A Novel Quantitative Multi-Component Serological Assay for SARS-CoV-2 Vaccine EvaluationSARS-CoV-2 백신 평가를 위한 새로운 정량적 다성분 혈청학적 분석Article Published on 2022-03-152022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료법, [키워드] Accuracy Algorithm Analysis anti-SARS-CoV-2 array assays carried clinical trials conditions COVID-19 exposure times fluorescent generate house humoral Humoral response IgA IgG IgM Immunoglobulin immunoglobulins International international standard linear linearity methodology Microarray naïve normalized novel Nucleocapsid proteins positive Precision q-RT-PCR qRT-PCR quantitation Quantitative Receptor binding domain Result SARS-CoV-2 SARS-CoV-2 patients SARS-CoV-2 spike SARS-CoV-2 vaccines sera seroconverted serum Specific specificity the microarray the SARS-CoV-2 the WHO unique Vaccine [DOI] 10.1021/acs.analchem.1c05264 PMC 바로가기 [Article Type] Article
Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds표준화된 정량적 중화 분석을 사용하여 우려되는 SARS-CoV-2 변이체의 중화 계층은 질병 심각도와의 상관관계를 보여줍니다. 보호항체 역치를 해독하기 위해Article Published on 2022-03-072022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) 20/136 Alpha anti-SARS-CoV-2 anti-SARS-CoV-2 immunoglobulin antibody Antibody titre Asymptomatic B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta Cohort concern convalescent sera correlates of protection (CoP) COVID-19 Critical care Delta did not produce disease disease severity First wave Gamma HCW HCWs healthcare worker Healthcare workers hierarchy Immunoglobulin individual International international standard international units IU/mL K417N Laboratory laboratory findings mild case mild cases National neutralisation neutralise P.1 Pseudotyped virus pursuit reduction in SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera severe COVID-19 Standard Symptoms the WHO threshold titre titres to define unit utilised variants variants of concern variants of interest VoC VOCs WHO World Health Organisation [DOI] 10.3389/fimmu.2022.773982 PMC 바로가기 [Article Type] Article
The Comparability of Anti-Spike SARS-CoV-2 Antibody Tests is Time-Dependent: a Prospective Observational StudyAnti-Spike SARS-CoV-2 항체 검사의 비교 가능성은 시간에 따라 달라집니다: 전향적 관찰 연구Observational Study Published on 2022-02-232022-09-12 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Abbott agreement antibody Antibody assays antibody levels Antibody test antibody tests AZD1222 binding antibody Blood blood collection booster changed clinical setting clinical settings clinician comparability correlation dependent on evaluated first dose greater homologous Initially International international standard Neutralization assay observational study participant Prospective prospective observational study provided quantified Quantitative Roche SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antibody test SARS-CoV-2 antibody tests second dose serology significantly Standardization Test the timing time-dependency vaccination Withdrawal [DOI] 10.1128/spectrum.01402-21 PMC 바로가기 [Article Type] Observational Study
COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method건조 튜브 시편 방법을 사용한 COVID-19 혈청학 제어판Short Report Published on 2022-02-072022-09-10 Journal: The American Journal of Tropical Medicine and Hygi [Category] 진단, 치료법, [키워드] acute respiratory syndrome Antibody Units Antigen benefit binding antibody unit coded cold chain Control convalescent coronavirus COVID-19 Deterioration develop domain DTS FIVE greater IgG IgM Immunoglobulin international standard Laboratory Laboratory testing nucleocapsid offer Panel provide Quality assurance reactivity respiratory Sample serological test serology severe acute respiratory syndrome Coronavirus specimen Standard subtype the WHO total Ig was used [DOI] 10.4269/ajtmh.21-1036 PMC 바로가기 [Article Type] Short Report
Clinical Utility of Elecsys Anti-SARS-CoV-2 S Assay in COVID-19 Vaccination: An Exploratory Analysis of the mRNA-1273 Phase 1 TrialCOVID-19 백신 접종에서 Elecsys Anti-SARS-CoV-2 S 어세이의 임상적 유용성: mRNA-1273 1상 시험의 탐색적 분석Clinical Trial Published on 2022-01-192022-09-11 Journal: Frontiers in Immunology [Category] 임상, 치료기술, [키워드] 2019-nCoV absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-SARS-CoV-2 S antibody antibody levels automated baseline choice clinical clinical utility collected coronavirus correlated correlation COVID-19 Day detectable dose Elecsy ELISA ELISAs first vaccination geometric mean geometric mean concentration healthy heterogeneous humoral immune response increases in injection International international standard mRNA mRNA-1273 nanoluciferase neutralization test neutralization tests Neutralizing antibodies participant Participants Phase 1 phase 1 trial Protein pseudovirus neutralizing antibody pseudovirus neutralizing antibody assay quantification Quantitative quantitative serology RBD RBD ELISA RBD-specific antibodies RBD-specific antibody Receptor binding domain respiratory Result Roche S-2P Sample SARS-CoV-2 second vaccination Seroconversion seroconverted severe acute respiratory syndrome Coronavirus shown specific antibodies specificity Spike protein the Spike U/mL vaccination Vaccine vaccine-induced antibody response WHO [DOI] 10.3389/fimmu.2021.798117 PMC 바로가기 [Article Type] Clinical Trial
