The evaluation of novel oral vaccines based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum to neutralize SARS-CoV-2 variants alpha and delta자가 증폭 RNA 지질 나반파 (Sarna LNP), Sarna 형질 감염된 락토 바실러스 발바닥 LNP 및 Sarna 형질 감염된 Lactobacillus plantarum에 기초한 신규 구강 백신의 평가를 위해 SARS-COV-2 변이체 알파 및 델타를 중화시킨다.Article Published on 2021-10-292022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Alpha antibody BALB/c mice biodistribution cells Concentration coronavirus evaluate Express followed by highest IgA IgG IgG1 IgG2a immunology intestine lactobacillus large intestine liver mice mRNA neutralize oral administration Oral vaccine oral vaccines protein levels recovered COVID-19 patient Recovered COVID-19 patients respiratory responses RNA RNA vaccines S-protein saRNA SARS-CoV-2 variant secreted severe acute respiratory syndrome Coronavirus small intestine study groups Vaccines variant Viral viral neutralization was done [DOI] 10.1038/s41598-021-00830-5 PMC 바로가기 [Article Type] Article
Potential Adjuvant Therapeutic Effect of Lactobacillus plantarum Probio-88 Postbiotics against SARS-COV-2Article Published on 2021-09-242022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Lactobacillus plantarum adjuvant antiviral activity approach association binding binding affinity Cell conducted coronavirus COVID-19 COVID-19 pandemic develop drug Effect Efficacy effort ERK evaluated Helicase IFN-α IFN-β IL-6 immune regulation in silico in vitro indicated infected cells Infection Inflammatory Inflammatory marker inhibited lactobacillus Microbiome molecular docking pathogen plantaricin postbiotics Potential Prevent reactive oxygen specy reduction in Replication ROS SARS-CoV-2 severity significantly Spread tested Therapeutic approach treated Vaccine variants viral replication virus while [DOI] 10.3390/vaccines9101067 PMC 바로가기 [Article Type] Article
Narrowing down the number of potential plant-based probiotic candidates by successive in vitro, technological and in vivo assays연속적인 인 비트로, 기술적 및 인 비보 시험을 통해 잠재적인 식물성 프로바이오틱 후보의 수를 좁히기Article Published on 2021-08-302024-08-21 Journal: Benef Microbes [Category] 살모넬라증, [키워드] fermented food Lactic acid bacteria Lactiplantibacillus plant-based lactobacillus Salmonella
Gut Dysbiosis during COVID-19 and Potential Effect of ProbioticsReview Published on 2021-07-282022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Bifidobacteria ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Antiviral effect association bifidobacteria binding cause cell entry characterized clinical trial Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 severity dietary supplement disease Dysbiosis Effect effective Efficacy Evidence evidenced exhibiting expressed family Coronaviridae fecal gastrointestinal involvement Gut gut microbiome Health homeostasis IMPROVE infect Inflammation intestinal lactobacillus lung oral pathogen Potential Probiotics receptor RNA virus SARS-CoV-2 SARS-COV-2 infection Spike protein target therapeutic therapy tissues transmembrane protein Transmission treating COVID-19 treating COVID-19 patient [DOI] 10.3390/microorganisms9081605 PMC 바로가기 [Article Type] Review
Genome Features and In Vitro Activity against Influenza A and SARS-CoV-2 Viruses of Six Probiotic StrainsResearch Article Published on 2021-06-182022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] activity Antibiotic resistance Antibiotics antiviral activity Bacterial Bifidobacterium Bifidobacterium longum biochemical caused cells Complete demonstrated determinant determine disease explained Genome H1N1 Human Illumina Inc infect influenza A influenza A virus Influenza virus intestine lactobacillus MDCK cells MiSeq molecular nonpathogenic plasmids platform Probiotic probiotic bacteria resistance respiratory virus Result Safe SARS-CoV-2 SARS-CoV-2 virus strain SARS-CoV-2 viruses strain Strains the SARS-CoV-2 virus was performed were used Whole genome sequencing [DOI] 10.1155/2021/6662027 PMC 바로가기 [Article Type] Research Article
