Inhaled pulmonary vasodilators are not associated with improved gas exchange in mechanically ventilated patients with COVID-19: A retrospective cohort studyObservational Study Published on 2022-06-012022-10-05 Journal: Journal of critical care [Category] 임상, [키워드] 95% CI ARDS COVID-19 Effect Epoprostenol FIVE fixed Gas exchange index Inhaled Inhaled nitric oxide measure mechanically ventilated mechanically ventilated patient nasopharyngeal New York nine nitric oxide Observational cohort study Oxygenation Patient patients PCR positive Primary outcome respiratory Respiratory failure retrospective retrospective cohort study significantly treated university ventilatory Ventilatory ratio was performed with COVID-19 [DOI] 10.1016/j.jcrc.2022.153990 PMC 바로가기 [Article Type] Observational Study
The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infectionSARS-CoV-2 감염이 있는 기계 환기 환자의 내피 활성화 및 손상 마커에 대한 프로스타사이클린 주입의 효과Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: Journal of critical care [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] Activation Adult patients baseline Biomarker Biomarkers blood sample Blood samples CD40L change changes in collected COVID-19 damage decrease endothelial Endothelium glycocalyx groups marker mechanically ventilated mechanically ventilated patient mechanically ventilated patients median medians not differ Organ failure P-selectin Patient pilot study Placebo placebo group plasma Plasma levels prostacyclin protective effect Randomized Randomized controlled trial reduction in SARS-CoV-2 SARS-COV-2 infection selectin significantly syndecan Syndecan-1 the placebo group thrombomodulin with COVID-19 [DOI] 10.1016/j.jcrc.2022.154010 PMC 바로가기 [Article Type] Randomized Controlled Trial
Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndromeObservational Study Published on 2022-05-232022-10-05 Journal: Critical Care [Category] 임상, [키워드] acute respiratory distress adjusted Analysis ARDS Bilirubin Chemical Chemical and drug-induced liver injury Cholangiopathy Cholangitis cholestasis competing confidence interval COVID-19 patient COVID-19 patients COVID-19-associated ARDS Critically ill Critically ill patient cumulative doses High-dose Hypnotics and sedatives. ICU incidence infused Ketamine liver Liver injury mechanically ventilated mechanically ventilated patient mixed-effects model multivariable Patient positively correlated post-hoc analysis propofol prospective observational cohort receiving regimen rising risk Sedation shown syndrome total bilirubin [DOI] 10.1186/s13054-022-04019-8 PMC 바로가기 [Article Type] Observational Study
Study protocol to test the efficacy of self-administration of dexmedetomidine sedative therapy on anxiety, delirium, and ventilator days in critically ill mechanically ventilated patients: an open-label randomized clinical trial중환자 기계 환기 환자의 불안, 섬망 및 인공 호흡기 일에 대한 덱스메데토미딘 진정 요법의 자가 투여 효과를 테스트하기 위한 연구 프로토콜: 공개 라벨 무작위 임상 시험Article Published on 2022-05-162022-09-11 Journal: Trials [Category] 임상, [키워드] addition aggregate alertness alleviate alteration Anxiety approach approaches assigned Care change clinical Clinical practice clinical trial Consistency Course COVID-19 case COVID-19 pandemic Critically ill delirium Depression dexmedetomidine distress Efficacy eligible Eligible participants eligible patient Eligible patients enrolment equipment extubation finding flexible functional Functional status healthcare ICU ICU care ICU patient ICU Patients identify impacted imperative intensive care intensive care unit life management Mechanical mechanical ventilation mechanical ventilatory support mechanically ventilated mechanically ventilated patient mechanically ventilated patients medication Open-label opioid outcome Oxygenation Pain Patient patient symptom Patient symptoms physical Post-traumatic stress disorder Protective protocol Psychological well-being Quality of life randomization Randomized randomized clinical trial Randomly receiving recruitment Secondary objective Secondary objectives Sedation sedative Self-management Side effects significantly study population subset Symptom therapy Trial trial enrolment usual care ventilator ventilator-free day Ventilator-free days ventilatory support [DOI] 10.1186/s13063-022-06391-w PMC 바로가기 [Article Type] Article
Prevalence of post-intensive care syndrome in mechanically ventilated patients with COVID-19Observational Study Published on 2022-05-132022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료법, [키워드] acute respiratory syndrome added age Anxiety Care clinics cognitive Cohort Comorbidity conducted coronavirus coronavirus disease 19 COVID-19 criteria Critical damaged delirium Depression determine disorder domain evaluated Follow-up form functional HADS hospital hospital discharge ICU intensive care Invasive mechanical ventilation IQR mechanical ventilation mechanically ventilated patient median men mental health disorders Muscle strength Patient patients performed physical Posttraumatic Stress predisposition Prevalence psychiatric disorder Psychiatric disorders Psychological pulmonary Pulmonary function SARS-CoV-2 SARS-COV-2 infection Sedation sick subsequent survey survived survivor symptom severity syndrome therapy weakness with COVID-19 [DOI] 10.1038/s41598-022-11929-8 PMC 바로가기 [Article Type] Observational Study
