Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging VariantsArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, [키워드] acidic pH airway Airway organoids Cell cellular ciliary ciliary damage ciliated cell Culture Delta Efficiency generate higher infectivity Human imperative in vitro model Infection Infectivity Interaction maturation Model monolayer morphologically nasal nasal epithelial cell nasal epithelium nasal organoids nasopharyngeal omicron Organoid Primary infection protocol remained replicative fitness respiratory respiratory viruses robust SARS-CoV-2 tight junction. tight junctions Transmissibility Transmission upper upper respiratory infection upper respiratory tract variant variants viral pathogenesis virus spread [DOI] 10.1128/mbio.01944-22 PMC 바로가기
How does age determine the development of human immune-mediated arthritis? Reviews Published on 2022-08-102022-10-05 Journal: Nature reviews. Rheumatology [Category] 유전자 메커니즘, 진단, [키워드] Adults Affect age Arthritis autoantibody children chronic inflammation contribute controls Critical determine develop disease driven by Drivers environmental exposure Epigenetic expand facilitate Factor Factors Genetic genetics hypothese immune immune system immune tolerance Immune-mediated individual Inflammation involved juvenile idiopathic arthritis maturation mechanism mechanisms microbial modulation Numerous Pathogenesis Patient Phenotypes pro-inflammatory similarity tolerogenic [DOI] 10.1038/s41584-022-00814-3 [Article Type] Reviews
Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA.1, BA.2 and BA.3 following third mRNA vaccination세 번째 mRNA 백신 접종 후 SARS-CoV-2 Omicron BA.1, BA.2 및 BA.3의 항체 친화도 및 교차 변이체 중화Article Published on 2022-08-082022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] addition Adults Affinity maturation antibody antibody affinity Antibody binding booster vaccination booster vaccinations breadth convalescent individual convalescent individuals cross-reactive antibody develop dose effective high affinity immune Immunity individual knowledge maturation mRNA vaccination mRNA vaccine naïve naïve individuals neutralization neutralization activity neutralization capacity neutralization titer omicron Pseudovirus neutralization assay PsVNA resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Spike protein Spike proteins spikes SPR Support surface plasmon surface plasmon resonance vaccination WA1 [DOI] 10.1038/s41467-022-32298-w PMC 바로가기 [Article Type] Article
Microneedle-based two-step transdermal delivery of Langerhans cell-targeting immunoliposomes induces a Th1-biased immune responseLangerhans 세포 표적 면역리포좀의 미세바늘 기반 2단계 경피 전달은 Th1 편향 면역 반응을 유도합니다Article Published on 2022-08-012022-09-12 Journal: European journal of pharmaceutics and biopharmaceu [Category] MERS, 진단, [키워드] activate affecting antibody Antigen Antigen presentation CD11c Cellular immune response Combination Compliance DCs dendritic cell effective Efficiency expected immune immune response immunization Immunoliposomes IMPROVE in vivo indicated induce inhibit Langerhans cell Langerhans cell targeting Liposome maturation Microneedle monoclonal monoclonal antibody novel produced promoted significantly stimulated survival Th1-biased immune response the epidemic Transcutaneous Transcutaneous immunization. tumor growth Vaccine [DOI] 10.1016/j.ejpb.2022.06.004 PMC 바로가기 [Article Type] Article
BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults이종 프라임-부스트 백신 접종 후 BNT162b2 부스터는 젊은 성인에서 SARS-CoV-2 Omicron BA.1에 대한 강력한 중화 항체 및 T 세포 반응성을 유도합니다Article Published on 2022-07-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adults analysed Antibody titer Antibody titers B.1 B.1.1.529.1 BA.1 BNT162b2 booster Cell cellular immunity ChAdOx1 ChAdOx1 nCoV-19 Cohort Course COVID-19 defined Delta dominant Effect effective elicited Epitopes Heterologous heterologous prime-boost humoral humoral and cellular immunity Humoral immunity immune immune protection immune responses Immunity individual induce initial interval maturation memory T memory T cell memory T cells nCoV neutralization titer neutralization titers neutralized Neutralizing activity neutralizing antibody omicron performed reactivity residual responses against resulting SARS-CoV-2 SARS-COV-2 infection spike epitope spike epitopes subsequent symptomatic SARS-CoV-2 infection T cell T cells the early SARS-CoV-2 vaccination vaccination interval. Vaccinations variant variants variants of concern VOCs [DOI] 10.3389/fimmu.2022.882918 PMC 바로가기 [Article Type] Article
