Lung inflammation – Page 2 – Communicable Diseases Research

Efficacy of salmeterol and magnesium isoglycyrrhizinate combination treatment in rats with chronic obstructive pulmonary disease

Research

Published on 2022-07-192022-10-05
Journal: Scientific Reports
[Category] 바이오마커, 치료제,

mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primates

mRNA-1273 백신 접종은 비인간 영장류에서 SARS-CoV-2 유발 폐 염증으로부터 보호합니다

Article

Published on 2022-07-082022-09-11
Journal: JCI Insight
[Category] COVID19(2023년), SARS, 변종,

[키워드] 48 hour 48 hours Antibody Response Antibody responses Antibody titer Bronchoalveolar lavage fluid CCL3 cellular Cellular immune response chemokines collected correlated COVID-19 CXCL10 dissemination dose-dependent manner expression Genes Human IFIT1 immune immunology immunology. independent induction Inflammation Inflammatory ISG15 less limit Lower respiratory tract lung Lung inflammation mRNA mRNA-1273 MX1 observation Pathogenesis profile PROTECT replicated respiratory tract restrict viral replication rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 spike SARS-CoV-2 strain serum Support suppressed These data transcriptomic USA-WA1/2020 vaccination Vaccine-induced immunity variant of SARS-CoV-2 viral infection viral replication Viral RNA
[DOI] 10.1172/jci.insight.160039 PMC 바로가기 [Article Type] Article

Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum

폴리(I:C) 플러스 명반과 관련된 SARS-CoV-2 삼량체 스파이크 단백질의 면역원성

Article

Published on 2022-06-302022-09-12
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] addition adjuvant adjuvants alum antibody B cell BALF Bronchoalveolar lavage fluid CD4 CD8 Cellular immune response Combination domain ELISA enzyme evaluated expected germinal centers IgA IgG IgG anti-spike antibody IgG1 IgG2a immunization immunogenicity immunosorbent in vitro inactivated induce intradermal route lung Lung inflammation mice Neutralization assay Neutralizing titer neutralizing titers neutrophil recruitment New Poly (I:C) poly(I:C positive prefusion produced producing Protein RBD reduced reduction in required SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 virus serum spike Spike protein Subtypes supported T cell Th1 Th1 phenotype the SARS-CoV-2 trimeric vaccination Vaccination strategy Vaccine vaccine.
[DOI] 10.3389/fimmu.2022.884760 PMC 바로가기 [Article Type] Article

Intranasal immunization with avian paramyxovirus type 3 expressing SARS-CoV-2 spike protein protects hamsters against SARS-CoV-2

Research

Published on 2022-06-282022-10-05
Journal: NPJ Vaccines
[Category] 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome Administered Beta clinical development controls coronavirus current domain dose Express expressing hamster hamsters Human IgA response Immunity immunization immunized immunogenic intranasal lack Lineage Lower respiratory tract Lung inflammation neutralized pre-existing immunity prefusion conformation proline substitution PROTECT Protective Protein replicated Replication respiratory tract response S-2P SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S protein SARS-CoV-2 spike protein serum IgG Serum neutralizing antibody stability stimulate the S protein the SARS-CoV-2 undetectable upper respiratory tract Vaccine vaccine candidates variants of concern WA1/2020 weight loss
[DOI] 10.1038/s41541-022-00493-x [Article Type] Research

Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice

SARS-CoV-2에 감염된 마우스의 폐에서 염증의 사이토카인 및 지질 매개체

Article

Published on 2022-06-242022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Analysis analyzed animal animal model animal models Blood blood clot Blood clots characterized chemokine chemokines circulating clinical manifestation Concentration coronavirus 2 coronavirus disease coronavirus disease 19 correlated COVID-19 Cytokines D-dimer D-dimers different time point different time points elevated ethanolamide event events Features Genes glycerol glycine hallmark highlight histology Human hydroxy indicated Infection Inflammation inflammatory mediator Inflammatory mediators interferons K18-ACE2 knowledge leukocyte leukocyte infiltration Lipid lipid mediator lipid mediators of inflammation lipids lung Lung inflammation lung tissue lung tissues lung viral load Lungs mass spectrometry Measures mediator mice modulation Other Pathogenesis pathogenesis. pathology pathophysiological performed PGF plasma Post-infection produced prostaglandin reduced Replication RNA-seq analysis robust SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe COVID-19 significantly Support Tandem mass spectrometry therapeutic strategy transcriptomic transgenic mice treat uninfected vasculature viral replication
[DOI] 10.3389/fimmu.2022.893792 PMC 바로가기 [Article Type] Article

Exploring the Role of Low-Density Neutrophils During Mycobacterium tuberculosis Infection

결핵균 감염 중 저밀도 호중구의 역할 탐색

Review

Published on 2022-06-212022-09-12
Journal: Frontiers in Cellular and Infection Microbiology
[Category] MERS, 진단,

Lethal synergy between SARS-CoV-2 and Streptococcus pneumoniae in hACE2 mice and protective efficacy of vaccination

hACE2 마우스에서 SARS-CoV-2와 Streptococcus pneumoniae 간의 치명적인 시너지 효과와 예방 접종의 보호 효능

Article

Published on 2022-06-082022-09-12
Journal: JCI Insight
[Category] COVID19(2023년), MERS, SARS, 진단,

Inflammasome activation in infected macrophages drives COVID-19 pathology

감염된 대식세포의 인플라마좀 활성화는 COVID-19 병리를 유발합니다

Article

Published on 2022-06-012022-09-12
Journal: Nature
[Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] ACE2 receptors activate Activation antibody attenuate blockade blocking cascade CD16 characterized contributing to COVID-19 COVID-19 pathology Critical disease downstream host infection Human immune system human macrophage humanized hyperinflammatory state IFN IL-1 IL-18 immune in vivo Infection Infectious virus Inflammasome inflammasome activation inflammasomes Inflammatory cytokine inflammatory cytokine production inflammatory macrophages Inflammatory response interferon Lung inflammation Lung pathology Lungs Macrophage macrophages NLRP3 inflammasome overactive pathology pathway Prevent pyroptosis Remdesivir Replication required SARS-CoV-2 SARS-COV-2 infection Stage sustained undergo viral replication Viral RNA
[DOI] 10.1038/s41586-022-04802-1 PMC 바로가기 [Article Type] Article

Lung targeted liposomes for treating ARDS

ARDS 치료를 위한 폐 표적 리포솜

Article

Published on 2022-06-012022-09-11
Journal: Journal of controlled release : official journal o
[Category] 치료제,

[키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary Pulmonary. reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed
[DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article

Salivary immunity of elite collegiate American football players infected with SARS-CoV-2 normalizes following isolation

Research

Published on 2022-05-312022-10-05
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 바이오마커,