Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related StrokeCOVID-19 관련 뇌졸중의 잠재적 생물학적 과정 및 주요 유전자를 식별하기 위한 가중 유전자 공동 발현 네트워크 분석Article Published on 2022-05-092022-09-11 Journal: Oxidative Medicine and Cellular Longevity [Category] 유전자 메커니즘, [키워드] Analysis Biological biological processe Cell coronavirus disease COVID-19 Critical Cytoscape Cytoscape software cytosolic database dataset datasets elevated enrichment analysis Extracellular matrix FIVE Functional enrichment analysis gene co-expression network Gene Expression Omnibus Gene ontology Genes GEO hub genes identify indicated integrin integrin signaling Interaction Intervention involved ITGA2B ITGB3 KEGG Kyoto Lineage network pathway Pathways PI3K PI3K-Akt signaling Platelet platelet activation Potential receptor Research screened stroke target was used [DOI] 10.1155/2022/4526022 PMC 바로가기 [Article Type] Article
Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 InfectionSARS-CoV-2 감염 시 인테그린과 캐드헤린 간의 분자 상호작용으로 혈관 장벽 무결성 상실Article Published on 2022-04-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] abnormal coagulation barrier cadherin candidate cilengitide complex Complication contribute COVID-19 Cytokine storms dysregulation Effects elicit endothelial endothelial cells Endothelial dysfunction Endotheliitis event events expressed Extracellular homeostasis Hypoxemia inhibitor integrin integrin αVβ3 Integrins integrity internalization intracellular signaling life-threatening Loss mechanism motif multiple organ failure Pathways peptide phenotype phlogistic prevented Protein receptor redistribution RGD motif SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Spike protein Support the spike protein thrombotic Thrombotic complications Trigger Vascular vascular dysfunction vascular leakage [DOI] 10.3390/v14050891 PMC 바로가기 [Article Type] Article
D-dimer and CoV-2 spike-immune complexes contribute to the production of PGE2 and proinflammatory cytokines in monocytesD-이량체 및 CoV-2 스파이크-면역 복합체는 단핵구에서 PGE2 및 전염증성 사이토카인 생성에 기여합니다Article Published on 2022-04-062022-09-12 Journal: PLoS Pathogens [Category] 진단, [키워드] accelerate activated antibody binding antibody Calcium signaling chimeric Coagulopathy coated with Combination complexes contribute convalescent plasma correlated COVID-19 cytokine D-dimer dose healthy healthy donors hospitalized COVID-19 patient hospitalized COVID-19 patients human monocyte IL-6 IL-8 immune complex increase in infiltrating monocyte Inflammatory cytokine Inflammatory cytokines inflammatory status inhibitor integrin kinase lung Lung pathology MAPK monoclonal antibody monocyte much lower neutralizing antibody titers overreactive inflammatory response pathway Patient PGE2 plasma produced Proinflammatory cytokine prostaglandin E2 pseudovirus recombinant S protein regions responses S protein SARS CoV-2 significantly Treatment viral particle [DOI] 10.1371/journal.ppat.1010468 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an α v β 3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing AntibodiesSARS-CoV-2는 백신 유도 중화 항체가 있는 경우에도 α v β 3 인테그린 매개 세포내이입을 통해 인간 ACE2 음성 내피 세포를 감염시킵니다Article Published on 2022-03-292022-09-11 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] absence ACE2 acute respiratory syndrome Angiogenesis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-spike antibodies antibody BNT162b2 BNT162b2 vaccine Cell clathrin conserved endocytosis Endothelial cell endothelial cell dysfunction endothelial cells enzyme Evidence expression functional gateway highlight Human human lung impair Infection inhibit SARS-CoV-2 integrin integrin-mediated Integrins Interaction Intervention Lineage maintain monoclonal antibody motif neutralize phenotype Presence Prevent productive viral replication promote Protein RBD Receptor binding domain respiratory responsible RGD motif SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants sequence Spike protein the SARS-CoV-2 the Spike the vaccine vaccination Viral viral envelope virus viruses αvβ3 integrin αvβ3 integrin. [DOI] 10.3390/v14040705 PMC 바로가기 [Article Type] Article
