lectin – Page 2 – Communicable Diseases Research

Engineering recombinantly expressed lectin-based antiviral agents

Article

Published on 2022-09-232022-11-15
Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료제,

Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concern

Article

Published on 2022-08-302022-11-15
Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료제,

[키워드] addition Antiviral antiviral activity assays Beta binding block Cell cell cultures cell types cell-cell fusion cells circulating Coronaviruses Deletion Delta demonstrated fusion inhibitor Gamma inhibit inhibited inhibitor interface investigated lectin lung epithelial membrane fusion monomeric mutant N-acetylglucosamine (GlcNAc) N-glycosylation omicron Prevent Protein pseudotyped SARS-CoV-2 remained Replication replication of SARS-CoV-2 S2 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant Spike protein SPR subsequent surface plasmon resonance tested the spike protein UDA Urtica variant variants of concern variants of SARS-CoV-2 Vero E6 cell viral replication viral spike protein virus entry viruses Wuhan-Hu-1
[DOI] 10.3389/fcimb.2022.989534 PMC 바로가기

Germline rare variants of lectin pathway genes predispose to asymptomatic SARS-CoV-2 infection in elderly individuals

렉틴 경로 유전자의 생식선 희귀 변이체는 노인에서 무증상 SARS-CoV-2 감염을 일으키기 쉽습니다.

Article

Published on 2022-08-012022-09-11
Journal: Genetics in medicine : official journal of the Ame [Category] COVID19(2023년), SARS, 변종,

[키워드] allelic variant allelic variants Asymptomatic Asymptomatic COVID-19 asymptomatic individual Asymptomatic individuals asymptomatic subject Cohort COLEC10 COLEC11 Collapsing complement complement system COVID-19 decreased activity decreased expression enrichment ES European Evidence exome sequencing data Genes Genetic genetic data Genome Aggregation Database germline Hospitalized hospitalized patient Hyperactivation individual individuals investigated lectin lectin pathway lung tissue MASP1 outcome performed phenotype predicted PROTECT prothrombin rare variant replicated SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease susceptible variant with COVID-19
[DOI] 10.1016/j.gim.2022.04.007 PMC 바로가기 [Article Type] Article

Removal of clinically relevant SARS-CoV-2 variants by an affinity resin containing Galanthus nivalis agglutinin

Galanthus nivalis agglutinin을 함유한 친화성 수지에 의한 임상적으로 관련된 SARS-CoV-2 변이체 제거

Article

Published on 2022-07-282022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종,

[키워드] Adult patients affecting bind binding characterized clinically Concentration control sample COVID-19 COVID-19 infection decrease Efficacy Efficiency exceeded extrapolation Galanthus in viral indicated infectiousness lectin limitation mannose medium monoclonal antibodies Mutation mutations pandemic Patient removal resistance SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Seven Severe COVID-19 Infection severe disease Spike protein Structure the SARS-CoV-2 virus the spike protein therapy Treatment vaccination Vaccine variant variants viral envelope Viral load viral loads viral titer virulence
[DOI] 10.1371/journal.pone.0272377 PMC 바로가기 [Article Type] Article

A Highly Potent SARS-CoV-2 Blocking Lectin Protein

렉틴 단백질을 차단하는 매우 강력한 SARS-CoV-2

Article

Published on 2022-07-082022-09-11
Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected blocking cell line coronavirus coronavirus disease Coronavirus disease-19 COVID-19 death Delta demonstrated drug effective entry of SARS-CoV-2 FIVE Frequency globe Hospitalization ICU admissions IFNAR Infection lectin mouse model Mutation New coronavirus omicron Omicron variants pandemic Please add keywords. potent preventing the transmission Prophylactic Protein SARS-CoV-2 secure severe acute respiratory syndrome Coronavirus social contact Spike protein spread of COVID-19 the spike protein variants Vero E6 Wuhan strain
[DOI] 10.1021/acsinfecdis.2c00006 PMC 바로가기 [Article Type] Article

Sensing the interactions between carbohydrate-binding agents and N-linked glycans of SARS-CoV-2 spike glycoprotein using molecular docking and simulation studies

Article

Published on 2022-06-012023-07-06
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS,

[키워드] lectin molecular docking and MD simulation Pradimicin-A SARS-CoV-2 spike glycoprotein
[DOI] 10.1080/07391102.2020.1851303 PMC 바로가기

The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3

SARS-CoV-2 스파이크 단백질의 S1 서브유닛은 인간 단핵구를 활성화하여 COVID-19와 연결된 사이토카인을 생성합니다: 갈렉틴-3과의 관련성

