Robust temporal map of human in vitro myelopoiesis using single-cell genomics Research Published on 2022-05-242022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Cell dendritic cell described develop Effect feature fetal generate Hematopoiesis Hematopoietic stem cell homeostasis Immunity immunotherapies imperative in vitro in vivo integration lineages Macrophage macrophages mast cell molecular Monocytes myeloid myeloid cell pluripotent stem cell protocol Regulatory Research resource single-cell single-cell genomics therapeutic transcription factor [DOI] 10.1038/s41467-022-30557-4 [Article Type] Research
Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in miceSARS-CoV-2 복제를 감소시키고 마우스에서 염증 유발 폐 손상을 완화하기 위한 항히스타민제와 렘데시비르의 조합 이점Article Published on 2022-05-182022-09-11 Journal: Zoological research [Category] COVID19(2023년), SARS, 치료제, [키워드] alveolar antagonist Anti-inflammatory Anti-inflammatory therapy Antihistamine Antihistamines Antiviral antiviral drug antiviral therapy benefit caused Chinese clinical benefits Combination Combinational therapy COVID-19 COVID-19 treatment degranulation demonstrated Endothelial cell English epithelial feasible Histamine histamine receptor hyperinflammation Immune-mediated in vivo Inflammation inflammation-induced lung injury inflammatory disease initiate Injury lAbel loratadine Lung injury lung lesion lung lesions mast cell Mast cells MCs mediator mice off-label off-label use predicted Prevent prevented receptor reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike protein Spike protein suggested suppress Treatment viral replication [DOI] 10.24272/j.issn.2095-8137.2021.469 PMC 바로가기 [Article Type] Article
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine stormFamotidine은 미주 신경 염증 반사를 활성화하여 사이토카인 폭풍을 약화시킵니다.Article Published on 2022-05-162022-09-11 Journal: Molecular Medicine [Category] 유전자 메커니즘, [키워드] Acetylcholine acetylcholine receptor activate Administered Alpha antagonist Anti-inflammatory anti-inflammatory activity anti-inflammatory effect Anti-inflammatory effects antiviral activity attenuate Blood brain barrier Brain cause Central nervous system characterized cholinergic Cholinergic anti-inflammatory pathway Cimetidine Clinical course Clinical studies clinical study Clinical use concentrations COVID-19 Cytokine storm disease dosage dosages Effect Evidence Famotidine Gastroesophageal reflux gastroesophageal reflux disease Genetic Histamine Histamine receptors ICV IL-6 Inflammatory inhibits inflammation knock-out lipopolysaccharide mast cell Mast cells mechanism mechanism of action mice morbidity and mortality Necrosis observation penetrate Prevent pro-inflammatory cytokine pro-inflammatory cytokine release Ranitidine recent receptor reduced released replicated serum severe COVID-19 Signal transduction Signaling significantly significantly more stimulated survival syndrome TNF treat Tumor tumor necrosis tumor necrosis factor vagus nerve Vagus nerve signaling. were assessed while α7nAChR [DOI] 10.1186/s10020-022-00483-8 PMC 바로가기 [Article Type] Article
Effective Anti-SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders클론 비만 세포 장애 환자에서 효과적인 항 SARS-CoV-2 면역 반응Article Published on 2022-05-012022-09-11 Journal: The journal of allergy and clinical immunology. In [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] absence Activation acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immune response anti-SARS-CoV-2 antiviral immune response antiviral immunity B cells Cell cell activation characterized circulating clinical follow-up Clonal mast cell activation syndrome collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Critical disorder ELISA evaluated French hospital Humoral response humoral responses IFN-γ IgA IgG IgGs immune response Innate immunity marker mast cell Mast cell activation disorders Mast cells Mastocytosis mechanical ventilation MOST Neutralizing Neutralizing antibodies noninvasive outcome oxygen Patient patients PCR rare disease required respiratory response risk SARS-CoV-2 Serologically severe coronavirus disease steroid steroid therapy Stimulation syndrome T cell T cells T-cell therapy tryptase Two patient two patients was measured [DOI] 10.1016/j.jaip.2021.12.038 PMC 바로가기 [Article Type] Article
Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patientsSARS-CoV-2에 대한 초기의 강력한 항체 반응은 COVID-19 환자의 질병 중증도를 예측합니다Article Published on 2022-04-152022-09-11 Journal: Journal of Translational Medicine [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료법, [키워드] antibody antibody levels Antibody profile Antibody Response Antibody responses Antibody-dependent enhancement Antigen Antigen microarray Biomarker Candidates cell activation Clinical significance correlated COVID-19 COVID-19 patient disease disease severity elicit epidemiological studies exacerbate frequencies Frequency full length healthy controls idea IgA IgA response IgA responses IgE IgG IgM response IgM responses implication levels of antibody mast cell Mast cells Mild disease MOST nonstructural protein nucleocapsid Pathogenesis pathogenesis of COVID-19 Patient patients with COVID-19 peak levels Planning predict Prevalence Prognosis prognostic Protein recent response Result risk S protein SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens sera serological studies SEROLOGICAL STUDY Serum level severe disease severity Spread Support testing antibody the disease the vaccine vaccine candidates virus with mild disease [DOI] 10.1186/s12967-022-03382-y PMC 바로가기 [Article Type] Article
