Intensive

[키워드] ACE2angiotensin converting enzyme 2 acute lung injury acute respiratory distress syndrome adverse outcome ALIacute lung injury alveolar type 2 cells angiotensin converting enzyme 2 ARDSacute respiratory distress syndrome AstraZeneca AT2salveolar type 2 cells ataxia telangiectasia and Rad3-related ATRataxia telangiectasia and Rad3-related BDNFbrain derived neurotrophic factor brain derived neurotrophic factor BRDbromodomain protein bromodomain protein C-reactive protein CCNG1Cyclin G1 CD147cluster of differentiation 147 Cell Clinical finding cluster of differentiation 147 confirmed case Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients COVID-19coronavirus disease 2019 CRPC-reactive protein Cyclin G1 Cytokine storm DRP1dynamin-related protein 1 dynamin-related protein 1 ECMOextracorporeal membrane oxygenation effective EGFepidermal growth factor Emergency use authorization epidermal growth factor EUAemergency use authorization EVsextracellular vesicles example exhibited Extracellular vesicles extracorporeal membrane oxygenation FGFfibroblast growth factor fibroblast growth factor galanin and gmap prepropeptide GALgalanin and gmap prepropeptide GM-CSFgranulocyte macrophage-colony stimulating factor granulocyte macrophage-colony stimulating factor HBVHepatitis B virus Heme oxygenase-1 Hepatitis B virus hepatocyte growth factor hESCshuman embryonic stem cells HGFhepatocyte growth factor hiPSCshuman induced PSCs HIVhuman immunodeficiency virus HO-1heme oxygenase-1 hPSC-CMshPSC-derived cardiomyocytes hPSC-derived cardiomyocytes hPSCshuman pluripotent stem cells human embryonic stem cells Human immunodeficiency virus human induced PSCs human pluripotent stem cells Hyperinflammatory syndrome IFN-βinterferon-β IFN-γinterferon-γ IFN-λinterferon-λ IGF1Rinsulin like growth factor 1 receptor Infection insulin like growth factor 1 receptor Intensive Interferon-β interferon-γ interferon-λ keratinocyte growth factor-2 KGF2keratinocyte growth factor-2 leukemia inhibitory factor LIFleukemia inhibitory factor management MECP2methyl-CpG binding protein 2 Mesenchymal stem cells methyl-CpG binding protein 2 Microvesicles Moderna Mortality MSCs MSCs therapy MSCsmesenchymal stem cells MVsmicrovesicles National Institutes of Health nerve growth factor NGFnerve growth factor NIHNational Institutes of Health nitric oxide associated 1 NLR family pyrin domain containing 3 NLRP3NLR family pyrin domain containing 3 NOA1nitric oxide associated 1 organ damage organ injury P4HA1prolyl 4-hydroxylase subunit alpha 1 PDGFplatelet-derived growth factor Pfizer PGE2prostaglandin E2 phosphatase and tensin homolog platelet-derived growth factor Preclinical Preferred reporting items for systematic reviews and meta-analyses PRISMAPreferred reporting items for systematic reviews and meta-analyses proinflammatory prolyl 4-hydroxylase subunit alpha 1 prostaglandin E2 PTENphosphatase and tensin homolog Pulmonary infection Randomized controlled trial RCTrandomized controlled trial S-proteinspike protein SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SEMA3Asemaphorin 3 A semaphorin 3 A severe acute respiratory syndrome coronavirus 2 sialyl Lewis X signal transducer and activator of transcription 3 SLeXsialyl Lewis X Spike protein spread of COVID-19 STAT3signal transducer and activator of transcription 3 stem cell TGF-β1transforming growth factor β1 TGFBR1transforming growth factor β receptor I Therapies therapy tissue regeneration TLR4toll-like receptors 4 TMPRSS2transmembrane protease serine protease 2 TNFTumor Necrosis Factor toll-like receptors 4 transforming growth factor β receptor I transforming growth factor β1 transmembrane protease serine protease 2 tumor necrosis factor utility Vaccine Vaccines vascular cell adhesion molecule vascular endothelial growth factor VCAMvascular cell adhesion molecule VEGFvascular endothelial growth factor
[DOI] 10.1016/j.phrs.2022.106334 [Article Type] Review article