Searching for target-specific and multi-targeting organics for Covid-19 in the Drugbank database with a double scoring approachArticle Published on 2020-11-052022-10-04 Journal: Scientific Reports [Category] 신약개발, 임상, 진단, 치료제, [키워드] 3CLpro active against addition adopted approach approach AutoDock baloxavir marboxil bind binding binding affinity binding energy binding free energy clinical trial Compound coronavirus crystal structure darunavir database death dihydroergotamine Drug discovery drug trials drugs healthcare help homology host cell identify Infection inhibit lack Lonafarnib Medicinal chemistry molecular Nilotinib outbreak pandemic Papain-like protease phthalocyanine PLPro protease Protein RdRP reached reported Research RNA-dependent RNA polymerase SARS-CoV-2 screened Spike protein Spread Structure Tadalafil target targets Theoretical chemistry these compounds Treatment viral infection virus [DOI] 10.1038/s41598-020-75762-7 PMC 바로가기 [Article Type] Article
Druggable targets from coronaviruses for designing new antiviral drugsArticle Published on 2020-09-082023-07-01 Journal: Bioorganic & Medicinal Chemistry [Category] SARS, [키워드] Medicinal chemistry MERS-CoV Molecular modeling SARS-CoV SARS-CoV-2 [DOI] 10.1016/j.bmc.2020.115745 PMC 바로가기 [Article Type] Article
Discovery and optimizing polycyclic pyridone compounds as anti-HBV agentsReview Published on 2020-09-012023-06-11 Journal: Expert opinion on therapeutic patents [Category] B형 간염, [키워드] drug design HBV inhibitors High-throughput screening hit-to-lead optimization Medicinal chemistry Polycyclic pyridone scaffold hopping. [DOI] 10.1080/13543776.2020.1801641 PMC 바로가기 [Article Type] Review
Promising inhibitors targeting M pro : an ideal strategy for anti-SARS-CoV-2 drug discoveryResearch Highlight Published on 2020-08-272022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 치료제, [키워드] anti-SARS-CoV-2 Drug discovery Infectious diseases inhibitor M pro Medicinal chemistry [DOI] 10.1038/s41392-020-00291-8 PMC 바로가기 [Article Type] Research Highlight
On Facing the SARS-CoV-2 (COVID-19) with Combination of Nanomaterials and Medicine: Possible Strategies and First ChallengesReview Published on 2020-04-282022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] acute respiratory syndrome approved Care challenge China coronavirus Coronavirus-2 COVID-19 COVID-19 pandemic death develop drug drug design effective Health infected individual medical need Medicinal chemistry Nanomaterial pathogen Pneumonia public health Repurposed drugs Research SARS-CoV-2 SARS-CoV-2 virus Strategy the disease the SARS-CoV-2 the SARS-CoV-2 virus theranostic strategies Vaccine virus Wuhan [DOI] 10.3390/nano10050852 PMC 바로가기 [Article Type] Review