Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster modelsArticle Published on 2022-09-012022-11-15 Journal: EBioMedicine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Alpha variant Anti-vector immunity applicability benefit cellular immunity coronavirus COVID-19 vaccine Dual vaccine Efficacy evaluated Fever hamster hamsters highly pathogenic humoral Immunity induce Infection interfere Liver disease mice platform pre-existing immunity PROTECT resulting SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 vaccines single dose subsequent vaccination Vaccine vaccine candidate Vaccines Viral vector vaccine virus virus infection yellow fever Yellow fever vaccine. [DOI] 10.1016/j.ebiom.2022.104240 PMC 바로가기
A potent virucidal activity of functionalized TiO2 nanoparticles adsorbed with flavonoids against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Applied Microbiology and Biotechnology [Category] SARS, 치료제, [키워드] ACE-2 ACE-2 receptor Adsorption angiotensin-converting enzyme-2 Anti-SARS-CoV-2 Activity antiviral activity Antiviral effect antivirals binding block caused Cell Cell culture cell entry coronavirus SARS-CoV-2 COVID-19 Critical death demonstrated develop displaying Effect event Flavanone-7-O-glucoside flavonoid HCoV 229E Hesperetin-7-rutinoside host cell impair impairing imperative in vitro induce interact Interaction interfere management mechanism mental health molecular docking analysis Nanoparticulate compound pandemic receptor Region SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein. spike glycoprotein Spread supportive care targeted therapy the SARS-CoV-2 viral infection virucidal [DOI] 10.1007/s00253-022-12112-9 PMC 바로가기
Affinity of anti-spike antibodies to three major SARS-CoV-2 variants in recipients of three major vaccines Research Published on 2022-08-252022-10-05 Journal: Communications Medicine [Category] 진단, [키워드] ACE2 adaptive affinity Anti-spike anti-spike antibody anti-viral antibody antibody apparent affinity approach binding blocking blood plasma COVID-19 Delta determine develop domain epitope human serum humoral immune response Immunity immunogenic Infection interfere janssen Microparticle Microscope Moderna offer omicron Pfizer Pfizer/BioNTech Protein Quantitative RBD recipient reduced Result SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 virus serum the RBD the spike protein Vaccine vaccine-induced antibody Vaccines variants variety virus [DOI] 10.1038/s43856-022-00174-9 [Article Type] Research
Butein as a potential binder of human ACE2 receptor for interfering with SARS-CoV-2 entry: a computer-aided analysisSARS-CoV-2 진입을 방해하기 위한 인간 ACE2 수용체의 잠재적 결합제로서의 부테인: 컴퓨터 지원 분석Article Published on 2022-08-242022-09-11 Journal: Journal of molecular modeling [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin antiviral activity atomic level Butein clinical trials Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated dietary supplement drug candidate effective examined hACE-2 hACE2 hACE2 receptor herbal compound herbal compounds host cell host cells human ACE2 receptor human Angiotensin-converting enzyme In silico methods Infection infections Interaction interfere molecular molecular docking molecular dynamics Molecular modeling natural natural products pathogen Pathogens physicochemical Phytoconstituents profile receptor Recognition researcher SARS-CoV-2 screened selected severe acute respiratory syndrome Coronavirus shown Spike protein subset target protein therapeutic these compound these compounds viral entry viral particle Viral particles zoonotic [DOI] 10.1007/s00894-022-05270-0 PMC 바로가기 [Article Type] Article
Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian CellsArticle Published on 2022-08-242022-11-16 Journal: Biomolecules [Category] SARS, 변종, [키워드] accumulation assist B.1.351 B.1.351 variant cells chaperone chaperones contribute correlated COVID-19 diagnostic diagnostics disulphide bond domain E484K E484K mutation effort Endoplasmic reticulum expressed fusion Impact interfere mammalian mammalian cells misfolding mutant Mutation PDIA2 producing Production Protein protein disulphide isomerase protein yield. protocols RBD RBD mutation RBD protein RBD-Fc fusion protein recombinant recombinant RBD protein reduced resulting SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant secretion the RBD unfolded protein response UPR upregulation Vaccine variants [DOI] 10.3390/biom12091170 PMC 바로가기