Dual Inhibition of Vacuolar-ATPase and TMPRSS2 Is Required for Complete Blockade of SARS-CoV-2 Entry into CellsSARS-CoV-2 세포로의 진입을 완전히 차단하려면 Vacuolar-ATPase 및 TMPRSS2의 이중 억제가 필요합니다Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ATPase bafilomycin block viral entry camostat cathepsin inhibitor Cathepsins Cell cellular Compound coronavirus E64d Efficacy endosomal pH endosomal protease endosome expressing highlight host cell host protease host proteases Hydroxychloroquine identify implicated Infection inhibit inhibiting inhibition inhibitor inhibitors Intervention life cycle Macrolide maturation mechanisms membrane fusion molecules Neutralizing nonspecific Pathways pharmacological agent Prevent protease Protein proteolytic activation provide pseudotyped rationale S protein SARS SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine serine 2 serine proteases severe acute respiratory syndrome Coronavirus synergy the S protein these compound these compounds TMPRSS2 TMPRSS2 inhibitor TMPRSS2-expressing cells toxicities Toxicity transmembrane V-ATPase viral entry viral spike virus virus. [DOI] 10.1128/aac.00439-22 PMC 바로가기 [Article Type] Article
Hepatitis C virus NS3/4A inhibitors and other drug-like compounds as covalent binders of SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제의 공유 결합제로서의 C형 간염 바이러스 NS3/4A 억제제 및 기타 약물 유사 화합물Article Published on 2022-07-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro active site Antiviral antiviral inhibitor approved binding catalytic cause clinical trials clinically Compound compounds coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics Cys145 derivative derivatives drug drug target Evidence global public health hepatitis C hepatitis C virus higher affinity inhibitor M pro maturation molecular docking studies Molecular docking study pandemic polyproteins protease Protein residue SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 main protease Severe acute respiratory syndrome Spread the SARS-CoV-2 genome Vaccine variants virus [DOI] 10.1038/s41598-022-15930-z PMC 바로가기 [Article Type] Article
Targeting TFH cells in human diseases and vaccination: rationale and practice Reviews Published on 2022-07-112022-10-05 Journal: Nature Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] allergens antibody antibody affinity Antigen approach Autoantigens B cell B cells boost CD4+ T cell Cell cytokine disease disease pathogenesis Efficacy facilitate human disease Humoral immunity Infection knowledge lymphomagenesis maturation mechanisms memory pathogen clearance pathogenic protective antibody response receptor regulate Regulation reservoirs response Support survival T cell targeting TCR therapy Vaccine [DOI] 10.1038/s41590-022-01253-8 [Article Type] Reviews
Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatmentResearch article Published on 2022-07-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] Activation acute respiratory syndrome Analysis analyzed Anti-inflammatory therapy apoptotic ASC Blood cDNA cell line circulating monocyte circulating monocytes coding confocal microscopy coronavirus COVID-19 Critically ill cytokine cytokine secretion Cytokine storm syndrome disease dissect driving effective Efficacy Evidence Frame IL-1 receptor antagonist IL-1β in vitro Infection Inflammasome inflammasomes Inflammation Inflammatory inflammatory parameters manifestation maturation mechanism NLRP3 NLRP3 inflammasome objective ORF3a pathway Patient patients with COVID-19 Phenotypes Plasma cytokine receptor protein reducing mortality regulated respond Result RNA sequencing SARS-CoV-2 SARS-CoV-2 protein secrete secretion severe coronavirus disease severe COVID-19 patient severe pneumonia shown Spontaneous transfection Treatment Trigger with COVID-19 [DOI] 10.1016/j.jaci.2022.05.029 [Article Type] Research article
Ligand-based and structure-based studies to develop predictive models for SARS-CoV-2 main protease inhibitors through the 3d-qsar.com portal3d-qsar.com 포털을 통해 SARS-CoV-2 주요 프로테아제 억제제에 대한 예측 모델을 개발하기 위한 리간드 기반 및 구조 기반 연구Article Published on 2022-07-012022-09-11 Journal: Journal of computer-aided molecular design [Category] COVID19(2023년), SARS, 치료제, [키워드] 3-D QSAR Analysis applicability approach binding binding energy build calculation Candidates cleavage site co-crystallized Combination COMBINE Compound conservation coronavirus COVID-19 infected patients develop domain drug design Emergency use authorization enzyme EUA feature Final functional protein implicated in viral inhibitor inhibitors joint Ligand ligand-based drug design M pro maturation Metrics Mild-to-moderate Model molecular Nirmatrelvir outcome performed portal Predictive Predictive model promote protease Quantitative reached Replication reported resources robust robustness safety profile SARS-CoV-2 SARS-CoV-2 main protease statistical Structure-activity relationships structure-based drug design. tolerable training set Transcription Treatment U.S. FDA viral replication Virtual screening [DOI] 10.1007/s10822-022-00460-7 PMC 바로가기 [Article Type] Article