Low phase angle is associated with 60-day mortality in critically ill patients with COVID-19낮은 위상각은 COVID-19 중환자의 60일 사망률과 관련이 있습니다.Article Published on 2022-05-012022-09-11 Journal: JPEN. Journal of parenteral and enteral nutrition [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus Admission Analysis association bioelectrical impedance Bioelectrical Impedance Analysis biological marker body composition body water clinical outcomes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill Critically ill patient critically ill patients Cutoff death Extracellular female hazard ratio Hospital stay increased risk intensive care intensive care unit admission Kaplan-Meier curves Linear regression model male Malnutrition mechanical ventilation mechanically ventilated patient mechanically ventilated patients Mortality mortality risk nutrition risk nutrition status Odds ratio on mechanical ventilation parameter Pathologies Patient Phase angle predictor prospective cohort risk Risk assessment SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly increased survival analysis variable was performed water were used with COVID-19 [DOI] 10.1002/jpen.2236 PMC 바로가기 [Article Type] Article
Programmed multi-level ventilation in COVID-19-related acute respiratory distress syndrome: a multi-center retrospective observational studyObservational Study Published on 2022-05-012022-10-04 Journal: The Journal of international medical research [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome Admission adverse events analyzed appear approach ARDS conducted coronavirus disease Coronavirus disease 2019 distress effective evaluated expiratory fraction Hypoxemia Intensive intensive care interquartile range mechanical ventilation mechanically ventilated patient median multicenter non-survivor outcome oxygen oxygen saturation Oxygenation Patient patients patients treated positive programmed multi-level ventilation Respiratory failure retrospective Retrospective study Safe stability survivor syndrome ventilated patient Ventilation ventilatory was used [DOI] 10.1177/03000605221101970 PMC 바로가기 [Article Type] Observational Study
Serial Assessment of Myocardial Injury Markers in Mechanically Ventilated Patients With SARS-CoV-2 (from the Prospective MaastrICCht Cohort)SARS-CoV-2가 있는 기계 환기 환자의 심근 손상 표지자에 대한 연속 평가(예상 MaastrICCht 코호트에서)Article Published on 2022-05-012022-09-11 Journal: The American journal of cardiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Abnormalities abnormality Admission age APACHE assessment baseline both group both groups cardiac troponin Characteristics Cohort collected Concentration Course COVID COVID-19 creatinine cTnT diabetes Diabetes Mellitus Electrocardiograms electrocardiographic Gender hypertension in-hospital mortality Injury intensive care intensive care unit intensive care unit admission mechanically ventilated mechanically ventilated patient mechanically ventilated patients Mortality myocardial injury N-terminal N-terminal pro-B-type natriuretic peptide nonsurvivor nonsurvivors not differ NT-proBNP obesity outcome patients patients with COVID-19 peptide pro-B-type natriuretic peptide Prospective SARS-CoV-2 significant difference significant differences survivor troponin T was used were assessed with COVID-19 [DOI] 10.1016/j.amjcard.2022.01.030 PMC 바로가기 [Article Type] Article
Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections Research Published on 2022-03-092022-10-05 Journal: Nature Communications [Category] 변종, 진단, [키워드] Administered Amplicon sequencing analyzed antibiotic Antibiotic resistance Antibiotic therapy Bacterial infection bacterial respiratory infection changes changes in clinically collected Cycling driving early stage Effect Evolution Frequency genomic in vivo frequency Infection isolate mechanically ventilated patient Mutation Patient Population Pseudomonas aeruginosa Rapid resistance to antibiotics respiratory infection Sequencing Sputum sample Surveillance switching therapy treated Treatment [DOI] 10.1038/s41467-022-28188-w [Article Type] Research
Potential for the lung recruitment and the risk of lung overdistension during 21 days of mechanical ventilation in patients with COVID-19 after noninvasive ventilation failure: the COVID-VENT observational trialObservational Study Published on 2022-03-042022-10-04 Journal: BMC Anesthesiology [Category] MERS, SARS, 임상, [키워드] acute respiratory distress syndrome alveolar calculated Compliance Course COVID-19 Critically ill Day dead driving Gas exchange highest improvement intensive care unit lowest lung Lung recruitability lung recruitment Lung strain mechanical ventilation mechanically ventilated patient non-survivor Noninvasive ventilation occurred PaO Patient patients PEEP Positive end-expiratory pressure Potential primary endpoint prospective observational study Recruitability recruitment Registered Respiratory failure Respiratory mechanics Respiratory system Result risk significant decrease supplementary material survivor Survivors the disease Trial university ventilatory Volume Volutrauma with COVID-19 [DOI] 10.1186/s12871-022-01600-0 PMC 바로가기 [Article Type] Observational Study