A pragmatic randomized trial of home-based testing for COVID-19 in rural Native American and Latino communities: Protocol for the “Protecting our Communities” studyArticle Published on 2022-08-012022-10-05 Journal: Contemporary clinical trials [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] added American Arm ARMS benefit Care Community community health Community health worker Community trial conducted COVID-19 COVID-19 test COVID-19 testing economic barrier evaluate feasibility Health health worker Home-based testing implementation Implementing lab Laboratory Latino nasal swab Native Native American outcome participant Population populations Pragmatic Protecting Randomized Randomized controlled trial randomized trial receive reduce Research SARS-CoV-2 SARS-CoV-2. Support The United States Trial Two-arm Washington [DOI] 10.1016/j.cct.2022.106820 PMC 바로가기 [Article Type] Article
CLEVER assay: A visual and rapid RNA extraction-free detection of SARS-CoV-2 based on CRISPR-Cas integrated RT-LAMP technologyCLEVER 분석: CRISPR-Cas 통합 RT-LAMP 기술을 기반으로 하는 SARS-CoV-2의 시각적이고 신속한 RNA 추출 없는 검출Article Published on 2022-08-012022-09-11 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 clinical sensitivity clustered regularly interspaced short palindromic repeats coronavirus COVID-19 COVID-19 diagnosis COVID-19 outbreak COVID-19 pandemic CRISPR CRISPR-Ca CRISPR-Cas12 develop diagnose Diagnosis epidemiological equipment extraction-free method faster guide RNA hospital human body infected patients integration Internal control involved Isolation isothermal amplification lab LAMP lateral flow lateral flow readout. limit logistics Loop-mediated isothermal amplification major defect management nasopharyngeal offer Oropharyngeal overcome Palindromic point-of-care POP7 Region Repeat reverse transcription RNA RNA extraction RNA isolation RNase P RT-LAMP SARS-CoV-2 SARS-CoV-2 detection severe acute respiratory syndrome Coronavirus Significance specificity stick the patient urgency Visual with COVID-19 [DOI] 10.1111/jam.15571 PMC 바로가기 [Article Type] Article
A Method for Variant Agnostic Detection of SARS-CoV-2, Rapid Monitoring of Circulating Variants, and Early Detection of Emergent Variants Such as OmicronSARS-CoV-2의 변이 불가지론적 검출, 순환 변이체의 신속한 모니터링 및 오미크론과 같은 새로운 변이체의 조기 검출을 위한 방법Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accelerate approach concerning COVID-19 Delta detect detection diagnostic test diagnostic tests effective Efficacy Genotype genotyping geographical distribution Health Organization healthcare in vitro in vitro diagnostics INDEL indels lab less Lineage marker monitoring mutations Next-generation sequencing NGS omicron polymorphism positive sample Prevalence prevalent public health quantity question raised Rapid reducing Reporting resources Responding retrospective reverse transcription PCR RT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Sequencing significantly single-nucleotide SNPs Specific Strains transmission pattern transmission patterns utility Vaccines variant variants variants. was determined WHO World Health Organization [DOI] 10.1128/jcm.00342-22 PMC 바로가기 [Article Type] Article
COVID-19 infection among vaccinated and unvaccinated: Does it make any difference?Observational Study Published on 2022-07-152022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] Admission Care Characteristics Cohort comorbid conditions Complication Computed tomography conducted COVID-19 infection COVID-19 patient Critical Critical care D-dimer levels death demographics determine develop discharge effective ferritin hospitalized patients immunization individual Infection invasive ventilation lab LDH LOS median medical records mortality rate NIV non-invasive ventilation outcome Patient patients Preliminary data presenting Primary outcome Probability procalcitonin profiles proportion prospective observational cohort recruited reduction in required secondary outcome serum severity significantly higher significantly increased Support the patient university vaccinate vaccination with COVID-19 [DOI] 10.1371/journal.pone.0270485 PMC 바로가기 [Article Type] Observational Study
Explainable artificial intelligence-based edge fuzzy images for COVID-19 detection and identificationResearch article Published on 2022-07-012022-10-05 Journal: Applied Soft Computing [Category] 진단, 치료기술, [키워드] Accuracy AUC Chest radiography chose clinician COVID-19 COVID-19 disease COVID-19 pandemic Critical definitive diagnosis detect effort Factor gold standard Health infected patient instance instances Intern of Things Internet lab learning Multi-input convolutional network network polymerase chain Precision predict Probability recall required Research screening method screening methods Soft computing torso transfer with COVID-19 X-ray XAI [DOI] 10.1016/j.asoc.2022.108966 [Article Type] Research article
