Putative Host-Derived Insertions in the Genomes of Circulating SARS-CoV-2 VariantsArticle Published on 2022-06-282023-07-09 Journal: mSystems [Category] COVID19(2023년), [키워드] host-viral chimeric reads insertion ribosomal RNA. SARS-CoV-2 [DOI] 10.1128/msystems.00179-22 PMC 바로가기
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655YIns215KLRS 및 H655Y의 비 RBD 돌연변이에 의한 SARS-CoV-2의 N501Y 부여 마우스 감염성의 장거리 향상Article Published on 2022-06-052022-09-11 Journal: Biology Direct [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 Alpha Beta changes in cooperation Cross-species transmission disrupt ENhance facilitate flexible Gamma H655Y high infectiousness hosts Impact impacts increase Ins215KLRS insertion Interaction intramolecular interaction less Local mice mouse Mouse infection mouse-adapted strain mutant Mutation N-terminal domain N501Y N501Y mutation NTD omicron Omicron variants peptide Protein RBD Receptor binding Receptor-binding domain resulting rodents SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2. spike Spike protein suppressed targets the receptor-binding domain variant virus infectivity wild type [DOI] 10.1186/s13062-022-00325-x PMC 바로가기 [Article Type] Article
HLA-G 14-bp insertion/deletion polymorphism and risk of coronavirus disease 2019 (COVID-19) among Iraqi patients이라크 환자의 HLA-G 14bp 삽입/삭제 다형성 및 코로나바이러스 질병 2019(COVID-19)의 위험Article Published on 2022-06-012022-09-11 Journal: Human immunology [Category] 변종, [키워드] 14-bp insertion/deletion polymorphism 3′UTR 95% confidence interval allele Antigen case-control study conducted Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical disease Del disease severity Frequency Gender Genotype genotypes higher risk HLA-G Human human leukocyte antigen insertion insertion/deletion leukocyte median no significant difference no significant differences Odds ratio Patient patients with COVID-19 patients with moderate polymorphism Probability Result risk risk of COVID-19 SARS-CoV-2 SARS-CoV-2. serum significantly significantly higher stratified suggested susceptibility up-regulated with COVID-19 [DOI] 10.1016/j.humimm.2022.03.005 PMC 바로가기 [Article Type] Article
The Biological Functions and Clinical Significance of SARS-CoV-2 Variants of CorcernReview Published on 2022-05-202022-10-06 Journal: Front Med (Lausanne) [Category] 진단, [키워드] ACE2 acute respiratory syndrome Affect Alpha variant Angiotensin-converting enzyme antigenic B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Biological blunt Brazil Characteristics clinical Combination convalescent individuals coronavirus country COVID-19 COVID-19 vaccines Deleterious Deletion Delta delta variant E484K E484K mutation Efficacy ENhance evade FIVE function Gamma Genetic immune evasion India Infection influence immune response insertion K417 Mutation mutations N501Y Neutral Neutralizing antibodies neutralizing antibody omicron optimism other variant P.1 pathogenicity phenotype promote raise RBD Receptor binding domain Region Reinfection risk SARS-CoV-2 SARS-CoV-2 variant sensitivity severe disease Significance South Africa Spike protein Spread spread to Strains the Alpha variant the Beta variant the Delta variant the Gamma variant the Omicron variant the RBD the SARS-CoV-2 the SARS-CoV-2 genome the spike protein the United State The United States Transmissibility triggered United Kingdom vaccination Vaccine-induced immunity Vaccines variant Variant of concern. variants of concern viral cell viral replication Virological virus VoC VOCs [DOI] 10.3389/fmed.2022.849217 PMC 바로가기 [Article Type] Review
The puzzling mutational landscape of the SARS-2-variant OmicronSARS-2 변종 오미크론의 수수께끼 같은 돌연변이 환경Article Published on 2022-05-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 receptor affected antibody antibody susceptibility association cleavage site Complete coronavirus decrease deletions delta variant dissemination electrostatic Epitopes Evolution explain geometric human population immunological Infection initial initial assessment insertion less molecular mechanism molecular mechanisms mutations N-terminal domain neutralizing epitope neutralizing epitopes NTD omicron Omicron variant parameter Pathogenesis pathogenic phenotype predicted RBD Receptor-binding domain SARS Coronavirus SARS-CoV-2 variant Spike protein surface potential the receptor-binding domain Transmission Vaccine variant Virological virulence virus virus classification virus classification. [DOI] 10.1002/jmv.27577 PMC 바로가기 [Article Type] Article
