Performance evaluation of an automatic chemiluminescence immune platform for SARS-CoV-2 neutralizing antibody after vaccination in real worldSARS-COV-2를위한 자동 화학 발광 면역 플랫폼의 성능 평가 현실에서 예방 접종 후 항체Research Published on 2022-02-152022-09-01 Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, [키워드] Adolescent BBIBP-CorV changes in Characteristics chemiluminescence China CLIA Cohort CoronaVac doses evaluated exceeded Follow-up followed by Hemolysis high correlation icterus immune immunity after vaccination immunoassays inactive injection inoculation investigated less linearity lipemia measure Neutralizing activity Neutralizing antibodies neutralizing antibody objective occurred performance Physical examination Plaque reduction neutralization test platform predominant PRNT Real world recipient recruited repeatability Result robust SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccine schedule Sensitivity and specificity Serological assay serological assays seropositive Shenzhen significantly lower Sinovac strength Trial vaccination Vaccination Status Vaccinations Vaccine Variation volunteers [DOI] 10.1186/s12879-022-07141-8 PMC 바로가기 [Article Type] Research
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients통합된 조직병리학, 지질학 및 대사체 프로필은 밍크가 심각한 COVID-19 환자의 병원성을 모방하는 유용한 동물 모델임을 보여줍니다Article Published on 2022-01-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, 치료법, 치료제, [키워드] Absorption accompanied activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus alteration alveolar damage amino acids Analysis animal model Anti-inflammatory characterized cholesterol contributed coronavirus correlated COVID-19 patients demonstrated Diffuse alveolar damage digestion digestive distribution downregulated dysregulation effective Effects Endocrine fatal COVID-19 feature fetal hepatic dysfunction highlight histological histopathological Human immune dysregulation immune systems immunomodulating Infection Infectious diseases Inflammatory response inoculation Kynurenine Kynurenine pathway lesion Lipid lipids Macrophage macrophage activation macrophages melatonin metabolic pathways metabolite metabolites metabolomic observation pathogenicity pathophysiological feature Patient post inoculation potential biomarkers profile Proteins reported Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient significantly Steroids transmitted Treatment strategies Vaccine Viral Viral protein vitamins was related widespread [DOI] 10.1038/s41392-022-00891-6 PMC 바로가기 [Article Type] Article
A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-22가 나노입자 백신은 SARS-CoV-2 변종에 대한 강력한 교차 보호를 나타냅니다.Article Published on 2022-01-182022-09-11 Journal: Cell Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin B.1.351 B.1.351 variants bivalent nanoparticle vaccine. boost coronavirus cross-neutralizing antibodies cross-neutralizing antibody cross-protection D614G dose elicit exhibit human Angiotensin-converting enzyme immune evasion Infection infection with SARS-CoV-2 initial inoculation mice Neutralizing antibodies neutralizing antibody Prevent RBDs Receptor binding domain receptor binding domains rhesus macaques robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single dose Strains transgene Vaccine variants variants of SARS-CoV-2 [DOI] 10.1016/j.celrep.2021.110256 PMC 바로가기 [Article Type] Article
Prevalence of SARS-CoV-2 Variants of Concern and Variants of Interest in COVID-19 Breakthrough Infections in a Hospital in Monterrey, MexicoSARS-COV-2 우려 변동의 유병률 및 멕시코 몬테레이에있는 병원에서 COVID-19 획기적인 감염에 대한 관심의 변형Observational Study Published on 2022-01-142022-09-10 Journal: Viruses [Category] SARS, 변종, 임상, 치료기술, [키워드] Administered ambulatory patient ambulatory patients AstraZeneca B.1.617.2 B.1.621 Breakthrough infection breakthrough infections CanSino case-control study Complete concern control group COVID-19 COVID-19 vaccines defined Delta Efficacy first dose hospital Hospitalization Hospitalized hospitalized patient hospitalized patients immunization increased risk inoculation interest Latin America Local Mexico mild COVID-19 symptom mild COVID-19 symptoms Mu occurred Patient patients Pfizer/BioNTech Prevalence public health SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second dose Sinovac Surveillance therapy vaccination Vaccine vaccine administration vaccine breakthrough infection vaccine breakthrough infections Vaccines variant of concern VoC VOCs VOIs was performed whole-genome sequencing [DOI] 10.3390/v14010154 PMC 바로가기 [Article Type] Observational Study
Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum AdjuvantsImmunology Published on 2022-01-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] acute respiratory syndrome adjuvant adjuvants Administered alum alum adjuvant antigen-specific antibody approach cartilage coronavirus coronavirus disease COVID-19 COVID-19 pandemic effective Effectiveness efficient Euglena evaluated examined expression expression vector highlight host cells induce induction Infection inoculation mice motif mouse serum neutralizing antibody optimization paramylon produced Protein purified S protein SARS-CoV-2 secreted serum Silkworm-baculovirus expression vector system spike spike (S) protein Spread subunit the S protein therapeutic agents trimeric Vaccine Vaccine development was used [DOI] 10.3389/fimmu.2021.803647 PMC 바로가기 [Article Type] Immunology