The Acid Ceramidase Is a SARS-CoV-2 Host Factor산성 세라미다제는 SARS-CoV-2 숙주 인자입니다Article Published on 2022-08-152022-09-11 Journal: Cells [Category] SARS, 변종, [키워드] accelerated acid acid sphingomyelinase Analysis biochemical ceramidase ceramide Ceramides COVID-19 pandemic deacidify described down-regulate Effects enrichment Factor Fluoxetine fluoxetine. genomic Host hypothese hypotheses infected cells inhibit inhibitor interfere Lower lysosomal mRNA mRNAs Omicron variants ORF3 Protein reduce Replication reported RNA SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variants shown specific acid Support therapeutic strategy transmission rates Treatment variant viral entry viral gene expression viral replication [DOI] 10.3390/cells11162532 PMC 바로가기 [Article Type] Article
Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies항균제 내성에 대한 나노바이오틱스: 나노 소재 및 기술의 힘 활용Review Published on 2022-08-122022-09-11 Journal: Journal of Nanobiotechnology [Category] SARS, 유전자 메커니즘, [키워드] Antibiotic resistance Antibiotics anticipated antimicrobial resistance Antimicrobials Bacteria Bacterial Efficacy functional interfere lack mechanism MOST nanomaterials Nanotechnology pandemic Pathogens penetration positioned SARS-CoV2 shape situation spasmodic surface chemistry treat verge [DOI] 10.1186/s12951-022-01573-9 PMC 바로가기 [Article Type] Review
Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron VariantSARS-CoV-2 변이체의 스파이크 단백질에서 짧은 선형 모티프의 컴퓨터 분석은 Omicron 변이체의 면역 하이잭 및 회피 메커니즘에 대한 가능한 단서를 제공합니다Article Published on 2022-08-082022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, [키워드] Affect approach binding cellular interaction cellular pathways Coronaviruses COVID-19 eukaryotic facilitate Host host protein host proteins immune functions information interfere intracellular proteins intracellular signaling linear motif motifs omicron potential therapeutic target potential therapeutic targets Protein protein-protein interaction regulate SARS-CoV-2 SARS-CoV-2 variants sequence Sequence analysis significantly SLiMs Spike protein Spike proteins the SARS-CoV-2 the Spike Transmission variant variants viral infection virus [DOI] 10.3390/ijms23158822 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysisSARS-CoV-2 엔도리보뉴클레아제 표적화: 체외 분석으로 지원되는 구조 기반 가상 스크리닝Article Published on 2022-08-032022-09-11 Journal: Scientific Reports [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] Analysis approach Bank binding affinity binding energy cell line Compound compounds Concentration COVID-19 database deep learning Defense Diversity docking drug Drug Bank drug candidate endoribonuclease evade FIVE followed by Hierarchical Host host defense in vitro in vivo inhibitory concentration Interaction interfere life cycle molecular non-structural protein non-structural proteins Nsp15 Precision predict protocol responsible SARS-CoV-2 screened selectivity index shown supported targeting the binding affinity therapeutic effect Viral RNA Virtual screening virus was used were used [DOI] 10.1038/s41598-022-17573-6 PMC 바로가기 [Article Type] Article
Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo생체 내에서 오미크론, 델타 SARS-CoV-2 변이체 및 인플루엔자 A 바이러스에 대한 펩티드 결함 간섭 유전자 나노입자Article Published on 2022-08-032022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 변종, 신종인플루엔자, 치료제, [키워드] A549 A549 cells airway Alpha Antiviral Cell Delta demonstrated dose drug delivery system gene delivery Gene Expression Gene therapy in vivo Influenza influenza A virus Influenza virus inhibit inhibit SARS-CoV-2 interfere lung Lungs mice omicron Omicron variants peptide-based prophylactically PROTECT provide Replication replication of SARS-CoV-2 respiratory tract respiratory viruses SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants significantly variant viral challenge viral genome viral replication virus wild-type [DOI] 10.1038/s41392-022-01138-0 PMC 바로가기 [Article Type] Article