Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature reviewArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] applied approach bioinformatics Bioinformatics analysis Biomarker Cancer Colorectal cancer complications of COVID-19 core gene Coronavirus disease 2019 COVID-19 COVID-19 complication DEGs Diseases drug drug candidates Effect effective feature Health highest identification identify idiopathic IPF literature review lung lung cancer Lung fibrosis Metastasis molecular morbidity and mortality Mortality pathway Patient patients positive pulmonary fibrosis reducing risk risk factor significantly Spread Systems biology the epidemic the SARS-CoV-2 virus Transcriptome treating COVID-19 Treatment [DOI] 10.1038/s41598-022-20040-x PMC 바로가기
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2′-O-ribose methyltransferasesArticle Published on 2022-09-012022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 치료제, [키워드] AHCY Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral drug antivirals attenuation Concomitant COVID-19 COVID-19 treatments Drug screening DZNep enzyme Ex vivo exhibit functional Host host-directed hyperinflammation identify Immune escape immunomodulatory effect in silico in vitro in vivo independent Infection Inflammation inhibitor Interaction Lung fibrosis marker Methylation methyltransferase pathogen reduce SAM SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Side effects Stage suppresse Treatment Viral RNA virus replication [DOI] 10.15252/embj.2022111608 PMC 바로가기
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
Residual lesions on chest-Xray after SARS-CoV-2 pneumonia: Identification of risk factorsCase Reports Published on 2022-05-132023-07-06 Journal: Medicina clínica [Category] COVID19(2023년), [키워드] chest X-ray coronavirus disease Enfermedad por coronavirus Fibrosis pulmonar Lung fibrosis Radiografía de tórax. [DOI] 10.1016/j.medcli.2021.04.001 PMC 바로가기 [Article Type] Case Reports
Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis Research Published on 2022-03-232022-10-05 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, [키워드] acute exacerbation acute lung injury Apoptosis approach disease Diseases etiology growth high mortality Idiopathic pulmonary fibrosis incurable inhibiting inhibition lung lung epithelial cell Lung fibrosis mechanism monoclonal antibody occur Pathogenesis peptide pulmonary fibrosis significantly Trigger [DOI] 10.1038/s41467-022-29064-3 [Article Type] Research
Potential “Therapeutic” Effects of Tocotrienol-Rich Fraction (TRF) and Carotene “Against” Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling PathwaysArticle Published on 2022-03-052022-10-31 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] administration alteration Anti-inflammatory antioxidant Apoptosis approach Bacterial biochemical BLM candidate carotene caused collagen Combination demonstrated develop disease downregulated downregulation drug Effect expressions Factors fibrosis fraction functions genetics histopathological histopathological finding hydroxyproline increased expression Inflammatory cytokine influences inhibit injection interstitial investigated Lung fibrosis Lung injury lung tissues management modulation molecular NF-κB NF-κB signaling Pathways post-COVID-19 patient Potential preventive effects Probability proinflammatory cytokines provided pulmonary pulmonary fibrosis rapid progress RAT reduction in reported shown significantly tocotrienol-rich fraction treated Treatment TRF upregulation variety viral infections [DOI] 10.3390/nu14051094 PMC 바로가기 [Article Type] Article
Diethylcarbamazine as potential treatment of COVID-19 lung fibrosisCorrespondence Published on 2022-03-012022-10-05 Journal: Medical Hypotheses [Category] 신약개발, 치료법, [키워드] Anti-inflammatory antiparasitic drug clinical study coronavirus disease COVID-19 COVID-19-related pulmonary fibrosis Diethylcarbamazine Drug repurposing immunomodulatory activities Lung fibrosis post-COVID-19 Potential treatment pulmonary fibrosis treat [DOI] 10.1016/j.mehy.2022.110774 [Article Type] Correspondence
