Improved methods for the detection and quantification of SARS-CoV-2 RNA in wastewater폐수에서 SARS-CoV-2 RNA의 검출 및 정량화를 위한 개선된 방법Article Published on 2022-05-032022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] aluminum aluminum hydroxide buffer complexity Concentration confirmed cases coronavirus correlation COVID-19 pandemic detect enveloped virus epidemiological data genetic material glycine hydroxide Improved lack matrix mengovirus methodology N1 and N2 organic matter positive Precipitation problems produced quantification quantity reduction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection selected targets virus wastewater [DOI] 10.1038/s41598-022-11187-8 PMC 바로가기 [Article Type] Article
Label-free duplex SAMDI-MS screen reveals novel SARS-CoV-2 3CLpro inhibitors라벨이 없는 이중 SAMDI-MS 화면은 새로운 SARS-CoV-2 3CLpro 억제제를 보여줍니다Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro activities acute respiratory syndrome Analysis Anti-viral Antiviral compound Antiviral compounds assays biochemical assay cathepsin cathepsin L cellular cytotoxicity chymotrypsin completion coronavirus COVID-19 cysteine cysteine protease described dose response evaluated feature gold High-throughput screening Human rhinovirus inhibitor mass mass spectrometry matrix monolayer optimization protease Protease inhibitor Proteases required reveal rhinovirus rhinoviruses SARS-CoV-2 selective selectivity Severe acute respiratory syndrome small molecule specific inhibitor structure activity relationship therapeutic target [DOI] 10.1016/j.antiviral.2022.105279 PMC 바로가기 [Article Type] Article
Biological Matrix Supply Chain Shortages: More Matrices Are Now Rare-the Case for Surrogate MatricesEditorial Published on 2022-03-142022-10-04 Journal: The AAPS Journal [Category] 신약개발, [키워드] addition alleviate Biological Biomarker Biomarkers Cell chain contract research organization COVID-19 COVID-19 pandemic driven by ethical standards Gene therapy immunogenicity implication include instance maintain matrix outlined pandemic pharmacokinetic pharmacokinetics Regulatory Regulatory Authorities regulatory authorities. selected significant delay strained Strains Study protocol subject supply Support surrogate therapeutic unique Vaccine development [DOI] 10.1208/s12248-022-00694-1 PMC 바로가기 [Article Type] Editorial
Diagnostics of SARS-CoV-2 infection using electrical impedance spectroscopy with an immunosensor to detect the spike protein스파이크 단백질을 검출하기 위해 면역 센서와 전기 임피던스 분광법을 사용하여 SARS-CoV-2 감염 진단Article Published on 2022-03-012022-09-11 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] addition antibody Biomarker change chitosan coated with concentrations control sample country COVID-19 detect detection diagnostics electrical electrical impedance genetic material healthy healthy and infected patients Immunosensors impedance Impedance spectroscopy inactivated infected patients Information visualization Interaction limit of detection linear mass matrix mechanism methodology multidimensional performed point-of-care Protein resources SARS-CoV-2 SARS-COV-2 infection selective species spike Spike protein spike protein of SARS-CoV-2 the spike protein virus [DOI] 10.1016/j.talanta.2021.123076 PMC 바로가기 [Article Type] Article
Computational, Experimental, and Clinical Evidence of a Specific but Peculiar Evolutionary Nature of (COVID-19) SARS-CoV-2Review Published on 2022-02-102023-06-16 Journal: Journal of Proteome Research [Category] COVID19(2023년), MERS, SARS, [키워드] antibody attenuate coronavirus COVID disorder immune intrinsic matrix membrane nucleocapsid nucleoprotein omicron pangolin Protein Severe acute respiratory shell Vaccine virulence [DOI] 10.1021/acs.jproteome.2c00001 PMC 바로가기 [Article Type] Review
