Locked in a pro-inflammatory stateEditorial Published on 2022-07-072023-07-09 Journal: eLife [Category] COVID19(2023년), [키워드] COVID-19 Efferocytosis Human hyperinflammation immunology Inflammation macrophage polarization SARS-CoV-2 tissue repair [DOI] 10.7554/eLife.80699 PMC 바로가기 [Article Type] Editorial
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cellsArticle Published on 2022-06-062023-07-09 Journal: eLife [Category] COVID19(2023년), [키워드] COVID-19 Efferocytosis Human hyperinflammation immunology Inflammation macrophage polarization SARS-CoV-2 tissue repair [DOI] 10.7554/eLife.74443 PMC 바로가기
Multi-Design Differential Expression Profiling of COVID-19 Lung Autopsy Specimens Reveals Significantly Deregulated Inflammatory Pathways and SFTPC Impaired TranscriptionCOVID-19 폐 부검 표본의 다중 디자인 차등 발현 프로파일링은 상당히 규제 완화된 염증 경로 및 SFTPC 손상된 전사를 나타냅니다Article Published on 2022-03-162022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] Activation Autopsy carried cathepsin Cathepsin C CD163 CFB Clinical diagnosis complement Complement activation controls COVID-19 COVID-19 patient COVID-19-related death CTSC deaths deregulation develop differential expression effective effective therapy FFPE formalin formalin-fixed paraffin-embedded Gene expression profiling had no high viral load IFIT1 immune signature immunohistochemistry Impaired Inflammation ISG15 lung lung damage Macrophage macrophage polarization mechanism MS4A4A Nasopharyngeal swab OAS1 overexpression paraffin pathway pharmacological strategies PKM positive potential therapeutic targets Prevent probe Profiling Protein protein C pulmonary viral quantified required Respiratory disease RNA RNA-Seq RSAD2 SARS-CoV-2 SARS-COV-2 infection selected Seven SFTPC Siglec-1 SIGLEC1 signaling pathway specimen tissue sample tissue samples transcriptomic Transcriptomic profiling type I interferon Viral load were used [DOI] 10.3390/cells11061011 PMC 바로가기 [Article Type] Article
Modulation of Macrophage Polarization by Viruses: Turning Off/On Host Antiviral ResponsesMicrobiology Published on 2022-02-112022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition activated macrophages Anti-inflammatory antigen-presenting cell Antiviral antiviral response antiviral responses antivirals classical Critical Defense expected facilitate hosts immune evasion impairing inhibiting invading pathogens Macrophage macrophage phenotype macrophage polarization macrophages mechanism mechanisms phenotype polarization proinflammatory Regulation regulation network Regulatory Replication response therapeutic target Turning viral infections virus [DOI] 10.3389/fmicb.2022.839585 PMC 바로가기 [Article Type] Microbiology
SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice via NF-ĸB ActivationSARS-CoV-2 N 단백질은 NF-ĸB 활성화를 통해 쥐의 급성 폐 손상을 유발합니다Immunology Published on 2021-12-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료법, [키워드] acute lung injury acute respiratory syndrome addition administration antibody blocked body fluid body fluids Bone marrow C57BL/6 cell count Contamination coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines denaturation elevated expression in vitro induce Infection inhibitor Injury intratracheal administration lipopolysaccharide LPS lung Lung injury Macrophage macrophage polarization macrophages mice N-protein neutrophil neutrophil infiltration NF- kappa B nuclear nucleocapsid (N) protein nucleocapsid protein p65 pathway Phosphorylation Polymyxin B produced Proinflammatory cytokine proinflammatory cytokines promoted Protein PYRROLIDINE pyrrolidine dithiocarbamate recombinant reported respiratory Result SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid therapeutic target therapeutic targets toxic Treatment triggered [DOI] 10.3389/fimmu.2021.791753 PMC 바로가기 [Article Type] Immunology
Traditional Chinese Medicine, Qingfei Paidu Decoction and Xuanfei Baidu Decoction, Inhibited Cytokine Production via NF-κB Signaling Pathway in Macrophages: Implications for Coronavirus Disease 2019 (COVID-19) TherapyPharmacology Published on 2021-10-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] A549 cell A549 cells Activation addition analyzed anti-inflammatory activity Baidu Cell chemokine Chinese COVID-19 Cytokine storm Decoction defined demonstrated Efficacy ELISA evaluated expression expression level feature host immunity IFN IFN signaling pathway IFNα and IFNβ immune response in vitro infected with SARS-CoV-2 inhibited Innate immunity interferon-stimulated gene interleukin-6 investigated ISGs IκBα Ligand LPS Macrophage macrophage polarization macrophages marker mechanism Medicine modulation monocyte chemotactic protein-1 network pharmacology neutral red NF-κB signaling pathway NF-κB NF-κB signaling p65 pathway Patient PCR Phosphorylation pro-inflammatory pro-inflammatory cytokine Production Regulation robust RT-qPCR SARS-CoV-2 shown signaling pathway significantly suppressed THP-1 Traditional Traditional Chinese medicine treated Treatment tumor necrosis factor-α type 1 interferon were measured [DOI] 10.3389/fphar.2021.722126 PMC 바로가기 [Article Type] Pharmacology
