Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot studySARS-COV-2 감염 및 급성 신장 손상 마커에 의해 유도 된 변경된 신장 기능 COVID-19 환자의 생존 결과를 예측합니다 : 전향 적 파일럿 연구Article Published on 2022-12-012022-08-31 Journal: Renal failure [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute kidney Acute kidney injury adjusted Advancing age Altered Analysis association Biomarker chronic Chronic kidney disease collaboration Comorbidities Comorbidity Control coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 COVID-19 patient COVID-19 patients creatinine Cumulative rates cystatin C death demonstrated elevated examined group groups Hospitalized ICU intensive care intensive care unit investigated Kaplan-Meier method kidney kidney damage Kidney disease Kidney function Kidney function tests Kidney injury literature marker morbidity multivariable Cox regression outcome participant pilot study predict Predictive Predictive value Proteinuria retained risk factor Risk factors SARS-COV-2 infection serum serum creatinine Sex significant difference statistically subject survival survival analysis survival analysis. the Kaplan-Meier method Treatment Urine with COVID-19 [DOI] 10.1080/0886022X.2022.2032743 PMC 바로가기 [Article Type] Article
Human parainfluenza 3 and respiratory syncytial viruses detected in pangolins천산갑에서 검출된 인간 파라인플루엔자 3 및 호흡기 세포융합 바이러스Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료기술, [키워드] approaches died Diseases eight Evidence Host hRSV Human human parainfluenza virus human respiratory diseases identity Infection investigated metagenomic metagenomic sequencing nucleotide Other respiratory viruses pangolin pangolins parainfluenza parainfluenza virus Paramyxoviridae pathogen Pathogens Phylogenetic tree Pneumonia Prevent public health related viruses respiratory diseases respiratory syncytial virus respiratory syncytial virus B respiratory viruses sequence susceptible Symptom Viral transmission virus virus virus transmission virus transmission vector whole-genome zoonotic zoonotic diseases. [DOI] 10.1080/22221751.2022.2086071 PMC 바로가기 [Article Type] Article
Population-weighted exposure to green spaces ties to lower COVID-19 mortality rates: A nationwide dose-response study in the USAResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] 유전자 메커니즘, 진단, [키워드] adjusted adopted association buffer caused chronic disease confidence interval Contact with nature COVID-19 mortality COVID-19 pandemic Critical decrease distribution ecological Effect effect size environmental factors forest greater Health increase in investigated knowledge Landscape planning and design linear mechanism mitigate mixed-effects model Mortality mortality rate mortality rates Nearby nature Optimal dose of nature promote PROTECT Regulation Research risk of COVID-19 SARS-CoV-2 Sociodemographic USA with COVID-19 [DOI] 10.1016/j.scitotenv.2022.158333 [Article Type] Research article
Early treatment of Favipiravir in COVID-19 patients without pneumonia: a multicentre, open-labelled, randomized control studyArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 95% CI adjusted hazard ratio Antiviral antiviral. ARMS clinical clinical condition Clinical improvement complications control arm COVID-19 COVID-19 patient Day defined early treatment Effect Efficacy enrolled enrolment faster Favipiravir female FPV investigated likelihood median median time mild case mild pneumonia multicentre Patient PCR-confirmed Pneumonia primary endpoint randomized control study RdRP RdRp inhibitor registry risk of COVID-19 SARS-CoV-2-infected patient score significantly higher supportive care sustained symptomatic Thailand Treatment viral clearance Viral detection [DOI] 10.1080/22221751.2022.2117092 PMC 바로가기
Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysisArticle Published on 2022-12-012022-11-16 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 치료기술, [키워드] Abnormalities acute phase acute respiratory syndrome age Analysis articles consequence Control coronavirus coronavirus disease COVID-19 COVID-19 vaccine death Effect Effects evaluate Evidence Follow-up hypogonadism increased risk Infection information intensive care unit investigated male Meta-analysis mRNA mRNA COVID-19 vaccine not affect observational study parameter parameters Patient recovering from COVID-19 reduced retrieved retrospective SARS-CoV-2 Semen Sperm systematic review Testosterone the disease vaccination. [DOI] 10.1007/s40618-022-01801-x PMC 바로가기
