Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in miceSARS-CoV-2 복제를 감소시키고 마우스에서 염증 유발 폐 손상을 완화하기 위한 항히스타민제와 렘데시비르의 조합 이점Article Published on 2022-05-182022-09-11 Journal: Zoological research [Category] COVID19(2023년), SARS, 치료제, [키워드] alveolar antagonist Anti-inflammatory Anti-inflammatory therapy Antihistamine Antihistamines Antiviral antiviral drug antiviral therapy benefit caused Chinese clinical benefits Combination Combinational therapy COVID-19 COVID-19 treatment degranulation demonstrated Endothelial cell English epithelial feasible Histamine histamine receptor hyperinflammation Immune-mediated in vivo Inflammation inflammation-induced lung injury inflammatory disease initiate Injury lAbel loratadine Lung injury lung lesion lung lesions mast cell Mast cells MCs mediator mice off-label off-label use predicted Prevent prevented receptor reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike protein Spike protein suggested suppress Treatment viral replication [DOI] 10.24272/j.issn.2095-8137.2021.469 PMC 바로가기 [Article Type] Article
An excitation wavelength-optimized, stable SERS biosensing nanoplatform for analyzing adenoviral and AstraZeneca COVID-19 vaccination efficacy status using tear samples of vaccinated individuals백신 접종자의 눈물 샘플을 사용하여 아데노바이러스 및 AstraZeneca COVID-19 예방 접종 효능 상태를 분석하기 위한 여기 파장 최적화된 안정적인 SERS 바이오 센싱 나노 플랫폼Article Published on 2022-05-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Adenovirus antibody AstraZeneca AZD1222 ChAdOx1 COVID-19 vaccination Efficacy Epidemic Epidemic keratoconjunctivitis fluids Hypothesis identify Immunoglobulin Immunoglobulin G Keratoconjunctivitis lAbel Label-free SERS biosensing platform limit of detection marker Near- and far-field properties Non-invasive Oxford-AstraZeneca Oxford-AstraZeneca vaccine Patient platform product receive reproducibility robust robustness scattering stability Stability and robustness Standard deviation Tear Tear fluids. tears the vaccine vaccinated individual vaccinated individuals vaccination Vaccination Status Vaccine [DOI] 10.1016/j.bios.2022.114079 PMC 바로가기 [Article Type] Article
Drugs used during the COVID-19 first wave in Vitoria-Gasteiz (Spain) and their presence in the environmentVitoria-Gasteiz(스페인)의 COVID-19 1차 물결 동안 사용된 약물과 환경에서의 존재Article Published on 2022-05-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Administered affected Analysis Antiviral antiviral activity Azithromycin benefit cisatracurium city Concentration country COVID 19 COVID-19 COVID-19 pandemic defined detrimental effects dose drug Drug pollution first positive First wave healthcare professionals hospital Hydroxychloroquine ICUs intensive care unit intensive care units lAbel LC-q-Orbitrap Lopinavir LOPINAVIR AND RITONAVIR Lopinavir/ritonavir medium one health pandemic Patient patients pharmacoepidemiology positive potential risk proportion Quotient risk Ritonavir SARS-CoV2 selected drug selected drugs situation Spain target Target analysis. Treatment urgency Vitoria were used [DOI] 10.1016/j.scitotenv.2022.153122 PMC 바로가기 [Article Type] Article
Comprehensive Treatment of Hematological Patients with SARS-CoV-2 Infection Including Anti-SARS-CoV-2 Monoclonal Antibodies: A Single-Center Experience Case SeriesAnti-SARS-CoV-2 단클론항체를 포함한 SARS-CoV-2 감염 혈액병 환자의 종합 치료: 단일 센터 경험 사례 시리즈Article Published on 2022-03-262022-09-11 Journal: Current Oncology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Analysis antibody Antibody therapy B.1.1.529 B.1.617.2 bamlanivimab benefit best Cancer case sery Casirivimab clearance clinical clinical effectiveness Combination Comprehensive coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient delta variant Diagnosis Effectiveness exacerbated experience FIVE hematologic hematologic malignancies Hematologic malignancy Hematological malignancies high risk Hospitalization Imdevimab Including knowledge lAbel less mAbs monoclonal antibodies monoclonal antibody Mortality off-label omicron Omicron variant oxygen oxygen supplementation Patient Potential receiving reduce reduced reduction in respiratory retrospective risk SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2-infected patient Sery severe acute respiratory syndrome Coronavirus shown Sotrovimab suggested Tolerability Treatment variant [DOI] 10.3390/curroncol29040188 PMC 바로가기 [Article Type] Article
