The Matrix-M™ adjuvant: A critical component of vaccines for the 21 st centuryImmunology Published on 2023-04-272024-09-04 Journal: Human vaccines & immunotherapeutics [Category] 대상포진, [키워드] Adaptive immune response COVID-19 immunogenicity innate immune response Matrix-M™ adjuvant mechanism of action Quillaja saponin Safety SARS-CoV-2 Vaccine [DOI] 10.1080/21645515.2023.2189885 PMC 바로가기 [Article Type] Immunology
Current status of hand-foot-and-mouth diseasearticle Published on 2023-02-242024-09-02 Journal: Journal of Biomedical Science [Category] 대상포진, [키워드] Epidemiological characteristic Hand-Foot-and-Mouth Disease innate immune response Sequelae Treatment [DOI] 10.1186/s12929-023-00908-4 PMC 바로가기 [Article Type] article
LGP2 Promotes Type I Interferon Production To Inhibit PRRSV Infection via Enhancing MDA5-Mediated SignalingVirus-Cell Interactions Published on 2023-01-092024-09-05 Journal: Journal of virology [Category] update2024, [키워드] innate immune response LGP2 MDA5 nsp1 NSP2 PRRSV [DOI] 10.1128/jvi.01843-22 PMC 바로가기 [Article Type] Virus-Cell Interactions
COVID-19-related headache and innate immune response – a narrative reviewReview Published on 2023-01-012023-07-09 Journal: Neurologia i neurochirurgia polska [Category] COVID19(2023년), [키워드] IFN IL-1β IL-6 innate immune response Pain SARS-CoV-2 TLR-7 TNF [DOI] 10.5603/PJNNS.a2022.0049 [Article Type] Review
Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamstersArticle Published on 2022-12-012023-07-10 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), [키워드] innate immune response interferon treatment Lung pathology SARS-CoV-2 Omicron [DOI] 10.1038/s41423-022-00923-9 PMC 바로가기
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-α수두-대상포진 바이러스 감염 후 인간 iPSC 유래 신경세포 인 비트로 모델에서 인터페론 자극 유전자의 활성화는 외부 인터페론-α에 의존한다.Article Published on 2022-11-142023-05-31 Journal: Viruses [Category] 대상포진, 두창, 수두, 홍역, [키워드] antiviral response axonal infection innate immune response interferon-stimulated genes Interferon-α IPSC neuronal models neurons Varicella-Zoster Virus [DOI] 10.3390/v14112517 PMC 바로가기
Targeting SARS-CoV-2 papain-like protease in the postvaccine eraArticle Published on 2022-11-012022-11-15 Journal: Trends in pharmacological sciences [Category] SARS, 치료제, [키워드] approval artificial intelligence Compound computer-aided drug design COVID-19 Critical direct-acting antiviral drug drugs expected global healthcare Host innate immune response methodology Papain-like protease PLPro Rapid responses SARS-CoV-2 SARS-CoV-2 protein Small molecules small molecules. targeting therapeutic target Vaccine viral replication waning immunity while [DOI] 10.1016/j.tips.2022.08.008 PMC 바로가기
Type I interferon receptor signalling deficiency results in dysregulated innate immune responses to SARS-CoV-2 in miceArticle Published on 2022-11-012023-07-10 Journal: European Journal of Immunology [Category] COVID19(2023년), [키워드] in vivo innate immune response myeloid cells SARS-CoV-2 Type I IFN [DOI] 10.1002/eji.202249913 PMC 바로가기
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsArticle Published on 2022-10-302022-11-16 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Analysis analyzed biochemically bioinformatics catalytic caused changed characterization characterized cleavage Combination conserved coronavirus Coronaviruses Course COVID-19 pandemic domain drug design effort endoribonuclease endoribonuclease. EndoU evade Evolution facilitate Genome help Host immune response in vivo inactive increase in innate immune response middle monomeric Mutation N-terminal nonstructural proteins novel coronavirus SARS-CoV-2 Nsp15 oligomerization pandemic Patient prevalent Protein residue RNA SARS-CoV-2 SARS-CoV-2 sequence Sequencing Transcription triggering understanding variant viral genome Viral protein viral replication virus wild type [DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기