Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisationArticle Published on 2022-06-012023-07-07 Journal: British Journal of Pharmacology [Category] COVID19(2023년), [키워드] cardiac pharmacology COVID-19 Electrophysiology ion channels Mathematical modelling safety pharmacology. [DOI] 10.1111/bph.15757
Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal ComponentsReview Published on 2021-12-312022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Adverse reactions antinociceptive component Compound disease Dizziness drug Effect effective Efficacy Epidemiology Evidence facilitate glycoside Glycosides IMPROVE induce involved ion channels Laboratory mechanism membrane membrane receptors mental health Mild natural neuropathic neuropathic pain occur oedema oxidative stress Pain Patient patients peripheral pharmacological agent plant Potential Quality of life receptor Research Sedation shown therapeutic drug transcriptional regulation treat Treatment vomiting [DOI] 10.3390/molecules27010255 PMC 바로가기 [Article Type] Review
Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of DiseaseReview Published on 2021-10-272022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Anti-viral antiviral therapy cellular membranes Community conserved contribute COVID-19 pandemic creating develop domain domains Effect Endoplasmic reticulum Express facilitate feature HCV hepatitis C highlight highlighting HIV Host host membrane HPV Human hydrophilic hydrophobic IAV immune evasion immune modulation immunomodulatory effect Infection Influenza Ion ion channels ion homeostasis knowledge mechanisms papillomavirus Polyomavirus Protein Proteins reading regulate replicative Research respiratory SARS-CoV Structure target Transport Treatment Vaccine Viral immune evasion viral infection virion assembly viroporins virus viruses [DOI] 10.3390/v13112165 PMC 바로가기 [Article Type] Review
Determination of Ligand Binding Modes in Hydrated Viral Ion Channels to Foster Drug Design and Repositioning약물 디자인 및 재배치 촉진을 위한 수화된 바이러스 이온 채널의 리간드 결합 모드 결정Article Published on 2021-07-272022-09-10 Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 신약개발, 치료제, [키워드] amantadine antiviral drug atomic resolution binding bridging interaction build candidate capture channel complex complex structure complexes COVID-19 pandemic derivative Determination determined by Diversity drug drug candidate drug design Drug discovery envelope protein experiment foster help hydrocarbon hydrophobic IMPROVE Influenza influenza A investigated Ion ion channel ion channels Ligand mechanism of action mode Numerous positioned protocol Region reliability repositioning resulting SARS-CoV-2 scratch Structure structures the SARS-CoV-2 transmembrane Undetermined water water molecules waters while [DOI] 10.1021/acs.jcim.1c00488 PMC 바로가기 [Article Type] Article
Blockers of the SARS-CoV-2 3a Channel Identified by Targeted Drug Repurposing표적 약물 용도 변경으로 식별된 SARS-CoV-2 3a 채널 차단기Article Published on 2021-03-232022-08-31 Journal: Viruses [Category] SARS, 신약개발, 치료제, [키워드] antiviral drugs assays bacterial assays biosafety blocker Capreomycin channel channel blockers Coronaviridae COVID-19 pandemic Darapladib drug effort etiological agent Floxuridine Fludarabine Flumatinib Identified inhibit ion channels kasugamycin library Litronesib Measures member Membrane proteins pathogen Pentamidine Plerixafor repurposing Research SARS-CoV-2 screened spectinomycin Stage suggested the Coronaviridae the SARS-CoV-2 the stage these compound these compounds Treatment viral channels virus [DOI] 10.3390/v13030532 PMC 바로가기 [Article Type] Article
Peripheral Mechanisms of Neuropathic Pain—The Role of Neuronal and Non-Neuronal Interactions and Their Implications for Topical Treatment of Neuropathic PainReview Published on 2021-01-202024-09-02 Journal: Pharmaceuticals [Category] 대상포진, [키워드] ion channels neuropathic pain PAIN MANAGEMENT peripheral sensitization topical [DOI] 10.3390/ph14020077 PMC 바로가기 [Article Type] Review
Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular DysfunctionReview Published on 2020-10-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Activation arteries Atherosclerosis atherosclerotic plaque atherosclerotic plaques Care caused Complete coronary blood flow disease dysfunction Health heart individual ion channels Ischemic ischemic heart disease mechanism Microcirculation Myocardial infarction observation paradigm pathophysiological pathophysiological mechanism pathophysiology plaque resource [DOI] 10.3390/ijms21218118 PMC 바로가기 [Article Type] Review
Similarities between the effect of SARS-CoV-2 and HCV on the cellular level, and the possible role of ion channels in COVID19 progression: a review of potential targets for diagnosis and treatmentReview Published on 2020-10-222022-10-31 Journal: Channels [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis can be used caused cellular Combination coronavirus COVID-19 pandemic COVID19 Diagnosis drug drug target effective Evidence exhibited expand HCV hepatitis C highlight identify immune responses in viral include Inflammation ion channels ion homeostasis knowledge Medicine offer patients peg-IFN Perspective prevention of COVID-19 pulmonary system reduction reveal Ritonavir SARS-CoV-2 similarity Symptom target the disease Treatment treatment approach treatments for COVID-19 Via Viral load viruses [DOI] 10.1080/19336950.2020.1837439 PMC 바로가기 [Article Type] Review
QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID-19: The need for pharmacogenetic insightsCOVID-19 치료를 위한 하이드록시클로로퀸 및 아지트로마이신을 사용한 QT 연장: 약리학적 통찰력의 필요성Comment Published on 2020-10-012022-09-11 Journal: Journal of cardiovascular electrophysiology [Category] SARS, 유전자 메커니즘, [키워드] Abstract arrhythmia Azithromycin COVID-19 Hydroxychloroquine ion channels pharmacogenetic pharmacogenetics polymorphism QT prolongation Treatment [DOI] 10.1111/jce.14722 PMC 바로가기 [Article Type] Comment
The Role of MicroRNA in the Airway Surface Liquid HomeostasisReview Published on 2020-05-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] airway airway epithelium airway host defense airway surface liquid ASL chronic obstructive pulmonary disease composed coronavirus cystic fibrosis Defense Gene Expression homeostasis Host Host–pathogen interaction increasingly information Inhaled Innate immunity Ion ion channels liquid maintain mechanisms microRNA miRNA miRNA-mRNA interaction Mucociliary clearance pathogen PROTECT responsible RNA RNA-induced silencing complex role SARS-CoV-2 single-stranded surface therapy Volume [DOI] 10.3390/ijms21113848 PMC 바로가기 [Article Type] Review