The incidence of COVID-19 infection following emergency use authorization of BBIBP-CORV inactivated vaccine in frontline workers in the United Arab Emirates응급 사용 후 Covid-19 감염의 발생률은 아랍 에미리트의 최전선 근로자에서 BBIBP-CORV 불활성 백신의 승인Article Published on 2022-01-112022-09-10 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, [키워드] 95% CI BBIBP-CorV clinical trial conducted COVID-19 COVID-19 infection COVID-19 infections dose Emergency use authorization Epidemiology EUA first dose inactivated Inactivated vaccine incidence of COVID-19 incidence rate individual Infection inoculation Medical research Outcomes research PCR positive phase Phase III clinical trials prospective cohort study reported risk SARS CoV second dose Serious Adverse Event Serious Adverse Events seroconversion rate severe disease suffered symptomatic symptomatic infection the vaccine United Arab Emirate vaccinated individual vaccinated individuals vaccination Vaccine [DOI] 10.1038/s41598-021-04244-1 PMC 바로가기 [Article Type] Article
Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster골든 시리아 햄스터에서 D614- 또는 G614-SARS-CoV-2 분리주를 통한 재감염 방지Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] affected animal model animals COVID-19 elicit golden Syrian hamster hamster humans Immunity immunological mechanism incidence Infection inoculation isolate Lower respiratory tract Lung disease Mild much lower nasal tissue Neutralizing antibodies pathological aspects patients PROTECT protection public health question raise Re-infection Reinfection respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates Seven sterilizing immunity subsequent susceptible These data titre upper and lower respiratory tracts variant Viral viral replication Viral variants [DOI] 10.1080/22221751.2021.1913974 PMC 바로가기 [Article Type] Article
COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory AnalysisCOVID-19 백신 관련 혈전증: 체계적인 검토 및 탐색적 분석Immunology Published on 2021-11-292022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 Adenovirus adenovirus-based Admission adverse effect adverse event adverse events affected age antibodies antibody appearance article assumed AstraZeneca Atypical binding caused complex Complication coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 vaccination COVID-19 vaccinations COVID-19 vaccine Critical database Descriptive analysis DNA endothelial Endothelial cell endothelial cells events except for expressing Features female Genetic headache Health Organization heparin heparin-induced thrombocytopenia heterogeneity High-risk patients hypothese identify individual Inflammatory inoculation limit male material mechanism Moderna mRNA mRNA-based negative charge New normal range outcome pandemic pathophysiological mechanism pathophysiological mechanisms Patient performed petechiae PF4 PF4 antibodies Pfizer physiopathological mechanism Platelet Platelet count positive predisposition Prevalence prevalent Protein purpura recent remained Result review secondary to selected Symptom the patient thrombocytopenia thrombosis thrombotic Thrombotic thrombocytopenia vaccination Vaccine vaccine adverse effects vaccine complications vaccine-related thrombosis Vaccines variant venous venous sinus Viral viral DNA Viral vector viral vectors World Health Organization [DOI] 10.3389/fimmu.2021.729251 PMC 바로가기 [Article Type] Immunology
Ameliorated immunity elicited by intradermal inoculation in individuals vaccinated with inactivated SARS-CoV-2 vaccine비활성화된 SARS-CoV-2 백신 접종을 받은 개인의 피내 접종으로 유도된 개선된 면역Article Published on 2021-11-262022-09-11 Journal: Vaccine [Category] MERS, SARS, 진단, 치료기술, [키워드] activated anti-S antibody antibody Antigen Antigen inoculation clinical trials clinically effective elicited eliminated ELISA IgGs immune response Immunity immunization immunized inactivated individual inflammatory reactions inoculation Intradermal Intradermal immunization neutralizing antibody participant Participants persistence problem protective effect redness SARS-CoV-2 SARS-CoV-2 vaccine short duration swelling the antibody [DOI] 10.1016/j.vaccine.2021.10.043 PMC 바로가기 [Article Type] Article
SARS-CoV-2 could be spread through hospital medication dispensed to patients: A prospective observational studySARS-CoV-2는 환자에게 조제된 병원 약물을 통해 전파될 수 있음: 전향적 관찰 연구Observational Study Published on 2021-11-122022-09-11 Journal: Medicine [Category] MERS, SARS, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 analyzed Chain Reaction confirmation Contamination control group Coronavirus-2 different material different materials drug drugs effective evaluate hospital Hospital wards ICU in vitro inoculated inoculation intensive care intensive care unit Laboratory lack medication pandemic persistence plastic bag polymerase chain polymerase chain reaction potential transmission Prevent prospective observational study real time respiratory reverse transcription reverse transcription polymerase chain reaction Sample SARS-CoV-2 SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spread stability sterile swab virus was performed [DOI] 10.1097/MD.0000000000027592 PMC 바로가기 [Article Type] Observational Study