Plague vaccines: new developments in an ongoing search전염병 백신: 진행중인 검색의 새로운 개발Review Published on 2021-06-012022-09-12 Journal: Applied Microbiology and Biotechnology [Category] MERS, SARS, 진단, [키워드] candidate China clinically Critical death disease distribution DNA DNA vaccines drug Endemic etiological agent events food humoral increasingly live attenuated live-attenuated vaccine outbreak pandemic pathogen plague Progress protection Protein subunit. recent Region responsible SARS-CoV-2 infections strain subunit threat USA Vaccine vaccine candidate Vaccine development Yersinia pestis [DOI] 10.1007/s00253-021-11389-6 PMC 바로가기 [Article Type] Review
Correlation between polio immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study소아마비 예방접종 범위와 COVID-19의 전반적인 이환율 및 사망률 간의 상관관계: 역학 연구Research Article Published on 2021-03-022022-10-31 Journal: Environmental science and pollution research inter [Category] COVID-19, SARS, 폴리오, [키워드] Analysis analyzed conducted continuous variable correlated correlation Coverage COVID-19 death determine effort Endemic Epidemiological study estimate Evidence Frequency global health group immunization Kruskal-Wallis H test live-attenuated vaccine morbidity and mortality normally distributed Observatory P -value percentage polio Population positive correlation protective effect R software Repository significantly Spearman rank correlation spread of COVID-19 Standard deviation supplementary material Support the disease the vaccine vaccination Vaccine variables was used were used WHO World Health Organization’ [DOI] 10.1007/s11356-021-12861-6 PMC 바로가기 [Article Type] Research Article
Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine designArticle Published on 2020-12-202022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, MERS, [키워드] accessory protein cause cDNA Clinical signs clone coronavirus described diarrhea effective exhibited fluorescent full-length generate genetics GFP high mortality in viral in vitro in vivo Infection infectous clone Injury inoculated live-attenuated vaccine mutant virus Neonatal outbreak Pathogenesis PDCoV platform Porcine deltacoronavirus Protein provide reduction replacing replicate Replication resulting reveal start codon Vaccine Vaccine design viral titer virulence widespread wild-type [DOI] 10.1080/22221751.2019.1701391 PMC 바로가기 [Article Type] Article
Cold-Adapted Live Attenuated SARS-Cov-2 Vaccine Completely Protects Human ACE2 Transgenic Mice from SARS-Cov-2 InfectionArticle Published on 2020-10-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Administered Body weight loss Brain cellular immunity cold adaptation coronavirus death effective elicit form growth Human humans humoral IgA antibody Immunity intranasally K18-hACE2 mice kidneys Live attenuated vaccine live-attenuated vaccine Lungs mice mucosal nasal nasal turbinates neutralising antibody Safe SARS-CoV infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine single dose Spread susceptible tissues titre Vaccine Vero cells virus [DOI] 10.3390/vaccines8040584 PMC 바로가기 [Article Type] Article
The potential public health impact of Herpes Zoster vaccination in the 65 years of age cohort in Italy이탈리아의 65세 이상 집단에서 대상포진 백신의 잠재적인 공공 건강 영향Research Paper Published on 2020-09-242023-05-31 Journal: Human vaccines & immunotherapeutics [Category] Fulltext, 대상포진, 두창, 수두, 홍역, [키워드] Adjuvanted vaccine herpes zoster live-attenuated vaccine public health impact vaccination [DOI] 10.1080/21645515.2019.1657753 PMC 바로가기 [Article Type] Research Paper
Natural Polymorphisms Are Present in the Furin Cleavage Site of the SARS-CoV-2 Spike GlycoproteinSARS-CoV-2 스파이크 당단백질의 푸린 절단 부위에 천연 다형성이 존재합니다Genetics Published on 2020-07-172022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] Affect Candidates codon coronavirus COVID-19 DNA furin furin cleavage site host cells human cell human cells in vivo live-attenuated vaccine mutant Mutation mutations natural Non-synonymous premature stop codon present reduced required S protein SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 genome sequences Site spike spike glycoprotein strain the SARS-CoV-2 Transmissibility unique virus [DOI] 10.3389/fgene.2020.00783 PMC 바로가기 [Article Type] Genetics
Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence생백신 폴리오 백신의 설계로 virulence로의 재전환 방지Article Published on 2020-05-132024-08-25 Journal: Cell Host & Microbe [Category] 폴리오, [키워드] live-attenuated vaccine OPV2 Poliovirus poliovirus eradication Sabin 2p [DOI] 10.1016/j.chom.2020.04.003 PMC 바로가기 [Article Type] Article
Humanized Mice for Live-Attenuated Vaccine Research: From Unmet Potential to New PromisesReview Published on 2020-01-212024-09-02 Journal: Vaccines [Category] 대상포진, [키워드] animal model bacterial vaccine humanized mice immune response to vaccine immunogenicity live-attenuated vaccine Vaccine viral vaccine [DOI] 10.3390/vaccines8010036 PMC 바로가기 [Article Type] Review
Comparative Study of the Temperature Sensitive, Cold Adapted and Attenuated Mutations Present in the Master Donor Viruses of the Two Commercial Human Live Attenuated Influenza VaccinesArticle Published on 2019-10-102023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] Influenza live-attenuated vaccine Vaccine [DOI] 10.3390/v11100928 PMC 바로가기 [Article Type] Article
Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in EgyptResearch Article Published on 2019-02-112022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] analyses avirulent bronchitis cause chick circulating circumvent clinical disease Clinical sign comparable Complete develop development disease Express expressing growth IBV immunofluorescence in vitro Infectious Bronchitis Virus Lineage live-attenuated vaccine Middle East mutate newcastle disease virus parental prevalent provided recombine reduced reduction in resulting S glycoprotein S protein S protein expression significantly Single-dose SPF strain supplementary material tracheal vaccination Vaccine vaccine candidate variant viral shedding virulent virus viruses were expressed white wild type [DOI] 10.1186/s13567-019-0631-5 PMC 바로가기 [Article Type] Research Article