COVID-19 and Lung Mast Cells: The Kallikrein–Kinin Activation PathwayArticle Published on 2022-02-022022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 activated Activation addition Affect affected alarmin alveolar angiotensin-converting enzyme 2 association Biomarker caspase-1 condition control patients correlation COVID-19 COVID-19 patient COVID-19 patients DAD degranulation Diffuse alveolar damage disease drug edema Effect event events evidenced exacerbated Factor group H1N1pdm09 IgE IL-33 immunoexpression Immunoglobulin increase in Inflammation Inflammatory inhibit interstitial intra-alveolar investigated kallikrein–kinin system (KKS) mast cell mast cells (MCs) MCs outcome Patient perivascular post-mortem lung Prevent Prognosis provided receptor Region responsible SARS-CoV-2 secretion the patient these cell tissue Toluidine Blue Vascular vascular hyperpermeability vascular permeability worsening [DOI] 10.3390/ijms23031714 PMC 바로가기 [Article Type] Article
Hypersensitivity may be involved in severe COVID-19과민증은 심각한 COVID-19에 관련될 수 있습니다Article Published on 2022-02-012022-09-11 Journal: Clinical and experimental allergy : journal of the [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] activated AhR airway analysed anti-SARS-CoV-2 Anti-SARS-CoV-2 specific IgE antibodies cell activation Clinical severity conducted coronavirus disease Coronavirus disease 2019 correlated Corticosteroid Corticosteroids COVID-19 detect Early convalescence endoscopy Evidence evidence of histological hypersensitivity hypersensitivity reactions hypoxemic Hypoxemic respiratory failure IgE IgE-mediated hypersensitivity reactions inflammatory storm intestinal tissues involved lung mast cell Mast cells mechanism Methylprednisolone Methylprednisolone therapy nucleocapsid nucleocapsid protein PaO Pathogenesis positive Protein provocation test pulmonary Pulmonary function test pulse pulse methylprednisolone therapy Respiratory failure S1 protein serum Serum level severe cases severe COVID-19 Severity Score significantly higher [DOI] 10.1111/cea.14023 PMC 바로가기 [Article Type] Article
Transcriptomic Profiling of Mouse Mast Cells upon Pathogenic Avian H5N1 and Pandemic H1N1 Influenza a Virus InfectionArticle Published on 2022-01-292023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] influenza A virus mast cell Nbeal2 Transcriptome [DOI] 10.3390/v14020292 PMC 바로가기 [Article Type] Article
Protocol for the Metformin Aneurysm Trial (MAT): a placebo-controlled randomised trial testing whether metformin reduces the risk of serious complications of abdominal aortic aneurysm메트포르민 동맥류 시험 프로토콜(MAT): 메트포르민이 복부 대동맥류의 심각한 합병증 위험을 감소시키는지 여부를 테스트하는 위약 대조 무작위 시험Study Protocol Published on 2021-12-272022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] Abdominal aortic aneurysm Alpha Aneurysm aneurysms Antibiotics aortic aneurysm Asymptomatic benefit blood pressure cardiovascular event Cell clinical COVID-19 pandemic defined diabetes double-blind drug therapy event events Evidence evidence of growth include inhibitor International life mast cell medication metformin metformin XR Mortality Multiple observational studies observational study outcome overcome parallel-group participant Patient Placebo placebo-controlled placebo-controlled trial potential participant Primary outcome progression proportion Quality of life randomised randomised controlled trial Randomised trial receive reduce reduced required risk rupture secondary Secondary outcomes serious complication single-blind surgical therapy Trial Trial registration trials unique [DOI] 10.1186/s13063-021-05915-0 PMC 바로가기 [Article Type] Study Protocol
SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injurySARS-CoV-2 유발 비만 세포 급속 탈과립은 폐포 상피 염증 및 폐 손상을 유발합니다Article Published on 2021-12-172022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료제, [키워드] ACE-2 ACE2 acute lung injury administration alveolar alveolar epithelial cells binding Cell COVID-19 severity COVID-19 treatments degranulation disrupt epithelial epithelial cells humanized hyper-inflammation hypercytokinemia identifying immune immunomodulator immunomodulators induce Infectious diseases Inflammation initiate initiated Injury lAbel Lung inflammation Lung injury mast cell Mast cells MCs mechanism mediators mice Microbiology mucosa off-label off-label use prevented pro-inflammatory factor pro-inflammatory factors RBD binding reduce regulate rhesus macaques SARS-CoV-2 SARS-COV-2 infection signaling pathway tight junction tight junctions Trigger triggers [DOI] 10.1038/s41392-021-00849-0 PMC 바로가기 [Article Type] Article