Genome Features and In Vitro Activity against Influenza A and SARS-CoV-2 Viruses of Six Probiotic StrainsResearch Article Published on 2021-06-182022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, Fulltext, MERS, SARS, 신종인플루엔자, [키워드] activity Antibiotic resistance Antibiotics antiviral activity Bacterial Bifidobacterium Bifidobacterium longum biochemical caused cells Complete demonstrated determinant determine disease explained Genome H1N1 Human Illumina Inc infect influenza A influenza A virus Influenza virus intestine lactobacillus MDCK cells MiSeq molecular nonpathogenic plasmids platform Probiotic probiotic bacteria resistance respiratory virus Result Safe SARS-CoV-2 SARS-CoV-2 virus strain SARS-CoV-2 viruses strain Strains the SARS-CoV-2 virus was performed were used Whole genome sequencing [DOI] 10.1155/2021/6662027 PMC 바로가기 [Article Type] Research Article
Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virusArticle Published on 2021-03-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] 16S rRNA activity addition Administered alanine aminotransferase alkaline phosphatase alleviate Anti-inflammatory antimicrobial agent antioxidant applied Aspartate aminotransferase Blood caecum Clostridium collected Concentration Culture determine diamine oxidase dismutase dosage Drug discovery ENhance Enterobacteriaceae Enterococcus epidemic diarrhea fatty Heat shock hydrogen peroxide Infection infectious dose inoculated interleukin-6 intestinal intestinal injury intestine lactobacillus Microbiology Molecular biology morbidity mRNA level myeloperoxidase Neutrophils nuclear PEDV peroxidase plasma plasma concentration Protein protein concentration puerarin reduced reported Result serum TCID tissue Trial tumor necrosis factor-α virus White blood cell [DOI] 10.1038/s41598-021-85880-5 PMC 바로가기 [Article Type] Article
Lactobacillus Regulates Caenorhabditis elegans Cell Signaling to Combat Salmonella Infection락토바실러스는 살모넬라 감염에 맞서 카에노르하브디티스 엘레간스 세포 신호를 조절한다.Original Research Published on 2021-03-082024-07-29 Journal: Frontiers in immunology [Category] 살모넬라증, [키워드] antimicrobial peptides Caenorhabditis elegans Cell signaling defense molecules lactobacillus Salmonella [DOI] 10.3389/fimmu.2021.653205 PMC 바로가기 [Article Type] Original Research
Probiotics: A potential immunomodulator in COVID-19 infection managementReview Published on 2021-02-132023-06-14 Journal: Nutrition Research (New York, N.y.) [Category] MERS, SARS, [키워드] ACE2, angiotensin-converting enzyme 2 COVID-19 COVID-19, coronavirus disease CRP, C-reactive protein GCSF, Granulocyte colony-stimulating factor IFN-γ, Interferon-gamma IFV, influenza A virus IL, interleukin Influenza virus lactobacillus MERS-CoV, Middle East respiratory syndrome coronavirus NK, natural killer OAS, Oligoadenylate synthetase Probiotics respiratory viral infection RVI, Respiratory virus infections SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Th1/2, T-helper cells type 1 and 2 TNF, Tumor Necrosis Factor WHO, World Health Organization [DOI] 10.1016/j.nutres.2020.12.014 PMC 바로가기 [Article Type] Review
Isolation and Evaluation of Probiotic Potential of Lactic Acid Strains From Healthy Equines for Potential Use in Salmonella InfectionArticle Published on 2021-01-312024-09-07 Journal: J Equine Vet Sci [Category] 살모넬라증, [키워드] equine lactobacillus Probiotic potential Safety Salmonella PMC 바로가기