mapped – Page 2 – Communicable Diseases Research

Mixed-methods process evaluation of a residence-based SARS-CoV-2 testing participation pilot on a UK university campus during the COVID-19 pandemic

COVID-19 전염병 동안 영국 대학 캠퍼스의 거주 기반 SARS-CoV-2 테스트 참여 파일럿의 혼합 방법 프로세스 평가

Article

Published on 2022-08-022022-09-11
Journal: BMC Public Health
[Category] SARS, 변종,

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

SARS-CoV-2 Omicron은 세포 진입 경로가 변경된 면역 탈출 변종입니다.

Article

Published on 2022-08-012022-09-11
Journal: Nature Microbiology
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단,

[키워드] Amino acid antigenicity B.1.1.529 BNT162b2 booster vaccination Cell cell entry Cell fusion ChAdOx1 changes in cornerstone COVID-19 described determined by Effectiveness endosomal entry endosomal entry pathway Immune escape Impaired in vitro increasingly individual induce mapped mRNA mRNA-1273 Mutation neutralization omicron Omicron variant Omicron variants pathogenicity pathway phenotype public health Receptor-binding domain reduction in Region replicative restored S2 domain SARS-CoV-2 sera Spike protein Spread Syncytia the receptor-binding domain the spike protein These data TMPRSS2 transmissible variant underlie Vaccine variant VoC VOCs was determined
[DOI] 10.1038/s41564-022-01143-7 PMC 바로가기 [Article Type] Article

Structural basis of Omicron immune evasion: A comparative computational study

오미크론 면역 회피의 구조적 기반: 비교 전산 연구

Article

Published on 2022-08-012022-09-11
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 Affect analysis angiotensin antibody binding affinities binding affinity Compromised Compromised neutralisation Critical Delta develop effective Effectiveness Efficacy evaluated explain immune Immune escape immune evasion immunogenic interact Interaction interface mapped molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation neutralisation Neutralising Antibodies neutralising antibody new strain omicron Omicron variant Protein RBD Receptor binding domain receptors reported robust S protein SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 variants. several variants Spike protein the antibody the binding affinity the spike protein Vaccine Vaccine design variant variants variants of concern virus
[DOI] 10.1016/j.compbiomed.2022.105758 PMC 바로가기 [Article Type] Article

Rapid displacement of SARS-CoV-2 variant Delta by Omicron revealed by allele-specific PCR in wastewater

폐수에서 대립 유전자 특이적 PCR로 밝혀진 Omicron에 의한 SARS-CoV-2 변이형 Delta의 빠른 변위

Article

Published on 2022-08-012022-09-11
Journal: Water research
[Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

[키워드] Accuracy allele Alpha B.1.1.529 Clinical studies clinical study Community complement Concentration COVID-19 Delta delta variant demonstrated detect distribution Health immune evasion Infection influent Italy mapped measure Mutation omicron Omicron variant PCR Public health responses qPCR Quantitative Rapid report RNA concentrations RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants Support Surveillance target These data Transmissibility Treatment triggered utility vaccination rates Vaccine breakthrough variant variant frequencies variant frequency VoC wastewater Wastewater.
[DOI] 10.1016/j.watres.2022.118809 PMC 바로가기 [Article Type] Article

Assessing temporal correlation in environmental risk factors to design efficient area-specific COVID-19 regulations: Delhi based case study

Research

Published on 2022-07-282022-10-05
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 치료기술, 치료법,

A Comparison of Bioinformatics Pipelines for Enrichment Illumina Next Generation Sequencing Systems in Detecting SARS-CoV-2 Virus Strains

SARS-CoV-2 바이러스 균주 검출 시 Illumina 차세대 시퀀싱 시스템 강화를 위한 생물정보학 파이프라인 비교

Comparative Study

Published on 2022-07-262022-09-11
Journal: Genes
[Category] COVID19(2023년), SARS, 치료기술, 치료제,

[키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Amino acid bioinformatics bioinformatics pipeline capture method characterization coronavirus 2 coronavirus disease Coronavirus disease 2019 Coverage COVID-19 Critical Deletion downstream enrichment enrichment. full-length SARS-CoV-2 genome Generation Hope Human genome Illumina Indonesia insertion limitation Major mapped mapping metagenomic mutations next generation sequencing NGS normal nucleotide nucleotide substitution nucleotide substitutions pandemic Panel Previous studies previous study reads respiratory respiratory virus respiratory viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 strain SARS-CoV-2 strains sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus situation SNPs strain Strains System table the SARS-CoV-2 genome utilization Variation virus worldwide pandemic worsening
[DOI] 10.3390/genes13081330 PMC 바로가기 [Article Type] Comparative Study

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases

조직간 단세포 기질 아틀라스는 4가지 만성 염증성 질환에서 공유된 병리학적 섬유아세포 표현형을 식별합니다.

Article

Published on 2022-07-082022-09-11
Journal: Med (New York, N.Y.)
[Category] 비임상,

[키워드] Activation affected animal model animal models Arthritis atlas atopic dermatitis breath CCL19 chronic inflammatory disease chronic inflammatory diseases Clusters COL3A1 Critical CXCL10 disease Diseases donors exacerbated fibroblast fibroblasts Foundational research heterogeneity Hoffmann-La Roche identify immune individual inflamed tissue Inflammation Inflammatory bowel disease Inflammatory diseases integration interstitial Interstitial lung disease intestinal inflammation intestine joint lack lung Lung disease Lungs mapped organ systems Pathogenesis pathogenic pathway Pathways phenotype Phenotypes pro-inflammatory reveal rheumatoid arthritis Roche salivary gland salivary glands scRNA-seq single-cell Single-cell RNA sequencing Sjögren's syndrome SPARC stromal syndrome synovium therapeutic target ulcerative colitis ulcerative colitis.
[DOI] 10.1016/j.medj.2022.05.002 PMC 바로가기 [Article Type] Article

SARS-CoV-2 variants preferentially emerge at intrinsically disordered protein sites helping immune evasion

Article

Published on 2022-07-012022-11-16
Journal: The Febs Journal
[Category] COVID19(2023년), SARS, 변종,

Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing

단일 세포 RNA 시퀀싱으로 밝혀진 COVID-19 회복기 개인의 면역 기능

Article

Published on 2022-07-012022-09-11
Journal: International immunopharmacology
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Activation addition B cell B cell subset B cells Bioinformatics analysis biological processe biological processes CD4 CD8 Cell cell receptor cell-cell adhesion clonal expansions Cluster convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent individual convalescent individuals convalescent patient Convalescent patients COVID-19 Critical declined decreased expression differentiation downregulation effector memory feature function functions GNLY HLA class I HLA class II HLA class II genes humoral immune response Humoral immunity immune protection immune response immune responses increased expression infections Innate innate immune responses Innate immunity Interferon-gamma involved leukocyte mapped marginal zone mechanism Migration moderate natural infection neutrophil Peripheral blood peripheral blood samples phenotypic reflected Regulation Reinfection retained RNA SARS-CoV-2 SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses severe cases single cell RNA sequencing Single-cell RNA sequencing subjects subset sustained T cell T cell activation T cell response T/B cell receptor repertoire. TCR upregulation was increased weakened with COVID-19 zone
[DOI] 10.1016/j.intimp.2022.108767 PMC 바로가기 [Article Type] Article

A highly photostable and bright green fluorescent protein

광안정성이 높고 밝은 녹색 형광 단백질

Article

Published on 2022-07-012022-09-11
Journal: Nature biotechnology
[Category] Fulltext, MERS, 변종,