Lung Function, Radiological Findings and Biomarkers of Fibrogenesis in a Cohort of COVID-19 Patients Six Months After Hospital DischargeResearch article Published on 2022-02-012022-10-05 Journal: Archivos de bronconeumología [Category] 바이오마커, [키워드] 6 minute-walk test 6-MWT6 minute-walk test 95% CI 95%CI acute respiratory distress syndrome age ARDSacute respiratory distress syndrome Biomarker BMIbody mass index body mass index change changes in Chest CT Chest radiography chronic obstructive pulmonary disease circulating Computed tomography COPDchronic obstructive pulmonary disease Coronavirus disease 2019 correlation COVID-19 COVID-19coronavirus disease 2019 CT scan CTComputed Tomography diffusing capacity for carbon monoxide diffusion discharge discharged patients DLCOdiffusing capacity for carbon monoxide elevated evaluate Factor female Fibrogenesis finding function functional GGOground-glass opacity Ground glass opacity ground-glass opacity HFNChigh flow nasal cannula oxygen high flow nasal cannula oxygen ILDinterstitial lung disease impairment IMVmechanical ventilation Interstitial lung disease involved lesion lung Lung fibrosis matrix metalloproteinases mechanical ventilation MMP1 MMP7 MMPmatrix metalloproteinases mMRCmodified British Medical Research Council modified British Medical Research Council Month multicenter NIVnon-invasive ventilation non-invasive ventilation parenchymal Patient patients with moderate performed Peripheral blood proportion prospective observational cohort pulmonary pulmonary fibrosis Pulmonary function test radiographic assessment of lung edema radiological radiological abnormality RALEradiographic assessment of lung edema respiratory parameters Result reverse transcriptase-polymerase chain reaction RT-PCRreverse transcriptase-polymerase chain reaction SARS-CoV-2 pneumonia SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SARSSevere Acute Respiratory Syndrome sEGFRsoluble epidermal growth factor receptor serum biomarker serum biomarkers Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 Severe COVID-19 pneumonia severe patients Sex soluble epidermal growth factor receptor Survivors vascular endothelial growth factor VEGFvascular endothelial growth factor [DOI] 10.1016/j.arbres.2021.08.014 [Article Type] Research article
The possible role of ursolic acid in Covid-19: A real game changerResearch article Published on 2022-02-012022-10-05 Journal: Clinical nutrition ESPEN [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료제, [키워드] ACE2 activity acute lung injury acute respiratory distress addition anti-inflammatory property antiparasitic Antiviral attenuate clinical trial Complication COVID-19 critical cases Cytopathic effect disease dose Effects enzyme exaggerated immune response Infection infections inflammatory reaction inhibit Lung fibrosis mitigate oxidative stress pandemic pathogenesis of SARS-CoV-2 pentacyclic pharmacological protease Protein Respiratory Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secondary metabolites syndrome therapeutic therapy Treatment ursolic acid virulent [DOI] 10.1016/j.clnesp.2021.12.030 [Article Type] Research article
Antemortem vs Postmortem Histopathologic and Ultrastructural Findings in Paired Transbronchial Biopsy Specimens and Lung Autopsy Samples From Three Patients With Confirmed SARS-CoV-2SARS-CoV-2가 확인된 3명의 환자로부터 한 쌍의 경기관지 생검 표본 및 폐 부검 샘플에서 사후 조직병리학적 및 미세구조적 소견 비교Article Published on 2022-01-062022-09-11 Journal: American journal of clinical pathology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alveolar alveolar damage Antemortem ARDS Autopsies Autopsy biopsy cause of death Chain Reaction change clinical evaluation Computed tomography Confirmed coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19-induced lung injury DAD death detectable died different time point different time points diffuse Diffuse alveolar damage disease enrolled fibrosis finding Fluorescence High-resolution histology Hospital admission In situ hybridization latency lung Lung fibrosis Lung injury Lung pathology one patient Organizing pneumonia pathologic Patient patients with COVID-19 performed pneumocyte Pneumonia polymerase chain polymerase chain reaction Postmortem progression reactive respiratory Respiratory failure reverse transcription reverse transcription polymerase chain reaction Sample SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimen Spread TBB the disease the patient tissue sample transbronchial upper airway upper airways Vascular Viral Viral load virus widespread [DOI] 10.1093/ajcp/aqab087 PMC 바로가기 [Article Type] Article