Monitoring Anti-PEG Antibodies Level upon Repeated Lipid Nanoparticle-Based COVID-19 Vaccine Administration반복적인 지질 나노입자 기반 COVID-19 백신 투여 시 항-PEG 항체 수준 모니터링Article Published on 2022-08-092022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] adverse effects Analysis anti-PEG Ig anti-Spike Ig antibodies antibody booster Cohort COVID-19 COVID-19 vaccines dose Efficacy Evolution hypersensitivity reaction IgG IgM Immunity Level Lipid lipid-nanoparticle-mRNA (LNP-mRNA)-based vaccine. monitoring mRNA COVID-19 vaccines not affect Prevalence raised reducing repeated reported Result SARS-CoV-2 significant increase vaccinated individuals vaccination Vaccine [DOI] 10.3390/ijms23168838 PMC 바로가기 [Article Type] Article
Untargeted lipidomics reveals specific lipid profiles in COVID-19 patients with different severity from Campania region (Italy)비표적 지질학은 캄파니아 지역(이탈리아)과 중증도가 다른 COVID-19 환자의 특정 지질 프로필을 보여줍니다Article Published on 2022-08-052022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome alteration applied approaches blood sample Blood samples Campania cause Ceramides characterized clinical phenotype Cohort collected comparable contrary Control controls correspondence COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dataset decrease disease dysregulation highlight Hospital admission increase in Infection Italian Italy Lipid Lipidomics Liquid chromatography longitudinal population mass spectrometry Mild Modification MONITOR outcome Patient patients platform Potential biomarker predict profile respiratory reveal reversed Severe acute respiratory syndrome severe patients severity significantly subset TGs trajectory Trapped ion mobility UHPLC Untargeted. [DOI] 10.1016/j.jpba.2022.114827 PMC 바로가기 [Article Type] Article
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics Reviews Published on 2022-08-022022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] atherosclerotic atherosclerotic lesion benefit Cancer cancers cardiovascular disease cardiovascular diseases cardiovascular event cardiovascular system Cell cholesterol cholesterol homeostasis cholesteryl esters clinics Critical CVD diabetes disease Diseases Disturbed endothelial events Health inhibiting Intervention Lipid Low-Density Lipoprotein cholesterol maintaining mechanism molecular neurodegenerative nonalcoholic fatty liver obesity Osteoporosis pathway preclinical study Prevent PROTECT Regulation regulatory pathways Research shown target Transport Treatment virus infection [DOI] 10.1038/s41392-022-01125-5 [Article Type] Reviews
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article
Are lipid ratios and triglyceride-glucose index associated with critical care outcomes in COVID-19 patients?지질 비율과 트리글리세리드-글루코스 지수는 COVID-19 환자의 중환자 치료 결과와 관련이 있습니까?Article Published on 2022-08-012022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] adjusted age Analysis biochemical marker biochemical markers BMI carried cholesterol coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 mortality COVID-19 patient Critical care demonstrated evaluate Glucose HDL-C high-density insulin insulin resistance LDL-C Lipid lipoprotein Logistic regression analysis low-density Low-density lipoprotein Mortality multivariate multivariate logistic regression analysis outcome performed predictor Prognosis Regression regression models Research severe coronavirus disease Severe patient severe patients severity Sex significantly higher significantly lower statistically survivor Total cholesterol Triglyceride with COVID-19 [DOI] 10.1371/journal.pone.0272000 PMC 바로가기 [Article Type] Article
An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics Research Published on 2022-07-132022-10-05 Journal: Scientific Reports [Category] 바이오마커, 치료기술, 치료법, [키워드] alteration analysed analysis Analysis biofluid Blood changes in Cohort correlation COVID-19 COVID-19 infection dominant dyslipidaemia hallmark hospitalised immunostimulatory Lipid majority metabolite metabolites metabolomics negative controls participant Pathologies pathophysiological conditions Patient performed plasma positive profile provided Saliva salivary Sebum sensitivity Sensitivity and specificity serum specificity Triglyceride utilised [DOI] 10.1038/s41598-022-16123-4 [Article Type] Research
Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins25-하이드록시콜레스테롤의 항바이러스 분자 메커니즘 연구: 콜레스테롤 항상성 교란 및 단백질의 번역 후 변형Review Published on 2022-07-052022-09-11 Journal: European journal of pharmacology [Category] 치료제, [키워드] 25-Hydroxycholesterol activating Antiviral antiviral activity antiviral drug antiviral drugs Antiviral mechanism binding catalyzed cholesterol cholesterol homeostasis contribute coronavirus disease Coronavirus disease 2019 Efficiency efficient endoglycosidase endosomal pathway global public health glycan glycans glycosylation hydroxylase impair in vitro in vivo inhibiting Innate immunity Lipid Lipid raft liver Maturity mechanisms Modification molecular mechanism nucleic acid outbreak oxysterol oxysterol-binding protein pathway post-translational modification Post-translational modification. prenylation Previous studies previous study Protein reactive receptor reduce restrict second sensitivity shown Sterol Toxicity Viral protein Viral proteins virus [DOI] 10.1016/j.ejphar.2022.175033 PMC 바로가기 [Article Type] Review
Specific nutrition and metabolic characteristics of critically ill patients with persistent COVID-19Observational Study Published on 2022-07-012022-10-04 Journal: JPEN. Journal of parenteral and enteral nutrition [Category] 임상, [키워드] Admission C-reactive protein Characteristics characteristics of patient characterized cohorts collected constipation coronavirus disease COVID-19 COVID-19 patient Critical Critically ill patient defined demographic data diarrhea energy balance energy deficit Enteral faster gastrointestinal function Hospital stay hypophosphatemia ICU ICU protocol in both group Infection intestinal intubation less Lipid men Mortality mortality rate neuromuscular blockade non-respiratory organ nutrition obese obese patients Patient patients patients with COVID-19 patients without COVID-19 Prone position propofol proportion prospective observational study Protein reduced refeeding syndrome risk Screening Sedation severity scores significantly more SOFA score SOFA scores Specific syndrome target underfeeding. variables with COVID-19 [DOI] 10.1002/jpen.2334 PMC 바로가기 [Article Type] Observational Study
Electrostatic Map of the SARS-CoV-2 Virion Specifies Binding Sites of the Antiviral Cationic PhotosensitizerSARS-CoV-2 Virion의 정전기 지도는 항바이러스 양이온 광감작제의 결합 부위를 지정합니다Article Published on 2022-06-302022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] antibodies Antiviral Brownian dynamics coarse-grain model component computational method different materials distribution domain drugs E protein electrostatic electrostatic interactions Electrostatics Glutamate glutamate residue groups heterogeneous host cells Interaction Lipid lipids Map Numerous oxygen photosensitizer photosensitizer. phthalocyanine positive Positive Charge predict Protein Proteins Reactions reactive oxygen SARS-CoV-2 Site Structure target the SARS-CoV-2 understanding viral envelope viral membrane virion virus Zinc [DOI] 10.3390/ijms23137304 PMC 바로가기 [Article Type] Article
Equipment-free, unsupervised high intensity interval training elicits significant improvements in the physiological resilience of older adultsRandomized Controlled Trial Published on 2022-06-282022-10-05 Journal: BMC Geriatrics [Category] 임상, [키워드] addition Adults age approach baseline blood pressure body composition cardiometabolic cardiorespiratory cardiorespiratory fitness cholesterol circulating Cognitive impairment combating control group COVID-19 pandemic CRF diastolic Efficacy elicit exercise glucose tolerance groups HDL Health HIIT IMPROVE improvement independent independent risk factor intensity interval Intervention involved Laboratory lateralis Lipid mean difference Mortality offer Older parameter physiological Premature Primary outcome protocol randomised Registered Resilience supervision Supervision. threshold Tolerance vastus were assessed [DOI] 10.1186/s12877-022-03208-y PMC 바로가기 [Article Type] Randomized Controlled Trial