Immunogenicity and safety of SpikoGen®, an adjuvanted recombinant SARS-CoV-2 spike protein vaccine as a homologous and heterologous booster vaccination: A randomized placebo-controlled trialArticle Published on 2022-11-012022-11-15 Journal: Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% confidence interval Administered adverse event approved assessment booster booster dose booster vaccination clinical trials Course COVID-19 COVID-19 vaccination COVID-19 vaccine cross-neutralization cross-neutralization. Day double-blind Effect fatigue Heterologous homologous humoral immunogenic immunogenicity incidence injection site pain Local Neutralizing antibodies neutralizing antibody outcome participant Participants Placebo placebo-controlled primary immunogenicity Randomized randomized placebo-controlled trial Recombinant spike protein reported robust Safe Safety safety profile saline placebo SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants Serious Adverse Event Serious Adverse Events Seroconversion seroconversion rate shown SpikoGen subunit the placebo group Trial Vaccine was performed [DOI] 10.1111/imm.13540 PMC 바로가기
Epidemiological and clinical features of SARS-CoV-2 infection in children during the outbreak of Omicron variant in Shanghai, March 7-31, 2022Article Published on 2022-11-012022-11-16 Journal: Influenza and Other Respiratory Viruses [Category] SARS, 변종, [키워드] 95% confidence interval Asymptomatic calculated children children. clinical Clinical characteristics clinical feature collected Community confirmed cases cough COVID-19 COVID-19 case COVID-19 vaccination COVID-19 vaccine dissemination dose early stage eligible epidemiological febrile disease Fever hospital Infection interquartile range leukopenia Local median median interval offer omicron Omicron SARS-CoV-2 variant outbreak pediatric Pediatric case reduced Relative risk risk RRs SARS-CoV-2 SARS-COV-2 infection Seven Shanghai symptomatic case symptomatic infection Transmission model vaccination Vaccines variant [DOI] 10.1111/irv.13044 PMC 바로가기
Molecular interactions and inhibition of the SARS-CoV-2 main protease by a thiadiazolidinone derivativeArticle Published on 2022-11-012022-11-15 Journal: Proteins [Category] COVID19(2023년), SARS, 치료제, [키워드] comparable conformational docking enzyme inhibitor Interaction involved Local main protease molecular molecular dynamics Molecular dynamics simulation molecular interaction Pro probe protease protocol SARS-CoV-2 the SARS-CoV-2 thiadiazolidinone. viral life cycle [DOI] 10.1002/prot.26385 PMC 바로가기
Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activationArticle Published on 2022-11-012022-11-15 Journal: Veterinary microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] abrogated activated activating Activation acute respiratory syndrome Alpha antiviral immunity AP-1 binding C-terminal domain caused chemokine coronavirus coronavirus disease COVID-19 Cytokine release syndrome deleting demonstrated dependent on domain E E protein expression facilitate help IL-6 IL-8 induce Infection Inflammation inhibitor interleukin-6 IκBα life-threatening Local molecular mechanism motif NF-κB NF-κB pathway nuclear nuclear translocation p65 Pathogenesis PDCoV. Phosphorylation Proinflammatory cytokine promoter protein phosphorylation resulting SARS-CoV-2 Severe case upregulated [DOI] 10.1016/j.vetmic.2022.109553 PMC 바로가기
CovidConvLSTM: A fuzzy ensemble model for COVID-19 detection from chest X-raysResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy activity affected applied chest X-ray Chest X-ray images CNN comparable ConvLSTM COVID-19 datasets deep learning ENhance experiments feature Features Fuzzy ensemble IMPROVE Local mechanism memory outbreak Pneumonia prevalent Research Spread Sugeno integral virus [DOI] 10.1016/j.eswa.2022.117812 [Article Type] Research article
Safety and immunogenicity of COVID-19 vaccination in patients with hepatocellular carcinoma (CHESS-NMCID 2101): A multicenter prospective studyArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome anorexia BBIBP-CorV China CoronaVac coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccines dose enrolled Future HCC HCC patient hepatocellular Hepatocellular carcinoma immunogenicity inactivated Inactivated vaccine injection interquartile range Local median multicenter neutralizing antibody Odds ratio Pain Patient patients with HCC positive potential benefit Prospective Study risk Safe Safety Safety. second dose systemic adverse events transpeptidase vaccinated against COVID-19 vaccination Vaccinations Vaccine validation study variants was related [DOI] 10.1002/jmv.27992 PMC 바로가기
Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in LondonArticle Published on 2022-11-012022-11-16 Journal: The Lancet. Microbe [Category] SARS, 변종, 치료기술, [키워드] acquisition Assessing Asymptomatic children Community Contact Contamination Department eight Evidence FIVE Frequency Genome sequencing Health household contact household contacts IMPROVE incident index case Infection Innovation Laboratory Local London occur PCR testing positive positive PCR positive SARS-CoV-2 PCR Precaution Prevent prospective cohort public health pupil Pupils quantified reduced representing rising SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 transmission School Schools secondary transmission Spread supported symptomatic individual tested Testing throat swab Transmission transmission of SARS-CoV-2 variant Ventilation viral shedding was done Weekly with COVID-19 [DOI] 10.1016/S2666-5247(22)00124-0 PMC 바로가기
Spatiotemporal clusters and the socioeconomic determinants of COVID-19 in Toronto neighbourhoods, CanadaResearch article Published on 2022-11-012022-10-05 Journal: Spatial and spatio-temporal epidemiology [Category] 진단, 치료기술, [키워드] affecting Canada Cluster Clustering analysis COVID-19 determinant driver effective epidemiological explain identify Intervention Local Multiscale geographically weighted regression (mgwr) predictor Regression model regression models Space-time clusters Spatial regression spatiotemporal Toronto variable were used [DOI] 10.1016/j.sste.2022.100534 [Article Type] Research article
Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19Article Published on 2022-11-012022-11-16 Journal: Chest [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed association Bacteria bronchiolar CD8+ T-cell chemokine correlated COVID-19 CXCL8 Cytokines cytotoxic death Defense Diseases eight exploratory expression Extracellular fatal COVID-19 function heterogeneity IL-8 immune response immunohistochemistry infiltration Inflammation Inflammatory inherent leukocyte liver tissues Local lung Lungs mechanism Messenger RNA mRNA mRNA levels multiplexed immunofluorescence NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils neutrophils. no correlation pathogenic Patient polymerase chain pulmonary thrombi quantified Respiratory failure response SARS-CoV-2 severe COVID-19 shown T-lymphocyte the SARS-CoV-2 tissue tissue damage tissue viral load validation cohorts viral loads [DOI] 10.1016/j.chest.2022.06.007 PMC 바로가기
Monitoring of SARS-CoV-2 circulation using saliva testing in school children in Rome, ItalyArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] analyzed anticipated Asymptomatic children circulation collected COVID-19 COVID-19 diagnosis Isolation Italy Laboratory Local Molecular assay MONITOR monitoring Nasopharyngeal swab nine NPs NPSs Population positive positive test result representing Rome Saliva saliva sample saliva samples SARS-CoV-2 SARS-CoV-2 RNA School Surveillance surveillance. System tested virus transmission [DOI] 10.1016/j.ijid.2022.09.007 PMC 바로가기