inhibitory – Page 2 – Communicable Diseases Research

Engineering recombinantly expressed lectin-based antiviral agents

Article

Published on 2022-09-232022-11-15
Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory syndrome antiviral agent binding binding affinity binding mechanism binding site carbohydrate carbohydrate-binding agent Coronavirus-2 cyanovirin-N Ebola Engineering expressed high-mannose HIV Human immunodeficiency virus infection with influenza inhibitory Interaction investigated isothermal titration calorimetry ITC lectin mechanism mutated N-linked glycan neutralization ability neutralizing antibody Nostoc oligosaccharides peptide polar interactions Protein RBD residue SARS-CoV-2 SARS-CoV-2 glycoprotein spike spike glycoprotein Spike protein SPR tested transfer variant viral membrane viral spikes virus was measured were used
[DOI] 10.3389/fcimb.2022.990875 PMC 바로가기

A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry

Article

Published on 2022-08-302022-11-15
Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] acute respiratory syndrome all-trans retinoic acid analogue antibody antiviral activity Apoptosis ATRA bind binding Cell cellular cellular entry Compound coronavirus Coronaviruses COVID-19 derivative disease Efficacy etiological agent feasibility global pandemic growth human cell line hydrophobic pocket include inhibitory Interaction Interrupting life-threatening coronavirus disease Lower respiratory tract mechanism metabolite organ systems Organoid pharmacological physiological prevention of COVID-19 RBD Receptor binding domain regulate reported retinol S trimer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Spike protein structural mechanism. the SARS-CoV-2 therapeutic trimer Vaccine vitamin A
[DOI] 10.1128/mbio.01485-22 PMC 바로가기

Neutralizing Antibody Response to Pseudotype Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Differs Between mRNA-1273 and BNT162b2 Coronavirus Disease 2019 (COVID-19) Vaccines and by History of SARS-CoV-2 Infection

유사형 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 중화 항체 반응은 mRNA-1273과 BNT162b2 코로나바이러스 질병 2019(COVID-19) 백신과 SARS-CoV-2 감염의 역사에 따라 다릅니다.

Article

Published on 2022-08-242022-09-12
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단,

[키워드] 19 2 95% confidence interval Antibody titer BNT162b2 BNT162b2 vaccine calculated coronavirus 2 CoV COVID COVID-19 Dilution dose geometric mean GMT GMTs highest history increase Infection inhibitory linear mixed-effects models mRNA mRNA COVID-19 vaccine mRNA vaccine mRNA-1273 mRNA-1273 vaccine NAb Neutralizing antibodies neutralizing antibody participant participants with SARS-CoV-2 prospective cohort pseudotype virus receiving respiratory response SARS SARS-CoV-2 SARS-COV-2 infection sera single dose Symptoms T Test tested uninfected participant uninfected participants vaccination Vaccine vaccine dose was collected
[DOI] 10.1093/cid/ciab1038 PMC 바로가기 [Article Type] Article

SARS-CoV-2 RBD-Specific Antibodies Induced Early in the Pandemic by Natural Infection and Vaccination Display Cross-Variant Binding and Inhibition

Article

Published on 2022-08-242022-11-15
Journal: Viruses [Category] SARS, 변종, 진단,

[키워드] ACE2 ACE2 binding acute respiratory syndrome angiotensin-converting enzyme 2 antibody approved Beta binding BNT162b2 ChAdOx1 nCoV-19 circulating collected coronavirus country COVID-19 cross-reactive cross-reactivity Denmark display dose Efficacy examined Gamma greater IgG Immunity induced infected with SARS-CoV-2 inhibited inhibition inhibitory less mechanisms natural natural infection omicron Oxford-AstraZeneca pandemic Pfizer-BioNTech receptor Receptor binding domain reduced regimen response SARS-CoV-2 Strains subject subjects susceptibility sustained symptomatic transmission rate vaccination Vaccine vaccine candidate variant variants of concern were used wild-type
[DOI] 10.3390/v14091861 PMC 바로가기

Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition

Research

Published on 2022-08-222022-10-05
Journal: Nature Medicine [Category] 변종, 비임상, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제,

Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

에센셜 오일 및 방향족 추출물의 anti-SARS-CoV-2 특성 평가

Article

Published on 2022-08-202022-09-11
Journal: Scientific Reports [Category] SARS, 신약개발, 치료제,

Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties

Research

Published on 2022-08-162022-10-05
Journal: Scientific Reports [Category] SARS, 신약개발, 치료제,

Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces

스파이크 단백질/ACE2 인터페이스를 조절하여 SARS-CoV-2 세포 진입의 새로운 억제제로서 비스-인돌릴 피리딘 및 트리페닐아민 선택

Article

Published on 2022-08-162022-09-11
Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종,

[키워드] 50% effective concentration ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus approaches association biochemical caused Cell cell lines cellular cellular receptor circulating circulating variant complex Compound coronavirus coronavirus disease COVID COVID-19 docking drug functional human cell lines identify in silico indicate Infection infectious agent inhibit inhibitor inhibitory inhibitory effect Interaction interface Lentiviral vector lentiviral vectors modulating molecular molecules New pandemic parameter pseudotyped pyridine receptor ACE2 S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein SARS-CoV-2 strain screened selected Selection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike susceptible the SARS-CoV-2 the Spike therapeutic purposes these compound these compounds triphenylamine variant viral entry viral infection viral replication virus wild-type
[DOI] 10.1128/aac.00083-22 PMC 바로가기 [Article Type] Article

Host and microbiome features of secondary infections in lethal covid-19

Research article

Published on 2022-08-132022-10-05
Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술,

Unveiling the “Template-Dependent” Inhibition on the Viral Transcription of SARS-CoV-2

SARS-CoV-2의 바이러스 전사에 대한 "템플릿-의존성" 억제 공개

Article

Published on 2022-08-112022-09-11
Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 치료제,