Evaluation of the Thermo Scientific SureTect Salmonella Species PCR Assay in a Broad Range of Foods and Select Environmental Surfaces: Pre-Collaborative and Collaborative Study: First Action 2021.02광범위한 식품 및 선별된 환경 표면에서 Thermo Scientific SureTect 살모넬라 종 PCR 분석 평가: 사전 협력 및 협력 연구: 첫 번째 조치 2021.02Article Published on 2022-02-042022-09-11 Journal: Journal of AOAC International [Category] SARS, 치료기술, [키워드] Action addition aims Amendment Analysis Applied Biosystem Applied Biosystems BAM comparable conducted Contamination correction COVID-19 pandemic cross-contamination demonstrated Department detection drug Egg Enumeration equivalence Europe evaluated extension false false-negative rate false-negative rates FDA fish food food safety highlighting identification indicate Inspection Laboratory laboratory result Laboratory results manual matrix Microbiology nine participant PCR performed poultry Probability produced product Range Rapid reagent reference method reported reproducibility robustness Safety Salmonella serotyping service Specy Sponge statistical analysis statistical model status tested the United State Thermo Thermo Scientific thermocycler thermocyclers United States US Food and Drug Administration [DOI] 10.1093/jaoacint/qsab122 PMC 바로가기 [Article Type] Article
COVID-19, sex, and gender in China: a scoping reviewResearch Published on 2022-02-042022-11-01 Journal: Globalization and Health [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] absence Affect affected Analysis assist Care China Chinese conducted contribute country Course COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 testing deaths effective English language exclusion Factors first stage Gender Gendered impacts health emergency healthcare Hospital admissions Impact Infection infection rates Infectious disease knowledge literature review lockdown matrix mental health outbreak peer-reviewed populations pregnant public health measures real time Research Result risk Sex Sex-disaggregated data supplementary material toolkit Treatment women World Health Organization [DOI] 10.1186/s12992-022-00804-w PMC 바로가기 [Article Type] Research
Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patientsCOVID-19 환자의 중증도 바이오마커로서의 기질 금속단백분해효소(MMP) 3 및 9Clinical Trial Published on 2022-01-242022-09-10 Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, 치료법, [키워드] benefit Biomarker Biomarkers circulating neutrophil circulating neutrophils clinical heterogeneity contribute controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity disease severity Diseases Health Organization help Hospital admission Hospitalization hospitalized patient immunology inflammatory process interleukin-6 lung damage Lung inflammation matrix matrix metalloproteinases Medical research metalloproteinase MMP3 MMP9 molecular basis monocyte Monocytes myeloperoxidase Neutrophils no correlation occur pathogenic positively correlated Potential biomarker potential biomarkers predict progression Protein Proteins regeneration serum Serum level serum levels severe COVID-19 patient severe COVID-19 patients severe patients severity severity of COVID-19 significantly increased targeted therapy the WHO to define was increased was reduced WHO World Health Organization [DOI] 10.1038/s41598-021-04677-8 PMC 바로가기 [Article Type] Clinical Trial
Effects of Vitamin D and K on Interleukin-6 in COVID-19Nutrition Published on 2022-01-172022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] 25-hydroxyvitamin D administration arise association Biomarker circulating Clinical outcome clinical outcomes Combination correlated COVID-19 COVID-19 infection COVID-19 patients Degradation desmosine disease dp-ucMGP Effect excessive inflammatory response fiber hospitalized COVID-19 patient IL-6 IL-6 level IL-6 levels IMPROVE Inflammatory Inflammatory response Intervention matrix not significantly different outcome Patient Result significantly higher statistically significant Trial Vitamin D vitamin K [DOI] 10.3389/fnut.2021.761191 PMC 바로가기 [Article Type] Nutrition
FMD-Yolo: An efficient face mask detection method for COVID-19 prevention and control in publicResearch article Published on 2022-01-012022-10-05 Journal: Image and Vision Computing [Category] 치료기술, [키워드] Accuracy adopted aggregation Algorithms applied Convolution Coronavirus disease 2019 COVID-19 database datasets detection efficiency disease effective eight Epidemic Face mask face mask detection Feature extraction and fusion Hierarchical IMPROVE Improved YoloV3 algorithm information Mask matrix mechanism MONITOR NMS performed Precision virus transmission [DOI] 10.1016/j.imavis.2021.104341 [Article Type] Research article