Hyperhemolysis in a patient with sickle cell disease and recent SARS-CoV-2 infection, with complex auto- and alloantibody work-up, successfully treated with tocilizumab복합 자가항체 및 동종항체 검사가 포함된 겸상적혈구병 및 최근 SARS-CoV-2 감염 환자의 과용혈, 토실리주맙으로 성공적으로 치료Case Reports Published on 2022-07-012022-09-12 Journal: Transfusion [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] AIHA/drug-induced IHA antibody appear approved auto autoantibody Blood Cell characterized Chest complex concerning COVID-19 discharged disease Donor Evidence hemoglobin Hemolysis hospital Hospitalization immunohematology (RBC serology, blood groups) incompatible Inflammation lab Patient patients RBC RBCs Red cell returned SARS-COV-2 infection SCD serology single dose Symptom syndrome Tocilizumab transfused transfusion complications-non-infectious. treated Treatment treatment for COVID-19 warm [DOI] 10.1111/trf.16932 PMC 바로가기 [Article Type] Case Reports
Computational investigation of benzalacetophenone derivatives against SARS-CoV-2 as potential multi-target bioactive compoundsSARS-CoV-2에 대한 벤잘아세토페논 유도체의 잠재적 다중 표적 생리활성 화합물의 전산 조사Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro 3CL(pro) addition Anti-SARS-CoV-2 Activity Antiviral antiviral activities Antiviral agents AutoDock Benzalacetophenones binding affinity binding energy binding free energy biological processes Candidates cellular components Compound COVID-19 derivative develop Diseases domain down-regulated enrichment analysis evaluated FIVE flavonoids free energy highest highest binding affinity identify Immune boost immune system Immunity immunostimulant Interaction lab modulated modulation molecular molecular docking molecular dynamics Molecular dynamics simulation molecular functions Molecular mechanics multiple pathway multiple pathways network network pharmacology nine non-infectious Papain Papain-like protease pathway Pathways Patient pharmacological PL(pro) precursor precursors protease Protein recorded reflected regulated retrieved SARS-CoV-2 scored screened Simulation spike Spike protein spike protein. surface area target upregulated was performed [DOI] 10.1016/j.compbiomed.2022.105668 PMC 바로가기 [Article Type] Article
The value of contact tracing and isolation in mitigation of COVID-19 epidemic: findings from outbreak investigation of COVID-19 onboard Nile Cruise Ship, Egypt, March 2020COVID-19 전염병 완화를 위한 접촉 추적 및 격리의 가치: 2020년 3월 이집트 나일 크루즈 선상에서의 COVID-19 발병 조사 결과Article Published on 2022-07-012022-09-11 Journal: BMJ Global Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] age Asymptomatic Cairo case finding Case isolation category close contact Contact Contact tracing containment measures COVID-19 COVID-19 case COVID-19 patient COVID-19 patients COVID-19 transmission Cruise ship defined detect effective Egyptians Epidemiology female Health authority hotel index case index cases individual infection control investigation Isolation lab male measure Nile outbreak pandemic PCR performed positive public health public health. questionnaire reducing secondary cases significantly higher tested triggered WHO [DOI] 10.1136/bmjgh-2022-008681 PMC 바로가기 [Article Type] Article
Tracheal Aspirate and Bronchoalveolar Lavage as Potential Specimen Types for COVID-19 Testing Using the Cepheid Xpert Xpress SARS-CoV-2/Flu/RSVCepheid Xpert Xpress SARS-CoV-2/Flu/RSV를 사용한 COVID-19 검사를 위한 잠재적 표본 유형으로서의 기관 흡인 및 기관지폐포 세척Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] addition anticipated approved aspirate BAL Bronchoalveolar lavage bronchoalveolar lavage sample bronchoalveolar lavage samples Cepheid community transmission COVID-19 criteria Cycle threshold values Diagnosis diagnostic test evaluated Evidence help hospital implication Influenza influenza A influenza B lab lavage Lower respiratory tract lower respiratory tract specimen management multiplex multiplex. overcome Patient PCR test performance platform point of care positive Potential Precision provide Rapid diagnostic test reproducibility respiratory respiratory specimen respiratory syncytial virus SARS-CoV-2 SARS-CoV-2 detection specimen specimens target tested Testing the SARS-CoV-2 tracheal Type upper respiratory tract Xpert Xpress SARS-CoV-2 assay [DOI] 10.1128/spectrum.00399-22 PMC 바로가기 [Article Type] Article
The Cyclophilin-Dependent Calcineurin Inhibitor Voclosporin Inhibits SARS-CoV-2 Replication in Cell Culture사이클로필린 의존성 칼시뉴린 억제제 보클로스포린은 세포 배양에서 SARS-CoV-2 복제를 억제합니다Article Published on 2022-06-242022-09-11 Journal: Transplant International [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity Antiviral assays assays benefit binding calcineurin calcineurin inhibitors can not clinical evaluation CNI Combination Comorbidity Compound compounds Concentration coronavirus Coronaviruses Course COVID-19 cyclophilin cyclosporin cyclosporin A EC50 value EC50 values evaluated experiments False-positive results human Calu-3 cell human Calu-3 cells Immunosuppressant immunosuppressants Immunosuppression immunosuppressive increased risk Infection inhibitor Interference kidney kidney transplant recipients Kidney transplantation lab progeny protocol recipient reduced reducing regimen reported RNA viruses SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus tacrolimus voclosporin voclosporin. with COVID-19 [DOI] 10.3389/ti.2022.10369 PMC 바로가기 [Article Type] Article