COVID-19 Pandemic and Patients with Rare Inherited Metabolic Disorders and Rare Autoinflammatory Diseases—Organizational Challenges from the Point of View of Healthcare ProvidersArticle Published on 2021-10-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] administration autoinflammatory disease Care challenge complications coronavirus COVID-19 COVID-19 pandemic died Epidemic health care providers Healthcare provider hospital hospitals impacted implementation Infection Inherited metabolic disorders maintain majority metabolic metabolic disorder mild symptoms pandemic Patient patients Point Poland rare autoinflammatory diseases Responder suffered survey therapy Treatment View vulnerable patient [DOI] 10.3390/jcm10214862 PMC 바로가기 [Article Type] Article
Immunometabolic Dysregulation at the Intersection of Obesity and COVID-19Immunology Published on 2021-10-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute infection association cardiovascular disease Chronic kidney disease clinical study Comorbidity Complication Course COVID-19 COVID-19 progression develop diabetes Diabetes Mellitus disorder dysregulation example higher risk Host hypertension immune response immunometabolism immunopathy individual Intervention Kidney disease Meta-analysis metabolic disorder obese obesity pandemic patient cohort Prognosis recent variety viral infection [DOI] 10.3389/fimmu.2021.732913 PMC 바로가기 [Article Type] Immunology
COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral CenterArticle Published on 2021-09-062022-10-31 Journal: Children [Category] COVID-19, [키워드] Adults Asymptomatic center children Clinical course cohort of patient comparable Control control group COVID-19 COVID-19 pandemic died experience General population hospital Hospitalization incidence of COVID-19 Inherited metabolic disorders involved large cohort management median age metabolic metabolic disorder Mild moderate Patient positive potential risk proportion rare diseases Referral required SARS-CoV-2 single-center source of infection symptomatic case tested treated understanding unmet need [DOI] 10.3390/children8090781 PMC 바로가기 [Article Type] Article
Study protocol: long-term effect of the New Nordic Renal Diet on phosphorus and lipid homeostasis in patients with chronic kidney disease, stages 3 and 4: a randomised controlled trial연구 프로토콜: 만성 신장 질환 환자의 인 및 지질 항상성에 대한 New Nordic Renal Diet의 장기 효과, 3단계 및 4단계: 무작위 대조 시험Article Published on 2021-08-302022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] allergies approach approved assigned baseline Biochemistry Blood blood pressure body composition both groups Breast feeding Capital Capital Region cause changes in chronic Chronic kidney disease chronic renal failure CKD Committee control group criteria criterion Denmark Department diet dietetics Effect Ethics exclusion criteria filtration rate Follow-up food allergies food allergy glomerular filtration rate hypertension in both groups include Inclusion International Intervention Kidney disease law life lipid disorders lipid homeostasis lipid metabolism metabolic disorder Metabolic disorders metabolism National Nephrology New nutrition nutrition & observation period offer outcome outpatient clinic parameter Patient patients with moderate peer-reviewed phosphate phosphorus Pregnancy Primary outcome protection protocol Quality of life randomised controlled trial Randomly recruited reduction in Region registration number registry Regulation renal renal failure Research secondary Secondary outcomes Seven Stage Standard study groups Study protocol study visit submitted telephone consultation Treatment Trial university Urine Version [DOI] 10.1136/bmjopen-2020-045754 PMC 바로가기 [Article Type] Article
Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risksReview Published on 2021-08-032022-10-31 Journal: The EPMA Journal [Category] COVID-19, [키워드] affected aggression Anti-inflammation, Antibacterial Anti-inflammatory antioxidant antiviral properties Antiviral, COVID-19 applied ARDS Cancer Cancer, Chronic diseases Care chronic inflammation clinical utility Complication Coumarins COVID-19 COVID-19 infection Cytokine storm disease disease management Diseases disorder Effect effective Evidence flavonoids Health health condition Health economy Health policy healthcare Immunity individual Inflammation Isolation life-threatening lung damage Mental metabolic disorder mitigate neurologic obesity pandemic Pathologies Patient Periodontitis Personalized medicine phenolic acids Phenolic compounds phytochemicals Predictive Predictive preventive personalized medicine (3PM/PPPM) PROTECT reflected risk Risk assessment signaling pathways sleep quality smoking stilbenoids Stratification subgroup Support targeting Therapy efficacy vascular dysfunction [DOI] 10.1007/s13167-021-00249-y PMC 바로가기 [Article Type] Review
Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes인도 인구 게놈에서 코로나19 치료제의 약리유전체학적 풍경Article Published on 2021-07-012022-09-11 Journal: Pharmacogenomics [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] ABCB1 ALB analyzed candidate clinical decision clinically COVID-19 COVID-19 therapeutics covid-19 therapies COVID-19 therapy COVID-19 treatment CYP3A4 Deleterious drug drug-drug interaction Drug–drug interactions drug–drug–gene interactions drugs Evidence Genome Indian population individual inhibitor Interaction material metabolic disorder Numerous overlapped Patient pharmacogenetic pharmacogenomics pharmacogenomics. populations predicted therapy Treatment validation study variant variants whole genome whole genomes with COVID-19 [DOI] 10.2217/pgs-2021-0028 PMC 바로가기 [Article Type] Article
The Relevance of Plant-Derived Se Compounds to Human Health in the SARS-CoV-2 (COVID-19) Pandemic EraReview Published on 2021-06-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] absorbed accumulated addition Adequate antioxidant catalytic activity catalytic center caused Cell complementary Compound country COVID-19 dietary drug ENhance Epidemic Features Frequency Health Human immune system Impact inorganic insertion mechanism metabolic disorder metabolism metal ions Mutation normal physiological processes Novel coronavirus nucleophilic organic Se oxidants pharmacological plant plant-selenium compounds Population Protein reduce Relevance SARS-CoV-2 selenite Selenoproteins the SARS-CoV-2 Treatment Vaccine viral infections Viral load [DOI] 10.3390/antiox10071031 PMC 바로가기 [Article Type] Review
Dyslipidemia Is Related to Mortality in Critical Patients With Coronavirus Disease 2019: A Retrospective StudyEndocrinology Published on 2021-06-232022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] Admission Clinical outcome collected coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 Critical critical patient critical patients Diseases dyslipidemia hospital ICU intensive care Lipid lipid metabolism Liver function low density lipoprotein Lower metabolic disorder Mortality multiple organ dysfunction parameter Patient patients with COVID-19 profiles Prognosis progression remained renal function reported Result Retrospective study risk factor statistically suffered Total cholesterol treated was performed was related Wuhan Wuhan, China [DOI] 10.3389/fendo.2021.611526 PMC 바로가기 [Article Type] Endocrinology
Abnormal Coagulation Function of Patients With COVID-19 Is Significantly Related to Hypocalcemia and Severe InflammationMedicine Published on 2021-06-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission AST Blood Blood coagulation C-reactive protein calcitonin Chest CT image China CK-MB Clinical characteristics coagulation dysfunction coagulation function compared and analyzed Concentration correlated COVID 19 COVID-19 COVID-19 infected patient COVID-19 patient CRP D-dimer Decreased Degradation detect Diagnosis Electrolytes enrolled erythrocyte sedimentation rate ESR exhibited Fever function functions Ground glass opacity Hypocalcemia IL-6 increase in infected patients Infection Inflammation Inflammatory factor inflammatory factors information Jin Kidney function Laboratory test LDH liver lung metabolic disorder metabolic dysfunction Mild mild cases mild infection MOST myocardial enzymes New coronavirus Older patchy Patient PCT Pneumonia positively correlated procalcitonin routine blood tests serum calcium Severe case severe cases Severe COVID-19 Infection severe COVID-19 infections Severe infection significant decrease significant increase significantly systemic inflammation Treatment Trial Wuhan Wuhan, China X-ray [DOI] 10.3389/fmed.2021.638194 PMC 바로가기 [Article Type] Medicine
High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumoniaArticle Published on 2021-05-242022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, [키워드] acute phase response Analysis association body mass index C-reactive protein Comorbidity Concentration concentrations correlated COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients Cytokines dysregulated immune response enrolled Fatty acid feature form HDL High-density lipoprotein cholesterol hospitalized patient Immunopathogenesis Infection initial intensive care lipoprotein metabolism metabolic disorder MOST NEFA Non-COVID-19 obese patients Organ failure outcome Pathogenesis patients hospitalized plasma plasma concentration Pneumonia Polyunsaturated PUFA required respiratory severity Sepsis Severe COVID-19 pneumonia severe pneumonia SOFA therapeutic targets to define unique Ventilator-free days were assessed with COVID-19 [DOI] 10.1038/s41598-021-90362-9 PMC 바로가기 [Article Type] Article