Mass Switch From Intravenous to Subcutaneous Tocilizumab in Rheumatic Diseases During the SARS-COV-2 PandemicArticle Published on 2022-10-012022-11-15 Journal: Journal of clinical rheumatology : practical reports on rheumatic & [Category] COVID19(2023년), SARS, 진단, [키워드] administration adverse event Analysis Cell COVID Critical disease effective Follow-up Giant giant cell arteritis headache hospital injection intravenous juvenile idiopathic arthritis mass pandemic Patient remained rheumatoid arthritis rheumatological patient rheumatology Safe Subcutaneous subgroup analysis switch switching Systemic sclerosis TCZ the SARS-CoV-2 Tocilizumab Treatment was performed [DOI] 10.1097/RHU.0000000000001862 PMC 바로가기
Nafamostat Mesylate for Treatment of COVID-19 in Hospitalised Patients: A Structured, Narrative ReviewArticle Published on 2022-10-012022-11-15 Journal: Clinical pharmacokinetics [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome addition Antithrombotic Antiviral antiviral potency benefit cell line cellular clinical Clinical outcome clinical study clinical trial clinically Coronavirus-2 COVID-19 disease Disseminated intravascular coagulation drug effective Efficacy enzyme human cells human lung hypothesised indication inhibitory concentration intravenous investigated Japan Laboratory mesylate nafamostat Nafamostat mesylate narrative patients with moderate pharmacokinetic protease recruitment Remdesivir repurposing review robust SARS-CoV-2 serine 2 severe COVID-19 TMPRSS2 transmembrane treatment for COVID-19 viral entry [DOI] 10.1007/s40262-022-01170-x PMC 바로가기
Current evidence on the use of anakinra in COVID-19Review article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 임상, 진단, 치료제, [키워드] acute respiratory distress syndrome administration Anakinra approval clinical evidence clinical status COVID-19 COVID-19 patient COVID-19 patients current cytokine cytokine release Cytokine release syndrome Cytokine storm dose early stage effective Evidence IL-1 IL-1 receptor antagonist Immunomodulatory agent include inhibit interleukin-1 intravenous knowledge management mechanical ventilation multiple organ failure off-label Prevent progression Remdesivir required secondary hemophagocytic lymphohistiocytosis shown syndrome the disease the SARS-CoV-2 therapeutic effect therapeutic effects therapy Treatment treatment approach viral replication [DOI] 10.1016/j.intimp.2022.109075 [Article Type] Review article
Development and characterization of anti-SARS-CoV-2 intravenous immunoglobulin from COVID-19 convalescent plasmaArticle Published on 2022-10-012022-11-15 Journal: Immunotherapy [Category] COVID19(2023년), SARS, 진단, [키워드] administration Adults allergenic animal models anti-SARS-CoV-2 clinical trial Concentration convalescent plasma COVID-19 COVID-globulin development developmental Efficacy hamster healthy hyperimmune hyperimmune immunoglobulin IgG Immunoglobulin immunoglobulin against COVID-19 Immunosuppressed inactivation intravenous Intravenous immunoglobulin investigated material Neutralizing plasma preclinical evaluation produced Protective protective efficacy. Protein purification Safe Safety SARS-CoV-2 SARS-CoV-2 neutralizing antibody Toxicity virus [DOI] 10.2217/imt-2022-0015 PMC 바로가기
Preclinical safety evaluation and tracing of human mesenchymal stromal cell spheroids following intravenous injection into cynomolgus monkeysResearch article Published on 2022-10-012022-10-05 Journal: Biomaterials [Category] Coronavirus, 비임상, [키워드] addressed administration ambient Blood blood vessel Cell death demonstrated dissociate Efficacy feasible Host hypoxic condition injection intravenous Intravenous injection less lung Mesenchymal stem cells mice Monkey MSC MSCs multiple sclerosis occurred Osteoarthritis physiological change Preclinical promote retention Safe Safety Single Cell small blood vessel small vessel Spheroid Stress stromal cell survival viability wound healing [DOI] 10.1016/j.biomaterials.2022.121759 [Article Type] Research article
