Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review항종양 및 항바이러스 잠재력을 갖지만 약물 유발 간 손상을 갖는 레플루노마이드 면역조절제: 포괄적인 검토Review Published on 2021-04-012022-09-11 Journal: International immunopharmacology [Category] SARS, 임상, 치료제, [키워드] affected Anti-inflammatory Antineoplastic Antiviral antiviral activity approved Arthritis Autoimmune benefit Bilirubin Biomarkers catalytic Cell cell growth cellular Combination Compound COVID-19 Cytokines de novo synthesis DHODH drug drug-induced Drug-induced liver injury enzyme event growth hepatic impairment hepatic injury Immunoglobulin immunological immunomodulator Immunosuppression inhibit inhibitors joint destruction leflunomide Leflunomide. liver liver enzyme liver enzymes Liver injury membrane mitochondrial nucleotide nucleotides off-label outcome Pathogenesis pathophysiology Patient Perspective pharmacological precautions proliferation Protective Protein pyrimidine reducing Regulatory Relapsing-Remitting Multiple Sclerosis reported required responsible Rheumatoid safety profile SARS CoV SARS CoV-2 serum Treatment Trial tyrosine with COVID-19 [DOI] 10.1016/j.intimp.2021.107398 PMC 바로가기 [Article Type] Review
A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical TrialControlled Trial Published on 2020-07-212023-06-15 Journal: Virologica Sinica [Category] MERS, SARS, [키워드] Coronavirus disease 2019 (COVID-19) DHODH inhibitors Inflammation leflunomide viral shedding time [DOI] 10.1007/s12250-020-00258-7 PMC 바로가기 [Article Type] Controlled Trial
Mitomycin, 5-fluorouracil, leflunomide, and mycophenolic acid directly promote hepatitis B virus replication and expression in vitroResearch Published on 2020-07-012023-08-29 Journal: Virology Journal [Category] E형 간염, [키워드] 5-Fluorouracil lamivudine leflunomide mycophenolic acid Reactivation of hepatitis B virus; Mitomycin [DOI] 10.1186/s12985-020-01339-5 PMC 바로가기 [Article Type] Research
A complex COVID-19 case with rheumatoid arthritis treated with tocilizumabCase Based Review Published on 2020-06-192022-10-31 Journal: Clinical Rheumatology [Category] COVID-19, SARS, [키워드] administration applied Aspergillus fumigatus close monitoring complex Coronavirus disease 2019 COVID-19 COVID-19 case CRS cytokine cytokine release storm disciplinary disease drug glucocorticoid Hydroxychloroquine IL-6 immune responses Immunity leflunomide long-term treatment opportunistic infection Patient patients patients with COVID-19 receptor signaling recurrence rheumatoid arthritis Secondary opportunistic infection Sequencing supplementary material Tocilizumab treated Treatment [DOI] 10.1007/s10067-020-05234-w PMC 바로가기 [Article Type] Case Based Review
Inhibition of porcine epidemic diarrhea virus (PEDV) replication by A77 1726 through targeting JAK and Src tyrosine kinasesArticle Published on 2020-06-182023-08-30 Journal: Virology [Category] E형 간염, [키워드] A77 1726 leflunomide p70 S6 kinase Porcine epidemic diarrhea virus Protein tyrosine kinases [DOI] 10.1016/j.virol.2020.06.009 PMC 바로가기 [Article Type] Article
Traditional Chinese medicine Biqi capsule compared with leflunomide in combination with methotrexate in patients with rheumatoid arthritis: a randomized controlled trialResearch Published on 2020-04-232024-09-02 Journal: Chinese Medicine [Category] 대상포진, [키워드] Biqi capsule clinical trial complementary therapy leflunomide metabolomics methotrexate rheumatoid arthritis Th2 inflammation [DOI] 10.1186/s13020-020-00319-9 PMC 바로가기 [Article Type] Research
Comparison of combined leflunomide and low-dose corticosteroid therapy with full-dose corticosteroid monotherapy for progressive IgA nephropathyClinical Research Paper Published on 2017-07-182024-09-02 Journal: Oncotarget [Category] 대상포진, [키워드] Corticosteroids IgA nephropathy leflunomide Proteinuria renal survival [DOI] 10.18632/oncotarget.16468 PMC 바로가기 [Article Type] Clinical Research Paper