Molecular evidence for SARS-CoV-2 in samples collected from patients with morbilliform eruptions since late 2019 in Lombardy, northern ItalyArticle Published on 2022-12-012022-11-15 Journal: Environmental research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG association B.1 Brazil circulation collected COVID-19 database detectable anti-SARS-CoV-2 antibodies downloaded emergence evaluated Evidence group highlight IgA antibodies IgG and IgM IgM individual Infection investigated Italy Laboratory lombardy measles molecular Mutation oropharyngeal swab outbreak pandemic Patient patients PCR positive positive patient producing Rash reported retrospective RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2. screened sequence sequence information Sequencing Spread strain subjects Surveillance syndrome tested Urine virus Wuhan [DOI] 10.1016/j.envres.2022.113979 PMC 바로가기
Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysisArticle Published on 2022-12-012022-11-15 Journal: Drug Delivery [Category] COVID19(2023년), SARS, 치료제, [키워드] addition administration Analysis Antiviral antiviral activity Calu-3 Cell characterized Concentration COVID-19 cytotoxicity Favipiravir in vitro indicated Influenza virus Inhaled inhaled formulation inhibitor investigated lung lung epithelial cell lung tissue Lungs media Patient patients with COVID-19 PBS phosphate buffer profile pulmonary RdRP real time required respiratory. RNA-dependent RNA polymerase SARS-CoV-2 stability target Toxicity treat Treatment VERO-E6 viability were infected [DOI] 10.1080/10717544.2022.2118398 PMC 바로가기
Combination therapy with remdesivir and immunomodulators improves respiratory status in COVID-19: A retrospective studyArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval Analysis Baricitinib baseline benefit body mass index combination therapy Concomitant contributed control group coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Day Diabetes Mellitus examined faster greater hazard ratio immunomodulator immunomodulators IMPROVE in both group independent investigated median outcome Oxygen administration Patient patients Prognostic factors Remdesivir respiratory recovery retrospective Retrospective study severity single-center study standard treatment supplemental oxygen survival synergistic therapy Tocilizumab tocilizumab. treated two group [DOI] 10.1002/jmv.28037 PMC 바로가기
Pathogen-host adhesion between SARS-CoV-2 spike proteins from different variants and human ACE2 studied at single-molecule and single-cell levelsArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2-RBD acute respiratory syndrome addition adhere binding complex coronavirus Delta delta variant destabilized effective force spectroscopy highest host cell human ACE2 human Angiotensin-converting enzyme immunization Infection inhibit Interaction investigated molecular dynamics molecular mechanism monoclonal antibody Mutation mutations N501Y Neutralizing neutralizing antibody omicron pathogen-host adhesion. Probability produced RBD Receptor binding domain S477N SARS-CoV-2 SARS-CoV-2 spike protein single-cell single-cell level Spike protein tested the spike protein variant variants virus wild type [DOI] 10.1080/22221751.2022.2128887 PMC 바로가기
The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockadeArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome alteration analysed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-TNF-α appear Autoimmune Autoimmune diseases blockade bystander Cell changes in chronic inflammatory disease Cohort comparable Control coronavirus COVID-19 Decline drugs Effect Efficacy ELISA flow cytometry groups healthy humoral immune response IgG immune cell populations immune response immunoblot investigated less Live virus Necrosis Neutralization assay neutralize neutralizing antibody neutralizing capacity Older omicron Patient patients plasma Plasma cell recipient reduced response SARS-CoV-2 second vaccination significantly T cell subset titre TNF-α TNFα tumor necrosis factor inhibitors tumor necrosis factor-α vaccination vaccination. Vaccine variants of concern virus VoC was increased while [DOI] 10.1002/jmv.28063 PMC 바로가기