Study protocol for a pilot randomized controlled trial to increase COVID-19 testing and vaccination among people who inject drugs in San Diego CountyArticle Published on 2022-09-052022-10-05 Journal: Addiction Science & Clinical Practice [Category] SARS, 임상, [키워드] analyses Antigen board cohort study Community condition COVID-19 COVID-19 testing COVID-19 vaccination develop Diego drug effect size Efficacy estimate event facilitate finding Follow-up harm reduction health authorities Health status impacted include information intake Intervention intravenous lesson Local Motivational interviewing offer organization outcomes participant pilot study Population populations Precision protocol Randomized Randomized controlled trial RCT recruit reduction Registered SARS-CoV-2 severe disease state health department Study design substance Substance use Support Trial vaccination vulnerable populations. [DOI] 10.1186/s13722-022-00328-z PMC 바로가기 [Article Type] Article
Clinically Relevant Interactions Between Ritonavir-Boosted Nirmatrelvir and Concomitant Antiseizure Medications: Implications for the Management of COVID-19 in Patients with EpilepsyArticle Published on 2022-09-012022-11-15 Journal: Clinical pharmacokinetics [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] administration anti-SARS-CoV-2 Antiviral bidirectional boost Clinical efficacy clinically complicate Concentration Concomitant concomitant treatment country COVID-19 CYP3A4 dosing interval drug-drug interaction Efficacy European Evidence high risk information inhibitor intravenous involved medication molnupiravir Nirmatrelvir Patient patients treated persistence plasma plasma concentration Remdesivir Ritonavir severe COVID-19 disease subject substrates the SARS-CoV-2 virus Toxicity Treatment [DOI] 10.1007/s40262-022-01152-z PMC 바로가기
HERPES-LIKE LESIONS IN PATIENTS WITH COVID-19: REPORT OF FOUR CASES AND TREATMENT APPROACHConference abstract Published on 2022-09-012022-10-05 Journal: Oral surgery, oral medicine, oral pathology and or [Category] 치료법, [키워드] age antimicrobial Comorbidity contribute Critical dentist diagnosed Diagnosis female Health highlight hospital Hospitalization IMPROVE intensive care intravenous lesion male mechanical ventilation Oral hygiene oral manifestation oral mucosa Patient patients with COVID-19 polymerase chain Rapid reduce severe COVID-19 severe disease therapy was performed [DOI] 10.1016/j.oooo.2022.01.393 [Article Type] Conference abstract
Dispensing anti-osteoporotic drugs changed during the COVID-19 pandemicCOVID-19 대유행 기간 동안 변경된 골다공증 치료제 조제Observational Study Published on 2022-09-012022-09-12 Journal: Bone [Category] 임상, 진단, 치료제, [키워드] alendronate alteration Analysis Anti-osteoporotic therapy ARIMA Austria Autoregressive integrated moving average models average bisphosphonate Bisphosphonates changed clinician COVID-19 COVID-19 pandemic declined decrease Dispensing DMAB drug estrogen receptor intravenous lockdown medication Non-COVID-19 observation occurred Osteoporosis Osteoporosis. pandemic Patient patients treated predict predicted prescription Pseudonymised repeated retrospective risk selective Treatment treatment regimen [DOI] 10.1016/j.bone.2022.116477 PMC 바로가기 [Article Type] Observational Study
Comparison of the effect of intravenous dexamethasone and methylprednisolone on the treatment of hospitalized patients with COVID-19: a randomized clinical trialRandomized Controlled Trial Published on 2022-09-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 바이오마커, 임상, 치료법, [키워드] addition Admission age analysis of variance analyzed assigned confidence interval COVID-19 Dexamethasone doses duration of hospitalization Effect Effectiveness enrolled Hospital stay Hospitalization hospitalized patient hyperglycemia hypokalemia Inpatient intensive care intravenous leukocyte Lymphocyte count Methylprednisolone methylprednisolone group methylprednisolone. moderate Mortality mortality rate Oxygen therapy Patient Primary outcome protocol randomized clinical trial Randomly Result secondary outcome severe COVID-19 significantly SPSS statistically significant t-test therapeutic Treatment two group with COVID-19 [DOI] 10.1016/j.ijid.2022.07.019 PMC 바로가기 [Article Type] Randomized Controlled Trial