Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer Research Published on 2022-05-042022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] appear applied approach ARHGAP26 Cancer Cell CHAF1A CNPPD1 collected complex complex disease Critical database dataset death diabete diagnostic differentially expressed gene Differentially expressed genes disease disease onset DLC1 enriched pathways event FDX1 gene expression dataset Gene expression profiling information Interaction ITGBL1 kidney Kidney diseases LAMP2 MAP3K13 MAPK molecular MTO1 NSMAF pathophysiology pathway phenotype PPP2R5E progression PRSS23 receptor renal Research reveal SCARB2 Stage STAMBP survival SYNJ1 tight junction TPGS2 YY1 [DOI] 10.1038/s41598-022-11143-6 [Article Type] Research
Characteristics and Healthcare Costs in the Aging Hepatitis B Population of Japan: A Nationwide Real-World AnalysisArticle Published on 2022-01-012023-06-13 Journal: Digestive diseases (Basel, Switzerland) [Category] B형 간염, [키워드] Chronic Hepatitis B Comorbidity Epidemiology healthcare administrative claims Kidney diseases Osteoporosis [DOI] 10.1159/000515854
Development of a prediction score for in-hospital mortality in COVID-19 patients with acute kidney injury: a machine learning approachArticle Published on 2021-12-242022-10-04 Journal: Scientific Reports [Category] SARS, 치료법, [키워드] 95% CI Accuracy acute kidney AKI approach assist build can be used category cause characteristic Characteristics coefficient Comorbidity condition COVID-19 COVID-19 patient cross-sectional defined develop development Diagnosis disease severity Elastic evaluated healthcare worker hospitalized COVID-19 patient in-hospital mortality Intensive KDIGO Kidney diseases Kidney injury Laboratory Latin America multicentre Predictive predictor variable prognostic prospective cohort study registry resource Risk factors validation cohort were used with COVID-19 [DOI] 10.1038/s41598-021-03894-5 PMC 바로가기 [Article Type] Article
Chapter One: Renal diseases and the role of complement: Linking complement to immune effector pathways and therapeuticsBook chapter Published on 2021-11-262022-10-05 Journal: Advances in Immunology [Category] 비임상, [키워드] Activation Adaptive immune response approach approved Avacopan C3 C5 Cell clinical evidence clinical trial complement complement inhibitors complement system Complosome component components conserved Critical Defense deposition eculizumab Evidence greater hallmark Host immune immunology inhibitor Innate immunity investigated Kidney disease Kidney diseases management Pathogens pathophysiological pathway Pathways phylogenetically renal disease required therapeutic agent this system tissue homeostasis tissue injury variety [DOI] 10.1016/bs.ai.2021.09.001 [Article Type] Book chapter
Single-Cell RNA Sequencing of Urinary Cells Reveals Distinct Cellular Diversity in COVID-19-Associated AKI비뇨기 세포의 단일 세포 RNA 시퀀싱으로 COVID-19 관련 AKI에서 뚜렷한 세포 다양성을 보여줍니다Article Published on 2021-11-052022-09-11 Journal: Kidney360 [Category] SARS, 치료기술, [키워드] ACE2 acute kidney Acute kidney injury acute kidney injury and ICU nephrology AKI alteration Analysis Anti-inflammatory Antiviral Basic science bladder Cell cell type cell types cells cellular collected contribute COVID-19 dataset direct infection Diversity eight enrichment Evidence evidence of Gene Expression highest hospitalized patient hospitalized patients Hypothesis ICU immune cells include infection with SARS-CoV-2 information kidney Kidney diseases Mortality Non-COVID-19 occur one patient pathophysiology pathway Pathway analysis Pathways Patient patients with AKI performed preliminary evidence resource RNA SARS-CoV-2 SARS-CoV-2 viral RNA scRNAseq severity single-cell Single-cell RNA sequencing tested TMPRSS2 TMPRSS2 expression transcript transcripts tubular cell uninjured urinary Urinary bladder urinary sediment Urine with COVID-19 [DOI] 10.34067/KID.0005522021 PMC 바로가기 [Article Type] Article