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection Research Published on 2021-10-192022-10-05 Journal: Nature Immunology [Category] SARS, 변종, 치료제, [키워드] activity Altered Analysis Antigen presentation contribute Defense driven by enzyme Enzymes expression generate Host immune response implicated induce Infection inflammatory gene Influenza Influenza virus interferon-stimulated gene involved ISG15 Macrophage macrophage polarization Macrophage response mechanisms mutant Papain-like protease phenotype PLPro pro-inflammatory pro-inflammatory cytokines Protein proteomic purified SARS-CoV-2 SARS-COV-2 infection Secretome substrate the cytokine storm Trigger triggered virus while wild-type Zika Zika virus [DOI] 10.1038/s41590-021-01035-8 [Article Type] Research
COVID-19: Mechanistic Model of the African Paradox Supports the Central Role of the NF-κB PathwayCovid-19 : 아프리카 역설의 기계적 모델은 NF-κB 경로의 중심 역할을 지원합니다.Review Published on 2021-09-212022-09-10 Journal: Viruses [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected African African paradox age America Americas Analysis chemokine coronavirus correlation Coverage COVID-19 cytokine Cytokine storm death death rates distribution Duffy antigen receptor for chemokines (DARC) endemics epidemiological Europe Factor Factors focus Genetic genetic factors global pandemic helminth infection highlight hypothese immune Immune status immunological induction patterns Infection infection rate less macrophage polarization malaria malaria incidence medication Model Mortality much lower NF-κB NF-κB NF-κB signaling paradox pathological mechanism pathway reported respiratory role SARS-CoV-2 target the disease Treatment strategies [DOI] 10.3390/v13091887 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril)Immunology Published on 2021-09-202022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE ACE2 activated Activation Analysis analyzed angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor Apoptosis binding Blood Cell cells changed circulation component conditioned media coronavirus CoV cytokine expression Effect Effects Endothelial cell entry of SARS-CoV-2 expression glycoprotein HUVEC cells increase in Inflammation Inflammatory marker inhibitor intracellular calcium intracellular cytokine involved Local Macrophage macrophage polarization macrophages MCP-1 MHC-II modulation monocyte/macrophages mononuclear cell oxidative stress pathway PBMC PBMCs Perindopril Peripheral blood phenotype Potential proinflammatory Proteins Proteomic analysis purified receptors reduced regulated response role ROS S protein SARS-CoV-2 sensitivity significantly increased spike Spike protein stimulated Stimulation systemically the S protein THP-1 TNFα treating Treatment upregulation Vascular viability was used [DOI] 10.3389/fimmu.2021.728896 PMC 바로가기 [Article Type] Immunology
Clinicopathologic and Transcriptomic Analysis of Radiation-Induced Lung Injury in Nonhuman PrimatesResearch article Published on 2021-09-012022-10-05 Journal: International journal of radiation oncology, biolo [Category] 비임상, [키워드] addition Analysis approach ATP12A BAL Biomarker Bronchoalveolar lavage CCL11 CCL2 CLDN10 collected Computed tomography dysregulated early phase epithelial cells Evolution expression GJB2 greater highlight histologic immunohistochemistry involved late phase LPA lung Lung fibrosis Lung injury lung tissue M2-like phenotype Macrophage macrophage polarization material mechanism molecular Mortality NHP NHPs occur Pathogenesis Plasma cytokine plasma samples potential therapeutic target primate progression protein expression provide Radiation radiation exposure respiratory rates Result rhesus RNA sequencing SERPINA3 Signaling TGF-β TGF-β1 TOX3 transcript transcriptomic analysis transcriptomic data Variability [DOI] 10.1016/j.ijrobp.2021.03.058 [Article Type] Research article