Article

Published on 2022-03-222022-09-11
Journal: Frontiers in Immunology [Category] SARS, 변종,

[키워드] ACE2 activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS basophil basophils bind caused component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRS cytokine Cytokine release syndrome Cytokines dendritic dendritic cell disease dysregulated Efficacy epithelial cell epithelial cells Evidence facilitate feature fold galectin-3 Health human monocyte human monocytes immune cells Inflammation innate immune innate immune cell Innate immune cells innate immune response Innate immunity lectin Lung injury mechanism MERS Middle East Middle East respiratory syndrome monocyte Monocytes N-terminal domain novel vaccines NTD pandemic persistence pocket Produce Relevance reported respiratory respiratory distress Respiratory distress syndrome responsible S1 subunit S1-NTD S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus shown solid phase spike Spike protein stalk structural homology susceptible individuals syndrome synthesis the S1 subunit the SARS-CoV-2 the spike protein therapeutic interventions Therapeutics Vaccine variants virus while β-Coronaviruses
[DOI] 10.3389/fimmu.2022.831763 PMC 바로가기 [Article Type] Article

Complement Activation via the Lectin and Alternative Pathway in Patients With Severe COVID-19

중증 COVID-19 환자의 렉틴 및 대체 경로를 통한 보완 활성화

Immunology

Published on 2022-02-022022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] activate activated Activation Acute kidney injury acute respiratory syndrome addition Alternative pathway alveolar alveolar septa analyzed Autopsy both groups both lungs C1q C3c C5b-9 causes cerebral hemorrhage CFD characterized collateral tissue complement Complement activation complement deposition Control correlated correlation COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients Cytokines Defense deposit deposition deregulated died edema Factor followed by hyaline membrane hyaline membranes Immune cell immune cells immune system immunohistochemistry in both groups indicated Inflammatory response Injury investigated involved kidney kidneys lectin lectin pathway Local lung Lung injury Lungs MASP-2 membranes Mortality MPO myeloperoxidase neutrophil Neutrophils occurred Pathogens Patient patients with COVID-19 peritubular capillaries peritubular capillary positive Prevent pro-inflammatory cytokines Pulmonary embolism respiratory SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV-2 virus particle SARS-CoV-2 virus particles semi-quantitative Severe acute respiratory syndrome severe COVID-19 SIGN significantly significantly higher significantly more Spike protein subsequent thrombi tissue damage tissue injury Treatment with COVID-19 worsening
[DOI] 10.3389/fimmu.2022.835156 PMC 바로가기 [Article Type] Immunology

Persistently elevated complement alternative pathway biomarkers in COVID-19 correlate with hypoxemia and predict in-hospital mortality

COVID-19에서 지속적으로 상승된 보체 대체 경로 바이오마커는 저산소혈증과 상관관계가 있으며 병원 내 사망률을 예측합니다

Article

Published on 2022-02-012022-09-11
Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] Activation Alternative pathway analyzed Biomarker C-reactive protein C5a cause complement Complement activation coronavirus disease Coronavirus disease 2019 correlations COVID-19 COVID-19 patient elevated enzyme enzyme-linked immunosorbent assays Evidence Factor Factor B ferritin healthy control healthy controls Hypoxemia ICU ICU admission IL-6 Immunity in-hospital mortality independent predictor Inflammatory response Innate Innate immunity lectin Level Lung disease marker measure Mortality Multi-organ damage overactivation pathway Patient patient sera predict prospectively studied quantified reduction Respiratory function risk SC5b-9 sera Serum level severely ill COVID-19 patients severity significantly sustained the patient
[DOI] 10.1007/s00430-021-00725-2 PMC 바로가기 [Article Type] Article

Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses

Review

Published on 2022-01-202022-10-31
Journal: Cells [Category] COVID-19, SARS,

[키워드] N-glycosite O-glycosite antiviral drug beta-coronaviruses can be used classical complex complex N-glycans complex glycan complex glycans contribute Ebola virus enveloped virus GlcNAc glycan glycans glycoprotein gp120 herpes simplex virus high-mannose high-mannose glycan HIV host cell Human Cytomegalovirus Human immunodeficiency virus Influenza Influenza virus Interaction lectin Legume Man MERS-CoV occur Other plant Potential prefusion probe provide responsible SARS-CoV SARS-CoV-2 specific interaction specificity Spike protein Structure T/Tn-specific lectin Vicieae man-specific lectin virion virus viruses
[DOI] 10.3390/cells11030339 PMC 바로가기 [Article Type] Review