Conserved Pattern and Potential Role of Recurrent Deletions in SARS-CoV-2 EvolutionSARS-CoV-2 진화에서 보존된 패턴 및 반복 삭제의 잠재적 역할Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] adaptive adaptive evolution addition association binding site Combination coronavirus COVID-19 deleted Deletion deletions described disease distribution Epidemic Evidence Evolution functions genome structure greater Host human host indicated insertion insertions integration means Mutation N-terminal domain Neutralizing antibodies NSP6 nucleotide nucleotide change occurred pattern Potential Prevention and control Previous studies proliferation Protein RDRs Receptor binding domain Recurrent recurrent deletion Region regions reported role SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-related coronavirus SARS-related coronaviruses single nucleotide Spike protein Strains Structural variation structural variation. structural variations the spike protein the WHO unique Vaccine development variant variants variants of concern variants of interest Variation Viral viral genome virus Virus evolution viruses VoC whole genome worldwide pandemic Δ144 Δ69-70 [DOI] 10.1128/spectrum.02191-21 PMC 바로가기 [Article Type] Article
The stalk domain of SARS-CoV-2 NSP13 is essential for its helicase activitySARS-CoV-2 NSP13의 줄기 도메인은 헬리카제 활성에 필수적입니다Article Published on 2022-04-232022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] affected ATPase binding ability caused connection COVID-19 demonstrated domain domains dsRNA effort enzymatic activity enzyme flexible linker Health Helicase highlight insertion involved lack linker nsp13 provide remained Rigid connection RNA SARS-CoV-2 SARS-CoV-2 nsp13 SARS-CoV-2 replication stalk Stalk. thermal stability Transcription was impaired [DOI] 10.1016/j.bbrc.2022.02.068 PMC 바로가기 [Article Type] Article
Nasal pressure swings as the measure of inspiratory effort in spontaneously breathing patients with de novo acute respiratory failureArticle Published on 2022-03-242022-10-05 Journal: Critical Care [Category] 임상, [키워드] Acute respiratory failure Admission Alter ARF cannula changes in clinical Clinical outcome Clinical practice cohort of patient consecutive patient correlated correlation COVID-19 de novo endotracheal Endotracheal intubation enrolled Escalation Esophageal pressure swings feature insertion Inspiratory effort intensive care unit Italy limit Lung injury magnitude measure Mechanical Modena nasal Nasal pressure swings non-invasive mechanical ventilation Non-invasive respiratory support non-invasive ventilation Patient Primary outcome R 2 remained required respiratory Respiratory failure Respiratory mechanics respiratory monitoring respiratory rate Self-Inflicted Lung Injury Self-inflicted lung injury. significantly splitting study population swing translate university were recorded worsening [DOI] 10.1186/s13054-022-03938-w PMC 바로가기 [Article Type] Article
Erythro-VLPs: Anchoring SARS-CoV-2 spike proteins in erythrocyte liposomesErythro-VLPS : 적혈구 리포좀에서 SARS-COV-2 스파이크 단백질을 고정시킨다Research Article Published on 2022-03-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus 2 Administered anchoring angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 assays average binding BLI Blood blood cell Cell coronavirus coronavirus disease COVID-19 cytoplasmic membrane defined dose-dependent Dynamics ELISA enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays facilitate fluorescent functional insertion intravenously Liposome membranes molecular dynamics novel open outer membrane pandemic Particles platform Protein protocol red blood cell respiratory S-protein SARS-CoV-2 spike SARS-CoV-2 spike protein scattering Seroconversion severe acute respiratory syndrome Coronavirus surfactant the SARS-CoV-2 therapeutic strategy Therapeutics Trial variants virus virus viruses was used [DOI] 10.1371/journal.pone.0263671 PMC 바로가기 [Article Type] Research Article
Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: A rather controversial hypothesis. A case-control study안지오텐신전환효소 삽입/제거 다형성, ACE 활성, 그리고 코로나19: 다소 논란의 여지가 있는 가설. 사례 대조 연구Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, 유전자 메커니즘, [키워드] ACE ACE activity ACE inhibitor ACE inhibitors ACE polymorphism allele alleles Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme. Angiotensin receptor blockers Angiotensin-converting enzyme arbitrary units carrier case-control study characterized complex conducted Control controls COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient disease severity enzyme epidemiological data expressed First wave Generalized linear model Genotype genotypes healthy individual healthy individuals Hypothesis I/D genotype increased risk individuals insertion insertion/deletion limit mechanism Patient Poisson regression polymorphism Prevalence recruited reduction Renin renin-angiotensin system retrospective risk factor risk ratio risk ratios RRs SARS-CoV-2 severe disease severity shown synergy therapy was used [DOI] 10.1002/jmv.27417 PMC 바로가기 [Article Type] Article