Evaluation of Commercial Anti-SARS-CoV-2 Antibody Assays and Comparison of Standardized Titers in Vaccinated Health Care Workers상업용 Anti-SARS-CoV-2 항체 분석 평가 및 예방 접종을 받은 의료 종사자의 표준화된 역가 비교Article Published on 2022-01-192022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott acute respiratory syndrome anti-RBD antibody Antibody titers antigens assays BAU binding bioMérieux calibration Care commercial assays convalescent individuals conversion factor Coronavirus-2 correlated detect DiaSorin dose evaluated Express FIVE HCW Health Health care Health care worker health care workers Health Organization immunization immunoassay include individuals Infection international standard naïve individuals Pearson correlation coefficient provided quantification Quantitative quantitative assay Quantitative assays RBD RBD IgG Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 antibodies sera Seroconversion Siemen Siemens Siemens Healthineer significant difference significant differences spike glycoprotein spike IgG Standard Standardization standardized titers titer vaccination Vaccine Vaccines was used were measured worker World Health Organization [DOI] 10.1128/JCM.01746-21 PMC 바로가기 [Article Type] Article
Evaluation of Three Quantitative Anti-SARS-CoV-2 Antibody Immunoassays3가지 정량적 항-SARS-CoV-2 항체 면역분석법의 평가Research Article Published on 2021-12-222022-09-10 Journal: Microbiology Spectrum [Category] SARS, 진단, 치료기술, [키워드] (Abbott Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody titer Antibody titers Antigen binding antibodies caused Chemiluminescent assay convalescent plasma coronavirus correlated correlation COVID Critical detect determine DiaSorin ELISA evaluated herd immunity house identify IgG Immunity immunization immunoassay Infection International international standard less LIAISON Live virus monoclonal antibodies Neutralization assay Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers NIBSC not correlated pandemic performed Postinfection proportional bias Protective respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 strain sensitivities sensitivity sera serological Serological assay serological assays serological result serological results severe acute respiratory syndrome Coronavirus significantly Specificities specificity spike tested the immunoassay the SARS-CoV-2 Treatment vaccination virus neutralization assay virus neutralization assays Virus spike WHO [DOI] 10.1128/spectrum.01376-21 PMC 바로가기 [Article Type] Research Article
Calibration of two validated SARS-CoV-2 pseudovirus neutralization assays for COVID-19 vaccine evaluationCOVID-19 백신 평가를위한 두 개의 검증 된 SARS-COV-2 슈도 바이러스 중화 분석의 교정Comparative Study Published on 2021-12-142022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 변종, 임상, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibodies approach assays Biomarker calibrated calibration convalescent sera COVID-19 COVID-19 vaccine COVID-19 vaccines Decision-making Efficacy evaluate Health Organization Immunoglobulin international standard licensure mRNA mRNA-1273 NAb NAb titers NAbs Neutralization assay neutralization assays Neutralizing antibodies neutralizing antibody observé overcome performed Phase 3 SARS-CoV-2 neutralization SARS-CoV-2 pseudovirus sera Standard Trial United State United States Vaccine vaccine efficacy vaccinee Vaccines World Health Organization’ [DOI] 10.1038/s41598-021-03154-6 PMC 바로가기 [Article Type] Comparative Study
Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases중증, 중등도 및 경증 COVID-19 사례의 회복기 샘플에서 SARS-CoV-2 감염의 혈청학적 바이오마커 분석Comparative Study Published on 2021-11-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome addition antibodies antibody Antibody binding antibody levels Antibody Response Antibody responses Antibody Units Antigen Asymptomatic asymptomatic infection average BAU binding antibodies binding antibody binding antibody units Biomarker Biomarkers candidate Clinical severity convalescent sera correlated correlates of protection COVID-19 COVID-19 disease COVID-19 immune response COVID-19 pandemic COVID-19 patients Electroporation ELISA epidemiological studies Epidemiological study flow cytometry HCW healthcare worker Humoral immunity identify IgA IgM increasingly International international standard international units Lateral flow test microneutralisation test Mild mild or asymptomatic infections multiplex neutralisation neutralisation assay Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses nucleocapsid positive correlation Prevalence protection pseudotyped RBD Re-infection respiratory Sample SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2-specific IgG Serological biomarkers SEROLOGICAL STUDY seronegative seropositive Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severe COVID-19 patient severe COVID-19 patients severity significantly higher spike statistically to define unit vaccination Vaccine vaccine trial variants of concern Virus neutralisation virus neutralisation assay virus neutralising antibody VoC were expressed WHO WHO guideline WHO International Standard World Health Organisation [DOI] 10.3389/fimmu.2021.748291 PMC 바로가기 [Article Type] Comparative Study
Preliminary evidence of blunted humoral response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with ocrelizumab오크렐리주맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신에 대한 체액 반응 둔화의 예비 증거Article Published on 2021-09-012022-09-11 Journal: Neurological Sciences [Category] MERS, SARS, 진단, 치료기술, [키워드] all subject all subjects Anti-spike anti-Spike IgG Antibody Units baseline BAU binding antibody units BNT162b2 Case series case sery collected COVID-19 COVID-19 infection develop DiaSorin disease expand first dose geometric geometric mean health-care healthy subject healthy subjects humoral Humoral response IgG antibodies IgG antibody immunogenicity Infection International international standard majority mounted mRNA mRNA vaccine Multiple multiple sclerosis Ocrelizumab patients treated preliminary evidence relapsing SARS-CoV-2 SARS-CoV-2 mRNA vaccine SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARSCoV-2 second dose second dose of vaccine sera serum sample serum samples Spike protein tested Therapies treated unit Vaccine were expressed [DOI] 10.1007/s10072-021-05397-7 PMC 바로가기 [Article Type] Article