Fluorescent nanodiamond-based spin-enhanced lateral flow immunoassay for detection of SARS-CoV-2 nucleocapsid protein and spike protein from different variantsArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] anti-S IgG antibody Antigen antigens B.1.1.529 B.1.1.7 B.1.617.2 binding can be used comparable COVID-19 COVID-19 pandemic current Delta demonstrated Detection limit Diagnosis diagnostic Direct dropped ELISA finding Flow fluorescent Fluorescent nanodiamond incubated Infectious disease Laboratory Lateral lateral flow immunoassay limitations membrane mutations NC membrane nonspecific omicron platform Protein public health Quantitative reporter responsible S proteins SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SELFIA. Spike protein suggested the SARS-CoV-2 turnaround times variant variants viruses was performed wild-type Wuhan-1 [DOI] 10.1016/j.aca.2022.340389 PMC 바로가기
Serum angiotensin-converting enzyme 2 as a potential biomarker for SARS-CoV-2 infection and vaccine efficacyArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 angiotensin-converting enzyme 2 Biomarker change changes in circulating cleaved COVID-19 death declined demonstrated Disease progression dose Efficacy elevated expressing full-length highlight host cell receptor human ACE2 humans immunization increase in K18-hACE2 mice membrane mice MVA-S vaccine prevented Proteolytic processing receptor SARS-CoV-2 SARS-COV-2 infection serum serum sample serum. subsequent susceptible the SARS-CoV-2 transgenic vaccination Vaccine vaccine candidate virus virus entry [DOI] 10.3389/fimmu.2022.1001951 PMC 바로가기
Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteasesSARS-CoV-2 주요 및 뎅기 바이러스 프로테아제에 대한 강력한 벤족사보롤 억제제의 발견Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral agent Antiviral agents biochemical assay Cell Cell culture class contribute cytotoxicity demonstrated Dengue dengue virus DENV-2 Drug development evaluated had no Health inhibit inhibitor M pro membrane MOST penetration protease Proteases Replication RNA virus RNA viruses SARS-CoV-2 stability synthesis target targets [DOI] 10.1016/j.ejmech.2022.114585 PMC 바로가기 [Article Type] Article
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike proteinArticle Published on 2022-10-042022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome affected Antiviral assays coronavirus coronavirus disease epitope glycoprotein heptad repeat host cell HR2 include inhibit inhibitor interact interfere less membrane membrane fusion Modification monoclonal antibody Mutation N-terminal offer peptide Peptide Inhibitors peptide. peptides performed Protein Receptor binding domain Region related viruses S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Support target the S protein the SARS-CoV-2 the spike protein therapy Vaccine variants viral entry viral membrane viral spike virus infection [DOI] 10.1073/pnas.2210990119 PMC 바로가기
A ubiquitous bone marrow reservoir of preexisting SARS-CoV-2-reactive memory CD4+ T lymphocytes in unexposed individualsArticle Published on 2022-10-042022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] analyzed Blood bone Bone marrow CD4 CD4+ CD4+ T lymphocyte CD69 Cell central memory circulating contribute COVID-19 cross-reactive described detectable Efficacy Express human bone marrow immune response Immunity individual investigated long-lasting membrane memory memory CD4+ T lymphocytes memory T cell nucleocapsid protein peptide Peripheral blood phenotype Plasma cells polyfunctional Primary infection provided SARS-CoV-2 systemic immune response T cell T cells the vaccine tissue-resident memory T cells (Trm). vaccination Vaccines [DOI] 10.3389/fimmu.2022.1004656 PMC 바로가기
Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Biochimie [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Admission association Biomarker circulating Comorbidities Course COVID-19 COVID-19 patient COVID-19 patients D-dimer Diabetes Mellitus disease disease severity early phase effective ELISA healthy controls host receptor hypertension increase in Infection investigated involved marker membrane moderate outcome plasma Plasma level positive correlation sACE2 sACE2. SARS-CoV-2 Severe case shown significant increase soluble ACE2 the SARS-CoV-2 was determined was obtained was performed [DOI] 10.1016/j.biochi.2022.06.005 PMC 바로가기
Recent advances in aqueous virus removal technologies수성 바이러스 제거 기술의 최근 발전Review Published on 2022-10-012022-09-11 Journal: Chemosphere [Category] 치료기술, [키워드] biochemical Combination COVID-19 outbreak Diseases Disinfection dissemination effective function functions health authorities Health authority membrane outbreak parameter recent reduce Research Spread synergistic Treatment triggered understanding virus virus Virus removal wastewater wastewater treatment. water [DOI] 10.1016/j.chemosphere.2022.135441 PMC 바로가기 [Article Type] Review
Tracheitis Diagnosed With 68 Ga-PSMA PET/CT in a Patient With COVID-19Article Published on 2022-10-012022-11-15 Journal: Clinical nuclear medicine [Category] 바이오마커, [키워드] Antigen Asymptomatic coronavirus disease COVID-19 diagnosed lung membrane Patient PET/CT Pneumonia polymerase chain Prostate cancer Symptom [DOI] 10.1097/RLU.0000000000004288 PMC 바로가기
Extracorporeal membrane oxygenation for respiratory failure in phases of COVID-19 variantsArticle Published on 2022-10-012022-11-16 Journal: Journal of cardiac surgery [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory distress acute respiratory distress syndrome, extracorporeal membrane oxygenation affected age average circulatory support. coronavirus coronavirus disease COVID-19 Delta delta variant demographics discharge ECMO Extracorporeal extracorporeal membrane oxygenation Healthcare system Hispanic hospital ICU in-hospital mortality intensive care Intervention laboratory-confirmed SARS-CoV-2 infection later phase LOS male membrane Most patient Mutation no significant difference outcome Oxygenation pandemic Patient patients who survived predominant Prevalence random Respiratory failure SARS-CoV-2 Severe respiratory distress Support supported survival syndrome variant variants Viral genome sequencing virus white [DOI] 10.1111/jocs.16563 PMC 바로가기
Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligandsArticle Published on 2022-10-012022-11-15 Journal: Febs Letters [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity antiviral therapeutics bind Cell complexes Compound cytotoxicity drug delivery enveloped virus fatty Fatty acid hydrophobic inhibitors Ligand ligands lipid-binding protein mechanism membrane membrane disruption. membranes modulated neutralize Protein replaced resulting SARS-CoV-2 Therapeutic compounds unsaturated viruses [DOI] 10.1002/1873-3468.14456 PMC 바로가기