Reverse Transcription-Loop-Mediated Isothermal Amplification-CRISPR-Cas13a Technology as a Promising Diagnostic Tool for SARS-CoV-2Article Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome caused change clinical samples coronavirus coronavirus disease COVID-19 CRISPR-Ca CRISPR-Cas CRISPR-Cas13 cycle threshold deaths develop Diagnosis diagnosis. diagnostic Diagnostic method early diagnosis effort exhibit highlighting isothermal isothermal amplification maintain Molecular diagnosis nasopharyngeal sample Negative predictive value New coronavirus NPV pandemic performed persist Positive predictive value PPV Prevalence protocol reaction required researcher RNA extraction RNA molecules RT-LAMP SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sensitivity Sensitivity and specificity single nucleotide single-stranded specificity technology viral loads [DOI] 10.1128/spectrum.02398-22 PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution substitution. T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
Performing under Pressure: Insights into the Diagnostic Testing Burden at a UK National Health Service Clinical Virology Laboratory during the SARS-CoV-2 PandemicArticle Published on 2022-10-122022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] burden clinical clinical sample COVID-19 Department detect diagnostics dramatic increase genomic Host immune response increase in information insight Laboratory Logistic maintain National Health Service NHS NHS laboratories NHS laboratory non-SARS-CoV-2 Novel coronavirus pandemic Performing routine SARS-CoV-2 SARS-CoV-2 testing Testing testing. the SARS-CoV-2 viral infection Virology virus [DOI] 10.3390/v14102233 PMC 바로가기
Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccinationArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody CD4 CD4+ CD4+ T cells CD8 CD8+ CD8+ T cells Cellular immune response competent coronavirus COVID-19 COVID-19 vaccination develop dose elicited ELISPOT exhibited had no healthy individuals humoral ICU immune protection immune response individual individuals information intensive care intensive care unit workers lack maintain mRNA mRNA COVID-19 vaccines mRNA vaccine neutralizing antibody proportion Protein protein S reactive receiving reduction in SARS-CoV-2 SARS-CoV-2-specific T cell Seroconversion seronegative Specific T-cell response susceptibility T cell T cell response T cells T lymphocyte T-cell the S protein the SARS-CoV-2 the spike protein vaccination vaccination. viral infection Viral protein [DOI] 10.3389/fimmu.2022.942192 PMC 바로가기
Longitudinal cellular and humoral immune responses after triple BNT162b2 and fourth full-dose mRNA-1273 vaccination in haemodialysis patientsArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] ACE2 binding addition administration analysed anti-RBD B.1 binding BNT162b2 boost immunity cellular Control controls COVID-19 COVID-19 vaccination Decline declining Delta detectable dialysis dose doses group Haemodialysis Haemodialysis patient humoral humoral immune response Humoral immunity IgG IgG response immune immune evasion immune protection immunoassays Immunocompromised individual individuals information interferon γ knowledge longitudinal longitudinal response maintain mixed mRNA vaccination mRNA mRNA vaccination mRNA-1273 mucosal omicron Omicron variant of concern Patient patients Prevent protective immunity protective immunity. RBD reached regimen remained respond poorly restored SARS-CoV-2 vaccination SARS-CoV-2 variant second vaccination severe COVID-19 significantly increased spike subsequent Support T-cell Response tested the receptor-binding domain vaccination Vaccine variant variants of concern [DOI] 10.3389/fimmu.2022.1004045 PMC 바로가기
Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancerArticle Published on 2022-10-032022-11-16 Journal: Cell Death & Disease [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, [키워드] acute respiratory syndrome AKT Cancer Cell Comorbidity coronavirus coronavirus disease COVID-19 de novo death deregulated drug Drug discovery Evidence feedback homeostasis homeostatic Infection Interaction maintain mechanism opposite pandemic pathogen pathway Pathways progression recent reduce regulate Regulation response responsible SARS-CoV SARS-CoV-2 SARS-COV-2 infection shown Signaling signaling cascade significantly survival therapeutic purposes Topic Treatment UPR viral infection viral infections [DOI] 10.1038/s41419-022-05250-5 PMC 바로가기
Care for adults with COVID-19: living guidelines from the National COVID-19 Clinical Evidence TaskforceArticle Published on 2022-10-032022-11-15 Journal: The Medical journal of Australia [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis anticoagulation Antiviral agents Baricitinib benefit change clinical clinical trial Combination coronavirus disease Corticosteroids COVID-19 disease disease severity drug treatment eight Endotracheal intubation Evidence facilitated Health include Inhaled maintain management Mild molnupiravir nine Patient people with COVID-19 positive airway pressure Primary Health Care prone positioning Prophylactic Prophylaxis Public public health. randomised recommendation recommendations Remdesivir Respiratory Support sarilumab subsequent supplemental oxygen Support supportive care systemic corticosteroids therapy Tocilizumab Treatment trials Venous Thromboembolism with COVID-19 [DOI] 10.5694/mja2.51718 PMC 바로가기
Increases in symptoms of depression and anxiety in adults during the initial phases of the COVID-19 pandemic are limited to those with less resources: Results from the Lifelines Cohort StudyResearch article Published on 2022-10-012022-10-05 Journal: Journal of psychiatric research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] age agency And personality Anxiety anxiety symptoms association average baseline Capital class condition COVID COVID-19 COVID-19 cohort COVID-19 pandemic Depression element ENhance finding Health health condition increase increase in individual individuals initial Latent less maintain mental health MOST number of symptom obesity Odds ratio predicted Probability ranged receive reported reporting symptom Research resource Result socioeconomic status subsequent Symptom symptoms of depression the mean trajectory unlikely were used [DOI] 10.1016/j.jpsychires.2022.07.011 [Article Type] Research article
Catching BETs by virusesArticle Published on 2022-10-012022-11-16 Journal: Biochimica et biophysica acta. Gene regulatory mechanisms [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acetylated acetylation being BET BRD4 bromodomain cellular chromatin component Critical docking domain envelope protein ET domain evade function Genome highlight Histones Host host cell innate immune response Interaction maintain mechanism Protein SARS-CoV-2 target transcriptional regulators viral infection Viral protein Viral proteins virus virus. viruses [DOI] 10.1016/j.bbagrm.2022.194859 PMC 바로가기
Maintaining a social license to operate for wastewater-based monitoring: The case of managing infectious disease and the COVID-19 pandemicResearch article Published on 2022-10-012022-10-05 Journal: Journal of environmental management [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] benefit Community COVID-19 COVID-19 pandemic domain help highlight Impact Infectious disease information lockdown maintain maintaining measure offer pandemic positive Prevent public health Public health intervention required researcher SARS-CoV-2 detection Social license to operate Support Surveillance the SARS-CoV-2 wastewater Wastewater monitoring and management wastewater surveillance Wastewater-based epidemiology widespread [DOI] 10.1016/j.jenvman.2022.115819 [Article Type] Research article