Structural and Dynamic Insights into SARS-CoV-2 Spike-Protein-Montmorillonite InteractionsSARS-CoV-2 스파이크-단백질-몬모릴로나이트 상호작용에 대한 구조적 및 동적 통찰력Article Published on 2022-08-022022-09-11 Journal: Langmuir : the ACS journal of surfaces and colloid [Category] COVID19(2023년), SARS, 변종, [키워드] Cell cell entry Critical develop drug drug therapy dynamic effective electrostatic explicit glycan glycans help hydrophobic hydrophobic interaction hydrophobic interactions immune response insight Interaction interactions Ion mechanism Modification molecular dynamics Molecular dynamics simulation Montmorillonite nanoparticle pandemic performed probe Protein provide residue residues S protein SARS-CoV-2 therapeutic therapy Vaccine Vaccine development Vaccines variant virus world population [DOI] 10.1021/acs.langmuir.2c00837 PMC 바로가기 [Article Type] Article
Insight into molecular characteristics of SARS-CoV-2 spike protein following D614G point mutation, a molecular dynamics studyD614G 점 돌연변이에 따른 SARS-CoV-2 스파이크 단백질의 분자 특성에 대한 통찰력, 분자 역학 연구Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] addition Amino acid amino acid sequence asymmetric bioinformatics catastrophic changes in Characteristics D614G D614G mutation Effect effective high mortality rate insight molecular molecular dynamics molecular dynamics. mutant Mutation negative charge Point mutation polar positive Positive Charge Protein public health Receptor binding residue risk factor SARS-CoV-2 SARS-CoV-2 spike protein secondary structure sequence spike stability Substitution tertiary structure the SARS-CoV-2 Treatment virus [DOI] 10.1080/07391102.2021.1872418 PMC 바로가기 [Article Type] Article
Insights into the structural peculiarities of the N-terminal and receptor binding domains of the spike protein from the SARS-CoV-2 Omicron variantSARS-CoV-2 Omicron 변이체의 스파이크 단백질 N-말단 및 수용체 결합 도메인의 구조적 특성에 대한 통찰력Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility ACE2 addition Analysis antibody B.1.1.529 BA.1) binding binding domain binding efficiency changes in computational analysis COVID-19 COVID-19 vaccines Effect Epitopes evaluated free energy glycan glycans higher infectivity insight Interaction mAb molecular dynamics molecular dynamics simulations Mutation N-terminal N-terminal domain N-terminal domain (NTD) Neutralizing NTD NTDs omicron Omicron (B.1.1.529 Omicron variant performed Protein provide raised RBD RBD domain RBDs Receptor binding domain receptor binding domain (RBD) reduce reducing residue SARS-CoV-2 SARS-CoV-2. specific antibodies Spike protein stability the RBD the SARS-CoV-2 the spike protein variant variant of SARS-CoV-2 Wuhan [DOI] 10.1016/j.compbiomed.2022.105735 PMC 바로가기 [Article Type] Article
Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic AnalysesSARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력Article Published on 2022-08-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNA. miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability [DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article
Sequence Similarity Network Analysis Provides Insight into the Temporal and Geographical Distribution of Mutations in SARS-CoV-2 Spike ProteinSARS-CoV-2 스파이크 단백질 돌연변이의 시간적 및 지리적 분포에 대한 통찰력을 제공하는 서열 유사성 네트워크 분석Article Published on 2022-07-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Adaptability approach concerning coronavirus defined Evolution geographical distribution identify in viral infect insight maps Multiple sequence alignment mutable mutant Mutation mutations network offer produced profile Protein provided Region reported S protein SARS-CoV-2 sequence Sequence alignment sequence similarity sequence similarity network sequences Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus spike Spike protein spike protein. Spread stability Statistics Temporal the S protein Transmission variant variants virus viruses [DOI] 10.3390/v14081672 PMC 바로가기 [Article Type] Article
Chapter 12: Insight into coronaviruses and natural products-based approach for COVID-19 treatmentBook chapter Published on 2022-07-192022-10-05 Journal: Molecules [Category] 신약개발, 치료법, [키워드] Analysis Anticoronaviral natural products approach caused Contagion coronavirus coronavirus Coronaviruses COVID-19 Defense disease drug effective humans include insight metabolite microbe molecular docking natural nontoxic pandemic of COVID-19 Pathogens performed plant Safe SARS-CoV-2 Secondary Metabolite shown Side effect specificity therapeutic targets Treatment [DOI] 10.1016/B978-0-323-91099-6.00005-0 [Article Type] Book chapter
Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of NirmatrelvirNirmatrelvir의 잠재적인 SARS-CoV-2 회피에 대한 진화적 및 구조적 통찰력Review Published on 2022-07-142022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis analyzed antibody approval arises broad-spectrum antiviral broad-spectrum antivirals combination therapy COVID-19 pandemic drug-resistant indicate inhibitor insight M pro Mutation Nirmatrelvir Paxlovid Potential Pro protease residue residues Ritonavir SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly U.S. FDA Vaccine Viral resistance viral variant [DOI] 10.1021/acs.jmedchem.2c00404 PMC 바로가기 [Article Type] Review
Seropositivity and risk factors for SARS-CoV-2 infection in a South Asian community in Ontario: a cross-sectional analysis of a prospective cohort study온타리오주의 남아시아 지역 사회에서 SARS-CoV-2 감염에 대한 혈청 양성 및 위험 인자: 전향적 코호트 연구의 횡단면 분석Article Published on 2022-07-052022-09-12 Journal: CMAJ open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% confidence interval age age and sex antibody Baseline assessment Care Characteristics collected Community conducted COVID-19 COVID-19 pandemic cross-sectional analysis demographic demographic characteristics disease Dried blood spots employment enrolled Essential workers estimate Evidence Factor geographic location Greater Toronto Area GTA Health health information help individual information insight media pandemic participant Population prospective cohort study public health questionnaire reported risk risk factor Risk perception SARS-COV-2 infection Seropositivity South Asian was determined [DOI] 10.9778/cmajo.20220031 PMC 바로가기 [Article Type] Article
Discontinuing vs continuing ACEIs and ARBs in hospitalized patients with COVID-19 according to disease severity: Insights from the BRACE CORONA trialRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: American heart journal [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] 95% CI ACEi ACEIs angiotensin-converting enzyme inhibitor ARB ARBs baseline blocker Blood oxygen saturation clinical Clinical outcome COVID-19 disease severity days alive diagnosis of COVID-19 Discontinuing disease disease severity had more hospital hospitalized patient insight Lung imaging Mild Moderate COVID-19 no significant difference Patient patients with COVID-19 patients with moderate Primary outcome Randomized receptor the mean Trial with COVID-19 with mild disease [DOI] 10.1016/j.ahj.2022.04.001 PMC 바로가기 [Article Type] Randomized Controlled Trial
Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and TherapeuticsCOVID-19의 기계론적 모델: 질병 진행, 백신 및 치료제에 대한 통찰력Review Published on 2022-07-012022-09-11 Journal: International journal of antimicrobial agents [Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] adaptive antiviral therapeutics antiviral therapy COVID-19 COVID-19 pandemic COVID-19 vaccines Critical develop Effectiveness global effort health system health systems Immunity Immunomodulatory agents impacted IMPROVE Infection innate and adaptive immunity insight mechanism Model outcome pandemic provided Quantitative quantitative systems pharmacology SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variants Significant Therapeutics Transmission Vaccine Vaccines viral dynamics Viral dynamics models. [DOI] 10.1016/j.ijantimicag.2022.106606 PMC 바로가기 [Article Type] Review