Mutation profile of SARS-CoV-2 genome in a sample from the first year of the pandemic in Colombia콜롬비아에서 전염병이 발생한 첫해 샘플에서 SARS-CoV-2 게놈의 돌연변이 프로필Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus base pairs Beta CDC circulating clade collected concern coronavirus correlation COVID-19 D614G diagnostic diagnostic test disease severity E484K Effectiveness Evidence followed by Gamma genetic change genetic information Genetic variation genomic genomic variant GISAID Health Organization High-throughput nucleotide sequencing host immunity interest L18F lAbel Lineage Missense MOST Mutation next generation sequencing NGS non-structural proteins nucleotide ORF1ab gene pandemic predominant recent regions S gene SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants sequenced South America structural protein structural proteins Surveillance synonymous the SARS-CoV-2 genome the WHO Vaccines variants virus VoC WHO Whole genome sequencing World Health Organization [DOI] 10.1016/j.meegid.2021.105192 PMC 바로가기 [Article Type] Article
SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injurySARS-CoV-2 유발 비만 세포 급속 탈과립은 폐포 상피 염증 및 폐 손상을 유발합니다Article Published on 2021-12-172022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료제, [키워드] ACE-2 ACE2 acute lung injury administration alveolar alveolar epithelial cells binding Cell COVID-19 severity COVID-19 treatments degranulation disrupt epithelial epithelial cells humanized hyper-inflammation hypercytokinemia identifying immune immunomodulator immunomodulators induce Infectious diseases Inflammation initiate initiated Injury lAbel Lung inflammation Lung injury mast cell Mast cells MCs mechanism mediators mice Microbiology mucosa off-label off-label use prevented pro-inflammatory factor pro-inflammatory factors RBD binding reduce regulate rhesus macaques SARS-CoV-2 SARS-COV-2 infection signaling pathway tight junction tight junctions Trigger triggers [DOI] 10.1038/s41392-021-00849-0 PMC 바로가기 [Article Type] Article
An Open Label, Adaptive, Phase 1 Trial of High‐Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS‐CoV‐2Article Published on 2021-11-132022-10-31 Journal: Clinical Pharmacology and Therapeutics [Category] COVID-19, [키워드] adaptive Administered adverse events antiparasitic Antiviral approved approved drug Bilirubin candidate clinically Concentration COVID‐19 diarrhea dose doses dosing interval drug drug discontinuation effective intervention enrolled FDA first dose food healthy immunomodulatory in vitro in vivo indicated initiated lAbel nitazoxanide occurred open label oral outcome participant Participants Patient pharmacokinetic Phase 1 Phase I public health crisis repurposing resolved Safe SARS‐CoV‐2 severe coronavirus disease Stool Tolerability Treatment Trial trial platform Urine [DOI] 10.1002/cpt.2463 PMC 바로가기 [Article Type] Article
A cost of illness study of COVID-19 patients and retrospective modelling of potential cost savings when administering remdesivir during the pandemic “first wave” in a German tertiary care hospitalCOVID-19 환자의 질병 비용 연구 및 독일 3차 치료 병원에서 전염병 "1차 유행" 동안 렘데시비르를 투여할 때 잠재적 비용 절감에 대한 후향적 모델링Original Paper Published on 2021-08-182022-09-10 Journal: Infection [Category] COVID19(2023년), SARS, 치료기술, [키워드] acquisition administration Analysis Care category China Clinical severity conducted coronavirus disease COVID-19 COVID-19 patient Diagnosis disease DRG eligible European Medicines Agency Germany healthcare Healthcare system Healthcare systems heterogeneous hospital Inpatient Inpatients invasive ventilation lAbel median Novel coronavirus novel coronavirus disease Ordinal Scale oxygen pandemic Patient Perspective Potential Real-life data reduced Remdesivir resource resources Result retrospective SARS-CoV-2 shown Spread supplemental oxygen treated Treatment Treatment costs university Variability variety were assessed [DOI] 10.1007/s15010-021-01685-8 PMC 바로가기 [Article Type] Original Paper
SARS-CoV-2 Vaccination in IBD: Past Lessons, Current Evidence, and Future ChallengesIBD의 SARS-CoV-2 예방 접종: 과거 교훈, 현재 증거 및 미래 과제Review Published on 2021-08-022022-09-11 Journal: Journal of Crohn's & colitis [Category] SARS, 변종, [키워드] cellular challenge Community complications of COVID-19 COVID-19 current Effectiveness Evidence Future high risk humoral IBD identify immune response immune responses immunogenicity immunosuppressive immunosuppressive therapy in some individual Infection Inflammatory bowel disease inflammatory bowel diseases knowledge lAbel off-label pandemic Patient patients SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines therapy translated trials vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines variants were excluded [DOI] 10.1093/ecco-jcc/jjab046 PMC 바로가기 [Article Type] Review
Analysis of DNA Sequence Classification Using CNN and Hybrid ModelsCNN 및 하이브리드 모델을 사용한 DNA 서열 분류 분석Research Article Published on 2021-07-152022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 치료기술, [키워드] automatically classification CNN Complete COVID-19 Data analysis deep learning DNA DNA sequence drug design evaluated experimental results explicit feature Features help high accuracy hybrid identification input issue K -mer lAbel lack Metrics Model offer outbreak selection process sequence sequences virus viruses [DOI] 10.1155/2021/1835056 PMC 바로가기 [Article Type] Research Article