metabolomic – Page 2 – Communicable Diseases Research

Sex differences in global metabolomic profiles of COVID-19 patients

COVID-19 환자의 글로벌 대사 프로필의 성별 차이

Article

Published on 2022-05-142022-09-11
Journal: Cell Death & Disease
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료제,

Sera Metabolomics Characterization of Patients at Different Stages in Wuhan Identifies Critical Biomarkers of COVID-19

우한의 여러 단계에 있는 환자의 혈청 대사체학 특성 분석으로 COVID-19의 중요한 바이오마커 식별

Article

Published on 2022-05-022022-09-11
Journal: Frontiers in Cellular and Infection Microbiology
[Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alpha-methylstyrene Biomarker Biomarkers caused characterization chavicol clinical disease clinical measurement clinical measurements comprehensive analysis coronavirus Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical death degranulation differentially expressed example feature identification immune responses information Intervention involved knowledge lead metabolism metabolite metabolites metabolomic metabolomic analysis metabolomics Pathogenesis pathway Patient patients performed phosphate physiological Platelet potential therapeutic agent potential therapeutic agents predicted propylparaben rehabilitation patient respiratory SARS-CoV-2 sera serum severe acute respiratory syndrome Coronavirus Spread Stage stages stages. therapeutic agents therapeutic target therapeutic targets triethanolamine uninfected Wuhan
[DOI] 10.3389/fcimb.2022.882661 PMC 바로가기 [Article Type] Article

Laboratory Biomarkers for Diagnosis and Prognosis in COVID-19

COVID-19 진단 및 예후를 위한 실험실 바이오마커

Review

Published on 2022-04-272022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘,

[키워드] Admission Analysis aspartate Aspartate transaminase AST Biomarker Biomarkers BNP Brain brain natriuretic peptide cause clinical manifestations Clinical practice coronavirus disease Coronavirus disease 2019 COVID-19 creatine creatine kinase Cytokines D-dimer Diagnosis diagnostic disease severity focus Future Hospitalization ICU identify include Inflammation intensive care intensive care unit laboratory biomarker laboratory biomarkers Lactate lactate dehydrogenase LDH Lymphocytes metabolomic metabolomics Mortality multiorgan failure Myoglobin N-terminal Neuron-specific enolase neutrophil neutrophil count Neutrophils NT-proBNP outcome outcomes peptide predict Prognosis Prognostic value progression proinflammatory cytokines proteomic proteomics proteomics. Research respiratory risk stratification SARS-CoV-2 Severe acute respiratory syndrome severe cases severe COVID-19 shown translated
[DOI] 10.3389/fimmu.2022.857573 PMC 바로가기 [Article Type] Review

Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19

스트레스가 많은 사건은 COVID-19와 싸우는 의료 종사자의 장기적인 장내 미생물 불균형 및 외상 후 스트레스 증상을 유발합니다

Article

Published on 2022-04-152022-09-11
Journal: Journal of affective disorders
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] 16S rRNA 16S rRNA gene Anti-inflammatory effects Anxiety association Bacteria Bacteroide Brain change changes characteristic COVID-19 Day Depression determinant disorders Eubacterium event Evidence experiment Faecalibacterium Follow-up frontline healthcare workers Frontline medical worker full-length Full-length 16S rRNA sequencing Gut gut microbiome gut microbiota healthcare worker indicated induce investigated lack longitudinal change longitudinal changes mechanism Mental mental health metabolomic microbe microbes microbial Microbial dysbiosis pathway post-traumatic stress symptom Post-traumatic stress symptoms problem Psychological Psychological stress rRNA sequence Sequencing Stress stress symptoms stress. Stressor trajectory
[DOI] 10.1016/j.jad.2022.02.024 PMC 바로가기 [Article Type] Article

Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients

통합된 조직병리학, 지질학 및 대사체 프로필은 밍크가 심각한 COVID-19 환자의 병원성을 모방하는 유용한 동물 모델임을 보여줍니다

Article

Published on 2022-01-282022-09-10
Journal: Signal Transduction and Targeted Therapy
[Category] Fulltext, SARS, 바이오마커, 진단, 치료법, 치료제,

[키워드] Absorption accompanied activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus alteration alveolar damage amino acids analysis animal model Anti-inflammatory characterized cholesterol contributed coronavirus correlated COVID-19 patients demonstrated Diffuse alveolar damage digestion digestive distribution downregulated dysregulation effective Effects Endocrine fatal COVID-19 feature fetal hepatic dysfunction highlight histological histopathological Human immune dysregulation immune systems immunomodulating Infection Infectious diseases Inflammatory response inoculation Kynurenine Kynurenine pathway lesion Lipid lipids Macrophage macrophage activation macrophages melatonin metabolic pathways metabolite metabolites metabolomic observation pathogenicity pathophysiological feature Patient post inoculation potential biomarkers profile Proteins reported Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient significantly Steroids transmitted Treatment strategies Vaccine Viral Viral protein vitamins was related widespread
[DOI] 10.1038/s41392-022-00891-6 PMC 바로가기 [Article Type] Article

Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment

Covid-19 심각도 및 치료의 정확한 모니터링을위한 대사 및 면역 마커

Immunology

Published on 2022-01-122022-08-31
Journal: Frontiers in Immunology
[Category] MERS, 바이오마커, 진단,

