Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation Research Published on 2022-06-222022-10-05 Journal: Acta pharmacologica Sinica [Category] 바이오마커, [키워드] activated Activation addition administration ameliorated Analysis Anti-inflammatory Apoptosis Caco-2 cells Cell cell proliferation Colitis Colon colonic comparable degranulation down-regulated downstream gene downstream signaling pathways epithelial expression in vitro in vivo inactivation Inflammation inhibited inhibiting injection intestinal intestinal inflammation investigated involved MAPK mechanism neutrophil neutrophil degranulation neutrophil recruitment NF-κB prevented pro-inflammatory cytokine promoted Protein Proteins proteomic recruitment regulated restored S100A9 signaling pathway significantly suppressed therapeutic therapeutic effect TLR4 [DOI] 10.1038/s41401-022-00933-3 [Article Type] Research
SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytesArticle Published on 2022-04-192023-06-15 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), MERS, SARS, [키워드] COVID‐19 digestive system GI symptoms intestinal inflammation Microbiology, Virology & Host Pathogen Interaction Vascular Biology & Angiogenesis vascular permeability VEGF [DOI] 10.15252/emmm.202114844 PMC 바로가기 [Article Type] Article
All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐κB Signaling PathwayImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] acid Activation all-trans retinoic acid anti-inflammatory activity ATRA attenuate Cell cells damaged downregulated downstream economic loss epithelial epithelial cell gastroenteritis IL-1β IL-6 IL-8 immunomodulatory properties indicated Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibiting inhibitor Injury intestinal intestinal inflammation IPEC-J2 cells damage knockdown MAVS MDA5 mechanism molecular mechanism mRNA abundance mRNA expression NF-κB nuclear translocation occludin p65 Pathogenesis Phosphorylation prevented pro-inflammatory cytokines protective effect protein level reduced reduction resulting reversed RIG-I RLRs/NF‐κB pathway signaling molecule signaling pathway significantly Suppressing TGEV TLR3 TLR7 TNF-α Traf6 transmissible gastroenteritis virus Treatment TRIF triggered upregulation ZO-1 [DOI] 10.3389/fimmu.2022.734171 PMC 바로가기 [Article Type] Immunology
Salmonella enterica serovar Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance살모넬라 엔테리카 세로바르 타이피무리움은 프로피온산 매개 대장 내 저항을 극복하기 위해 혐기성 호흡을 사용한다.Article Published on 2022-01-042024-08-21 Journal: Cell Reports [Category] 살모넬라증, [키워드] colonization resistance gut microbiota intestinal inflammation microbial metabolism propionate. Salmonella
Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamstersResearch Article Published on 2021-12-292022-10-31 Journal: Gut Microbes [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome alteration approach Bacteria Bacterial change characterized controls coronavirus coronavirus disease correlation Course COVID-19 Critical decrease Deleterious disease disease severity Enterobacteriaceae enzyme Evidence evidenced fatty Fatty acid feature Gut gut microbiota gut microbiota composition had no hallmark hamster hamsters homeostasis human disease Infection Inflammation inflammatory parameters intestinal intestinal inflammation lipid metabolism liver Lungs markers of disease severity Mild Mounting non-infected occurred outcomes polymerase chain proportion question reduced respiratory viral infections reverse transcription RT-PCR SARS-CoV-2 SARS-COV-2 infection SCFAs severity TMPRSS2 transmembrane serine protease [DOI] 10.1080/19490976.2021.2018900 PMC 바로가기 [Article Type] Research Article
Mobility of β -lactam resistance under ampicillin treatment in gut microbiota suffering from pre-disturbance암피실린 치료 중 미리 교란된 장내 미생물군에서 β-락탐 내성의 이동성Article Published on 2021-12-092024-07-29 Journal: Microbial Genomics [Category] 살모넬라증, [키워드] Antibiotic resistance Antibiotic treatment gut microbiota intestinal inflammation plasmid transfer [DOI] 10.1099/mgen.0.000713 PMC 바로가기
Xylo-oligosaccharide alleviates Salmonella induced inflammation by stimulating Bifidobacterium animalis and inhibiting Salmonella colonizationarticle Published on 2021-11-302024-09-01 Journal: The FASEB Journal [Category] 살모넬라증, [키워드] adhesibility Bifidobacterium animalis intestinal inflammation Salmonella Typhimurium xylo-oligosaccharide [Article Type] article
Herbal Medicine, Gut Microbiota, and COVID-19Pharmacology Published on 2021-07-072022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accelerate ACE2 acute respiratory syndrome affected amino acid malnutrition angiotensin converting enzyme caused complications coronavirus cough COVID-19 demonstrated diarrhea enteric symptom expressed Fever gastrointestinal tract gut microbiota Herb Herbal herbal medicine immune function intestinal cells intestinal flora intestinal inflammation intestinal mucosal barrier life threatening main receptor Medicine microbial mild flu-like symptoms modulate Mortality nausea organ patients with COVID-19 progression regulate Respiratory disease Respiratory virus infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus significantly symptoms of COVID-19 the disease treating COVID-19 Treatment understanding virus vomiting worldwide pandemic [DOI] 10.3389/fphar.2021.646560 PMC 바로가기 [Article Type] Pharmacology
Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19급성 COVID-19 환자에서 설사, 대변 바이러스 RNA 및 SARS-COV-2- 특이 적 IGA에도 불구하고 제한된 장 염증Article Published on 2021-06-252022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료제, [키워드] acute COVID-19 Antibody Response Antibody responses characterized Cohort controls COVID-19 disease COVID-19 patient COVID-19 patients Cytokines detected in stool diarrhea died difficulty Evidence evidence of fecal Gastrointestinal gastrointestinal symptoms gastrointestinal tract Gut hospitalized COVID-19 patients IgA IgA response IL-10 IL-23 IL-8 immune response individual infected individuals Infection Inflammation inflammatory markers intestinal Intestinal diseases intestinal inflammation Limited microbiome composition Mucosal immunology nasopharynx Patient SARS-CoV-2 SARS-CoV-2 RNA severe COVID-19 disease severe disease specimen Stool stool samples strain Strains survived Symptom tissue samples Translational research uninfected Viral Viral RNA [DOI] 10.1038/s41598-021-92740-9 PMC 바로가기 [Article Type] Article
Pediatric Multisystem Inflammatory Syndrome in Children as a Challenging Problem for Pediatric Surgeons in the COVID 19 Pandemic—A Case ReportPediatrics Published on 2021-06-112022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] abdominal pain acute respiratory syndrome affected Appendectomy Asymptomatic Atypical Case report caused children Comorbidities coronavirus disease Coronavirus disease-19 Coronavirus-2 Course COVID 19 COVID-19 diagnosed Diagnosis differential diagnosis disease hospital illness include individual infected with SARS-CoV-2 Infection Inflammatory inflammatory markers Initially intestinal inflammation Kawasaki syndrome majority mortality rate pediatric Pediatric case Pediatric Inflammatory Multisystem Syndrome PIMS presenting problem report Respiratory failure SARS-CoV-2 SARS-COV-2 infection Spread surgical Symptom symptomatic Symptoms syndrome Treatment [DOI] 10.3389/fped.2021.677822 PMC 바로가기 [Article Type] Pediatrics