Microbiome and intestinal pathophysiology in post-acute sequelae of COVID-19Review Article Published on 2023-06-192024-09-05 Journal: Genes & Diseases [Category] update2024, [키워드] gastrointestinal symptoms GI Tract gut microbiome inflammatory bowel diseases Intestinal barrier Long COVID metabolites tight junctions [DOI] 10.1016/j.gendis.2023.03.034 PMC 바로가기 [Article Type] Review Article
Persistent biofluid small molecule alterations induced by Trypanosoma cruzi infection are not restored by antiparasitic treatmentArticle Published on 2023-06-032024-09-05 Journal: bioRxiv [Category] update2024, [키워드] Biomarkers Chagas disease Clinical treatment failure metabolites Trypanosoma cruzi Urine [DOI] 10.1101/2023.06.03.543565 PMC 바로가기 [Article Type] Article
Fetal effects of mild maternal COVID-19 infection: metabolomic profiling of cord bloodOriginal Article Published on 2023-04-152024-09-05 Journal: Metabolomics [Category] update2024, [키워드] Cord blood COVID-19 fetus mass spectrometry metabolites metabolomics Nuclear magnetic resonance spectroscopy Pregnancy [DOI] 10.1007/s11306-023-01988-x PMC 바로가기 [Article Type] Original Article
Gut microbiota and its metabolites in depression: from pathogenesis to treatmentReview Published on 2023-03-222024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] Depression gut microbiota metabolites Microbial-targeted therapeutics Pathogenesis [DOI] 10.1016/j.ebiom.2023.104527 PMC 바로가기 [Article Type] Review
Identifying the Novel Gut Microbial Metabolite Contributing to Metabolic Syndrome in Children Based on Integrative Analyses of Microbiome-Metabolome Signaturesarticle Published on 2023-02-162024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] children Inflammation lipid metabolism metabolic syndrome metabolites microbiota [DOI] 10.1128/spectrum.03771-22 PMC 바로가기 [Article Type] article
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell deathArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] acid Alter alteration Biomarker caused cell death change circulating Cohort contribute COVID-19 COVID-19 patient disease dysfunction Europe exclusion FABP2 functional Gut immune include increase in Infection Inflammation Inflammatory responses inhibited marker median metabolites microbial product Mild moderate NMR outliers pathology Patient patients with moderate plasma Plasma marker positive correlation reduced reduction in route of infection SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease severe group Severity of disease shown systemic [DOI] 10.1038/s41598-022-23282-x PMC 바로가기
Griseofulvin: An Updated Overview of Old and Current KnowledgeArticle Published on 2022-10-182022-11-16 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, [키워드] ACE2 addition ascomycetes binding cancer cell capillary blood flow Cell contribute current derivative dermatophytic fungi disrupt domain Drug repurposing ENhance explain FDA-approved drug filament protein griseofulvin griseofulvin derivatives gsf gene cluster Hepatitis hepatitis C virus hepatocyte IMPROVE infections information inhibitory effect Inhibitory effects Interaction introduced K18 Liver injury Mallory mechanism metabolite metabolites mitosis molecular docking analysis multifunctional polyketide compound produced RBD RdRP Replication responsible RNA-dependent RNA polymerase rodent SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 main protease severity Spike protein spindle microtubule. therapeutic interventions treated Vascular viral replication [DOI] 10.3390/molecules27207034 PMC 바로가기
Comparative Assessment of the Inhibitory Potential of the Herbicide Glyphosate and Its Structural Analogs on RGD-Specific Integrins Using Enzyme-Linked Immunosorbent AssaysArticle Published on 2022-10-172022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation AMPA assessment binding biochemical Cell Comparative demonstrated derivative ECM ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Extracellular matrix fibrinogen glycoprotein glyphosate Herbicide ingredient inhibition inhibitory effect integrin Integrins integrins αVβ3 metabolite metabolites pathway physiological functions Polymer Potential Protein Receptor binding domain SARS-CoV-2 receptor SARS-COV-2 receptor binding domain Spike protein structural analogs the SARS-CoV-2 Total α5β1 αllbβ3. [DOI] 10.3390/ijms232012425 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
Reactivity and binding mode of disulfiram, its metabolites, and derivatives in SARS-CoV-2 PLpro: insights from computational chemistry studiesArticle Published on 2022-10-122022-11-15 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral action antiviral activity Antiviral compounds applied binding clinical trial COVID-19 cysteine residue derivative DFT calculations disulfiram docking DSF in vitro in vivo inhibiting inhibitor mechanism metabolite metabolites Organochalcogens. Papain-like protease Safe SARS-CoV-2 tested [DOI] 10.1007/s00894-022-05341-2 PMC 바로가기