Potential anti-COVID-19 activity of Egyptian propolis using computational modelingShort Communication Published on 2021-02-012022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] addition Analysis Anti-COVID-19 Antiviral agents binding characterized collected computational modeling COVID-19 enzyme geographical area Lopinavir macromolecule material pandemic Potential predict Propolis protease Remdesivir Result RNA-dependent RNA polymerase spike protein S1 umifenovir [DOI] 10.2217/fvl-2020-0329 PMC 바로가기 [Article Type] Short Communication
DeepTracer for fast de novo cryo-EM protein structure modeling and special studies on CoV-related complexes530 Published on 2021-01-122022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] Accuracy Amino acid applied assist automated average cellular and molecular complex complexes Course Coverage cryo-EM de novo deep learning-based method determine disease drugs Efficiency electron explain High-resolution human cell information Interaction macromolecular macromolecule mechanism Microscopy modeling multichain Protein protein complex provide receptors residue robust SARS-CoV-2 viral sequence Significance Structure therapeutic Vaccine [DOI] 10.1073/pnas.2017525118 PMC 바로가기 [Article Type] 530
Antiviral activity of lambda-carrageenan against influenza viruses and severe acute respiratory syndrome coronavirus 2인플루엔자 바이러스 및 중증급성호흡기증후군 코로나바이러스 2에 대한 람다-카라기난의 항바이러스 활성Article Published on 2021-01-122022-09-10 Journal: Scientific Reports [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Antiviral antiviral activity antiviral agent body weight broad spectrum cause Cell culture cell lysate cell lysates cell surface receptor cell surface receptors circulating Concentration coronavirus culture supernatant culture supernatants dose-dependent manner Drug discovery enveloped RNA viruses expression host cell host cells Influenza influenza A Influenza virus inhibited intranasal lambda-carrageenan macromolecule mice Microbiology Mortality plaque Plaque titration polysaccharide preventing infection progeny purified reduced reductions in respiratory respiratory diseases respiratory viruses RNA viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus sulfated suppressed Toxicity Viral viral challenge Viral protein Viral proteins virus virus entry virus production viruses western blot Western blot analysis [DOI] 10.1038/s41598-020-80896-9 PMC 바로가기 [Article Type] Article
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciencesAcademicSubjects/SCI00010 Published on 2021-01-082022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, MERS, [키워드] 3D structure America applied Complete COVID-19 described example feature global pandemic host cell include macromolecular macromolecule Magnetic resonance spectroscopy Microscopy New nuclear Oceania operator PDB Protein Protein Data Bank released Research researchers resource resources SARS-CoV-2 protein Structure [DOI] 10.1093/nar/gkaa1038 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Transcriptomic Analysis of Respiratory Tissue and Cell Line Models to Examine Glycosylation Machinery during SARS-CoV-2 InfectionSARS-CoV-2 감염 중 당화 기계를 검사하기 위한 호흡기 조직 및 세포주 모델의 전사체 분석Article Published on 2021-01-082022-09-10 Journal: Viruses [Category] MERS, 바이오마커, [키워드] addition affecting Analysis approach biological significance Biomarker correlation COVID-19 immunity cytokine Cytokine storm database differentially expressed downstream epitope Epitopes expression functional functional enrichment Functional genomics glycan glycans glycosylation glycosylation pathway glycosylation pathways Host immune response host inflammatory response hypothetical immune function immune response immunomodulatory implicated in silico Infection infectious agents inflammatory signaling LINE Localization macromolecule macromolecules marker Model modulated modulating negative and positive pathogen Pathways performed post-translational modification Protein Proteoglycan proteoglycans receptor Repository respiratory SARS-CoV-2 SARS-COV-2 infection Stratification susceptibility therapeutic Transcription transcriptomic analysis Treatment Viral [DOI] 10.3390/v13010082 PMC 바로가기 [Article Type] Article
Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical TrialsReview Published on 2020-07-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome block caused Clathrin-mediated endocytosis clinical clinical trial clinical trials combating coronavirus Coronavirus-2 COVID-19 described disease early stage effective endocytosis ENhance enzyme facilitate Health care system Host host protein include Infection lack life macromolecule mechanism mechanisms monoclonal antibodies pandemic polypeptides Potential presenting Prevent protease PROTECT reported researcher SARS-CoV-2 serine 2 small molecule Spike protein Stage structures sulfated polysaccharides target Therapeutics TMPRSS2 transmembrane treat Vaccine viral entry viral fusion viral infection viral life cycle viral spike protein [DOI] 10.3390/ijms21155224 PMC 바로가기 [Article Type] Review
Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico AnalysisMicrobiology Published on 2020-07-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3CLpro Against anti-SARS-CoV-2 therapeutics catalytic dyad China complex coronavirus COVID-19 disease docking study drug Drug repurposing functional in silico in silico analysis Infection interfere macromolecule main-protease (3CLpro) novel coronavirus SARS-CoV-2 NTP outcome oxolinic acid polymerase positive predicted quinoline based-drugs RdRP RNA-dependent RNA-polymerase SARS-CoV-2 SARS-CoV-2 RdRp seeking specific treatment spike-ACE2 complex Spread spread to suggested the WHO treat Treatment viral entry [DOI] 10.3389/fmicb.2020.01796 PMC 바로가기 [Article Type] Microbiology
Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine componentsArticle Published on 2014-08-152024-08-29 Journal: Biochemical and Biophysical Research Communications [Category] 말라리아, [키워드] Antimalarial-vaccine dendrimer macromolecule PfASP Plasmodium
The Transcription Factor BcLTF1 Regulates Virulence and Light Responses in the Necrotrophic Plant Pathogen Botrytis cinerea전사 인자 BcLTF1은 괴사성 식물 병원체 Botrytis cinerea에서 독성과 빛 반응을 조절합니다Research Article Published on 2014-01-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulation addition Affect alternative oxidase alternative respiration enzymes antioxidants AOX apothecia applied approach arising Aspergillus nidulan Aspergillus nidulans Author BcLTF1 bctlf1 Botrytis cinerea caused characterized circadian rhythm conditions conidia continuous light Deletion dependent on detoxification detrimental effect detrimental effects dicotyledonous plant differentiation dispersal ecological ecological niche equilibrium Evidence exogenously exposure to expression expression level expression levels expression of gene Factor fertilization filamentous fungi fruiting bodies function fungal fungal pathogen fungi fungus GATA transcription factor Gene gene encoding Genes gray mold disease gray mold diseases growth rate growth rates homoeostasis homologue Host host infection hypersensitivity illumination impair Increased increased expression induce Infection LIGHT macroconidia macromolecule macromolecules majority metabolism Microarray analyses microarray analysis microconidia mitochondrial mitochondrial dysfunction modulated mutant mutants necrotrophic pathogen necrotrophic pathogen Botrytis cinerea Neurospora crassa NsdD Organisms Orientation over-expression overexpression oxidative stress oxygen Pathogens photomorphogenesis photoreceptor phototropism pigments plant plants predicted propagule propagules PROTECT random mutagenesis reactive oxygen species reactive oxygen specy Regulation reproductive required respiration enzymes respond response restoration ROS scavenging sclerotia Secondary metabolism sexual reproduction singlet oxygen spores Structure structures SUB-1 survival TF 1 transcription factor transcriptional level virulence [DOI] 10.1371/journal.pgen.1004040 PMC 바로가기 [Article Type] Research Article