN Infection inhibit inhibited inhibiting inhibition activity innate immune innate immune response Innate immunity interferon IRF3 mechanism Mutagenesis mutant nuclear outcome Pathogenesis pathway Phosphorylation Plasmid PLPro potential mechanism protease Protein regulate regulated Result SARS Coronavirus SARS-CoV Severe acute respiratory syndrome shift shown Signaling Type I IFN type I interferon viral infection [DOI] 10.1186/s12985-014-0209-9 PMC 바로가기 [Article Type] Research