Systematic review with meta-analysis of diagnostic test accuracy for COVID-19 by mass spectrometry

질량분석기를 통한 코로나19 진단검사 정확도 메타분석을 통한 체계적인 검토

Meta-Analysis

Published on 2022-01-012022-09-12
Journal: Metabolism: clinical and experimental
[Category] MERS, 진단,

[키워드] Accuracy addition Admission analysis applicability AUROC, Area Under Receiver Operating Characteristic averaged breath characteristic Cohort studies complement controls COVID-19 COVID-19 diagnosis COVID-19 infection COVID-19 pandemic DI, Direct Injection diagnosis of COVID-19 diagnostic Diagnostic accuracy diagnostic test diagnostic tests diagnostics ESI, Electrospray Ionization FAIMS, high-Field Asymmetric-waveform Ion-Mobility Spectrometry feature finding Future future work GC, Gas Chromatography HESI, Heated Electrospray Ionization heterogeneity highlight IMS, Ion Mobility Spectrometry index Infection interquartile range Laboratory LC, Liquid Chromatography less MALDI, Matrix Assisted Laser Desorption Ionization mass spectrometry Meta-analysis metabolomic Nasopharyngeal swab nasopharyngeal swabs nLC, nano-Liquid Chromatography NMR, Nuclear Magnetic Resonance Observational cohort study participant performed plasma positive proteomic protocol protocols QTOF, Quadrupole Time of Flight QUADAS-2 questionnaire receiver operating characteristic retrospective risks of bia ROC, Receiver Operating Characteristic RT-PCR RT-PCR, Polymerase Chain Reaction combined with Reverse Transcription Saliva sensitivity serum specificity systematic review TFC, Turbulent Flow Chromatography TOF, Time of Flight translated UHPLC, Ultra High pressure Liquid Chromatography were assessed
[DOI] 10.1016/j.metabol.2021.154922 PMC 바로가기 [Article Type] Meta-Analysis

Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections

Article

Published on 2021-12-112022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

[키워드] acute respiratory syndrome Affect analysis Antiviral antiviral drug combination antiviral property Calu-3 cell changes in clinical development Combination concentrations convalescent serum coronavirus cycloheximide demonstrated drug effective EIDD-2801 HCV hepatitis C virus hepatitis E virus HIV homeostasis Human immunodeficiency virus IFN IFNs IFNα in vitro indicated influenza A virus interferon interferon-alpha lung organoids metabolomic NITD008 organoids Other protein synthesis Remdesivir Replication ribavirin SARS-CoV-2 Side effects suppressed synergistic target tested therapeutic potential tolerable Transcription uninfected cell viral infections Viral RNA while
[DOI] 10.3390/v13122489 PMC 바로가기 [Article Type] Article

Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis

중증 COVID-19 환자의 입원 시 아미노산 대사가 크게 변경됨: 종단 표적 대사체학 분석 결과

Observation

Published on 2021-12-082022-09-10
Journal: Microbiology Spectrum
[Category] SARS, 바이오마커,

[키워드] acid acute phase addition Altered approach arginine biomarker signature Care citrulline clinical manifestation clinical manifestations Clinical severity complement complementary Course COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients Defense defense mechanisms Deprivation described disease Disease progression disease stage effective evaluate Evidence evidence of finding fluctuation fluctuations followed by functional Glutamine heterogeneity highlight hospitalized patient Host host defense immune response immune responses Infection inhibited knowledge Kynurenine list longitudinal longitudinal study M2 macrophage polarization Macrophage marker mechanism metabolic pathway metabolic pathways metabolism metabolite metabolites metabolomic metabolomic profiling metabolomic signature metabolomics molecular molecular mechanism molecular mechanisms ornithine outcome Pathogenesis pathogenesis of COVID-19 pathway Pathways Patient Phenylalanine profile SARS-CoV-2 SARS-COV-2 infection serum serum sample serum samples severity the disease time Tryptophan tyrosine Virus-host interactions
[DOI] 10.1128/spectrum.00338-21 PMC 바로가기 [Article Type] Observation

Longitudinal Metabolomics Reveals Ornithine Cycle Dysregulation Correlates With Inflammation and Coagulation in COVID-19 Severe Patients

Microbiology

Published on 2021-12-032022-10-31
Journal: Frontiers in Microbiology
[Category] COVID-19,

[키워드] amino acid metabolism amino acids analyzed association biochemical Biochemical parameters Blood change Coagulation correlated COVID-19 COVID-19 patient COVID-19 patients creating cycle cytokine Cytokines diagnostic dipeptides discharge Disease progression drug dysregulation FIVE global pandemic humans Inflammation longitudinal longitudinal change marker metabolic disorder metabolic factor metabolite metabolites metabolome metabolomic metabolomics Mild nine ornithine ornithine cycle pathogenic mechanisms pathogenicity peptides potential mechanism provided SARS-CoV-2 SARS-COV-2 infection serum severe disease Severe patient severe patients significantly significantly higher valuable resource
[DOI] 10.3389/fmicb.2021.723818 PMC 바로가기 [Article Type] Microbiology