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab인플릭시맙과 베돌리주맙으로 치료받은 염증성 장질환 환자에서 SARS-CoV-2 백신 2회 투여 후 항체 붕괴, T 세포 면역 및 돌발성 감염Article Published on 2022-03-162022-09-11 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] anti-S anti-TNF antibody antibody concentration BNT162b2 Breakthrough infection breakthrough infections ChAdOx1 ChAdOx1 nCoV-19 Concentration dose drug geometric mean half-live immune responses Immunity impair induce Inflammatory bowel disease infliximab Influenza influenza vaccination integrin nCoV Necrosis of BNT162b2 p value Patient patients patients treated pneumococcal predicted protective immunity RBD required respiratory respiratory infection risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine sustained T cell T cell response treated treatment groups tumour necrosis factor U/mL vaccination vaccination schedule vaccine doses vaccine-induced immune response vedolizumab [DOI] 10.1038/s41467-022-28517-z PMC 바로가기 [Article Type] Article
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signalingSARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다Article Published on 2022-03-012022-09-11 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1 [DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article
Response to Vaccines in Patients with Immune-Mediated Inflammatory Diseases: A Narrative ReviewReview Published on 2022-02-152022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activating acute respiratory syndrome Affect antibody appear attenuate B-cell biologic Biologic therapy coronavirus CTLA-4 described dose Efficacy evaluated fusion protein healthy individuals IL-17 IL-6 immune response immune system Immune-mediated inflammatory disease Immune-mediated inflammatory diseases immunosuppressants immunosuppressive immunosuppressive drugs impair increased risk Infection Inflammatory bowel disease inhibitor inhibitors integrin Interleukins knowledge limit Live attenuated vaccine narrative Necrosis pathogenic Patient patients patients receiving treatment patients treated protective immune response protective response recommendation reduced replicate response responses review rheumatoid arthritis risk of infection Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine severe disease Therapies therapy TNF treat Treatment vaccination Vaccine vaccine response Vaccines [DOI] 10.3390/vaccines10020297 PMC 바로가기 [Article Type] Review
Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein합성 비리온은 SARS-CoV-2 스파이크 당단백질의 지방산 결합 적응 면역원성을 나타냅니다.Article Published on 2022-02-142022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adaptive binding binding pocket Bioinspired materials Cell conserved convalescent COVID-19 COVID-19 progression Dexamethasone Donor fatty Fatty acid fatty acids FDA-approved drug FFAs free fatty acid function global public health glycoprotein heterogenous Host immune response immunogenicity Immunoglobulin immunoglobulins Inflammation Inflammatory integrin Live virus mechanism mimicking modulate molecular motif Mutant SARS-CoV-2 neutralization activity Neutralizing open Pathogenesis preparation pro-inflammatory proinflammatory protocol RBD Receptor binding Receptor binding domain Regulation Regulatory responsible reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein synthetic the SARS-CoV-2 Variability Viral virion vitamin K wild-type [DOI] 10.1038/s41467-022-28446-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular DynamicsMolecular Biosciences Published on 2022-02-142022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] accelerated association bind binding site Cluster conformational COVID-19 docking Dynamics Extracellular matrix free energy landscape hindrance host receptor Hypothesis integrin Integrins Interaction microenvironment molecular molecular dynamcis motif normal mode analysis Protein RBD residue SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 virus sequence spike the RBD Validity viruses [DOI] 10.3389/fmolb.2022.834857 PMC 바로가기 [Article Type] Molecular Biosciences
Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2Research Article Published on 2022-02-102023-06-16 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), MERS, SARS, [키워드] ACE2, angiotensin-converting enzyme 2 COVID-19 COVID-19, Coronavirus disease 2019 Cy5-RBD, cyanine5-labeled RBD hACE2, human ACE2 HBSS, Hanks' banlanced salt solution integrin R403GD, arginine–glycine–aspartic acid RBD, receptor binding domain SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SPR, surface plasmon resonance virus infection [DOI] 10.1016/j.jbc.2022.101710 PMC 바로가기 [Article Type] Research Article