Development of the International Classification of Diseases Ontology (ICDO) and its application for COVID-19 diagnostic data analysis국제 질병 분류 온톨로지 (ICDO)의 국제 분류 개발 및 COVID-19 진단 데이터 분석에 대한 적용Research Published on 2021-10-182022-09-10 Journal: BMC Bioinformatics [Category] 치료기술, 치료제, [키워드] addressed adopted aligned analyzed annotations applied basic bioinformatics causes characterization Chinese classification clinical components country COVID-19 COVID-19 disease COVID-19 patient Data analysis dataset defined development diabetes Diagnosis diagnostic disease Disease standardization Diseases EHR English etiological Formal health problems heart ICD ICD10 ICD9 ICDO International kidney Kidney disease Kidney diseases lung mapped Occurrence ontologies Ontology organ organs other diseases over phenotype platform problem profiles provide Result reuse Signs and symptoms Symptoms use case website [DOI] 10.1186/s12859-021-04402-2 PMC 바로가기 [Article Type] Research
SNPs at 3’UTR of APOL1 and miR-6741-3p target sites associated with kidney diseases more susceptible to SARS-COV-2 infection: in silco and in vitro studiesAPOL1 및 miR-6741-3p의 3'UTR에 있는 SNP는 SARS-COV-2 감염에 더 민감한 신장 질환과 관련된 부위를 표적으로 함: in silco 및 in vitro 연구Article Published on 2021-10-012022-09-11 Journal: Mammalian genome : official journal of the Interna [Category] SARS, 변종, 치료제, [키워드] Acute kidney injury addition African American AKI angiotensin Angiotensin II APOL1 association binding binding site BRF1 calculated chemokine Chronic kidney disease CKD Collapsing control sample COVID-19 different diseases disease effective Effectiveness evaluate the effect expression first position Gene Expression genetic variants genomic sequence Genotype glomerulopathy GTF2H5 healthy HES2 identify in silico in vitro in vitro study increase increased risk Infection Interaction kidney Kidney disease Kidney diseases Kidney injury lesion Ligand likelihood MAFG Mann-Whitney U test MED12L microRNA MicroRNAs miRNA miRNAs motif NFYB nucleotide Pathways Patient Protein PRSS23 qRT-PCR relative expression reported SARS-COV-2 infection shown single-nucleotide polymorphism SLC6A19 SNP SNPs susceptibility susceptible SWT1 target target gene Target genes TLR7 TRAF3 UTR Variation with COVID-19 [DOI] 10.1007/s00335-021-09880-6 PMC 바로가기 [Article Type] Article
Clinicopathological characteristics and prognosis of hepatitis B associated membranous nephropathy and idiopathic membranous nephropathy complicated with hepatitis B virus infectionArticle Published on 2021-09-152023-06-03 Journal: Scientific Reports [Category] B형 간염, [키워드] kidney Kidney diseases Nephrology [DOI] 10.1038/s41598-021-98010-y PMC 바로가기 [Article Type] Article
Soluble urokinase plasminogen activator receptor (suPAR) predicts critical illness and kidney failure in patients admitted to the intensive care unitArticle Published on 2021-09-012022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] 28-day mortality association Coagulation consecutive patient COVID-19 Critical critically ill patients Diagnosis doubling estimate highest ICU ICU admission ICU patient Infectious diseases inflammation markers Inflammatory biomarker intensive care Interaction Kaplan–Meier kidney Kidney disease Kidney diseases Liver disease lowest moderate Mortality non-survivor Occurrence Odds ratio offer organ dysfunction Organ failure Patient performed plasma suPAR predict Prognostic markers Prognostic value Prospective Study quartile random receptor reflected risk factor risk stratification Secondary objective Sepsis SOFA SOFA score subgroups suPAR survival survivor [DOI] 10.1038/s41598-021-96352-1 PMC 바로가기 [Article Type] Article
Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives안티 코로나 바이러스 및 면역 조절 페놀 화합물 : 기회 및 약물 치료 적 관점Review Published on 2021-08-232022-09-01 Journal: Biomolecules [Category] 진단, 치료제, [키워드] acute respiratory syndrome coronavirus antiviral drug antiviral drugs applicability cardiovascular caused chalcone Comorbidities COVID-19 COVID-19 patients diabetes disease dual dysregulated immune response dysregulated immune responses effective flavonoid high mortality rate immune response immune responses immunomodulatory activities kidney Kidney diseases MERS-CoV Middle East Respiratory Syndrome Virus modulation natural phenolic compound natural phenolic compounds natural products Novel coronavirus opportunity patients with comorbidity Perspective pharmacological Pharmacotherapeutic plants respiratory Respiratory disease SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe respiratory disease shown systemic inflammation therapeutic strategy viruses [DOI] 10.3390/biom11081254 PMC 바로가기 [Article Type] Review