Addressing personal protective equipment (PPE) decontamination: Methylene blue and light inactivates severe acute respiratory coronavirus virus 2 (SARS-CoV-2) on N95 respirators and medical masks with maintenance of integrity and fit개인 보호 장비(PPE) 오염 제거 처리: 메틸렌 블루 및 라이트는 무결성과 적합성을 유지하면서 N95 호흡기 및 의료용 마스크에서 중증 급성 호흡기 코로나바이러스 2(SARS-CoV-2)를 비활성화합니다.Article Published on 2022-07-012022-09-12 Journal: Infection Control and Hospital Epidemiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Arm coronavirus coronavirus disease Coronaviruses COVID-19 determine effective equipment hydrogen peroxide inactivated inoculated International Mask Medical mask Methylene blue N95 respirator pandemic Personal protective equipment photochemical PPE Respirator Respiratory Coronavirus SARS-CoV-2 tested treated Treatment virus virus inactivation was used [DOI] 10.1017/ice.2021.230 PMC 바로가기 [Article Type] Article
Immunoassay platform with surface-enhanced resonance Raman scattering for detecting trace levels of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 미량 수준을 검출하기 위한 표면 강화 공명 라만 산란 기능이 있는 면역 분석 플랫폼Article Published on 2022-07-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation antibody coated with comparable Concentration conjugation Conjugation in gold nanoparticles coronavirus disease COVID-19 COVID-19 patient COVID-19 patients disease early diagnosis genetic material gold Gold nanoparticle immunoassay lack limit of detection lowest Methylene Methylene blue multidimensional onset of symptoms plasma platform prevented Protein Resonant Raman molecules SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike protein detection scattering SERRS immunoassay Platform silica Silica shell functionalization. Spike protein Support the immunoassay Viral proteins [DOI] 10.1016/j.talanta.2022.123381 PMC 바로가기 [Article Type] Article
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulationArticle Published on 2022-06-012022-10-04 Journal: Photochemical & photobiological sciences : Official journal of the European [Category] COVID19(2023년), SARS, 신약개발, [키워드] amplification amplitude antimicrobial Antimicrobial photodynamic disinfection approved clinical sample Clinical use collected Concentration condition coronavirus disease COVID-19 COVID-19 patients cytotoxicity early stage exhibiting form global effort HEK293T cells infect Infection lentiviral luciferase reporter gene medical need Medicines Methylene Methylene blue nasal pandemic PDI photodisinfection photodynamic inactivation prevented pseudotyped Pseudotyped lentiviral vector reduce SARS-CoV-2 severity the disease the S protein Transmission Treatment urgency Viral load [DOI] 10.1007/s43630-022-00202-6 PMC 바로가기 [Article Type] Article
Longer amplicons provide better sensitivity for electrochemical sensing of viral nucleic acid in water samples using PCB electrodes더 긴 앰플리콘은 PCB 전극을 사용하여 물 샘플에서 바이러스 핵산의 전기화학적 감지에 더 나은 감도를 제공합니다.Article Published on 2022-05-252022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] Amplicon amplicons COVID-19 pandemic demonstrated detect determine DNA DNA fragment effort Formula gel gold gold standard Interaction Methylene Methylene blue Modification offer PCR PCR product PCR products prominence purification salt SARS-CoV-2 sensitivity significantly Surveillance text Viral load viral nucleic acid water [DOI] 10.1038/s41598-022-12818-w PMC 바로가기 [Article Type] Article
Evaluation of methylene blue based photodynamic inactivation (PDI) against intracellular B-CoV and SARS-CoV2 viruses under different light sources in vitro as a basis for new local treatment strategies in the early phase of a Covid19 infectionCovid19 감염 초기 단계의 새로운 국소 치료 전략의 기초로서 시험관 내 다양한 광원에서 세포 내 B-CoV 및 SARS-CoV2 바이러스에 대한 메틸렌 블루 기반 광역학 불활화(PDI) 평가Article Published on 2022-03-012022-09-11 Journal: Photodiagnosis and photodynamic therapy [Category] SARS, 치료기술, [키워드] Antiviral aPDT (antimicrobial photodynamic therapy). approach Cell Concentration Corona viruses dark dose early phase experiment Extracellular in vitro inactivation Incubation infected cell infected cells Infection intensity Laser Local logarithmic reduction low dose Methylene Methylene blue nose and throat PDI PDI (photodynamic inactivation) phenothiazine Phenothiazine dye in aPDT photodynamic inactivation photodynamic therapy photosensitizer Prognosis radiation intensity reducing reduction SARS-CoV-2 SARS-CoV-2 inactivation SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV2 sensitizer substitute therapy treated treatment strategy Vero E6 Viral load virus was reduced [DOI] 10.1016/j.pdpdt.2021.102642 PMC 바로가기 [Article Type] Article
Cytokine Storm in COVID-19: Immunopathogenesis and TherapyCOVID-19의 사이토카인 폭풍: 면역 병인 및 치료Review Published on 2022-01-182022-09-12 Journal: Medicina [Category] SARS, 진단, [키워드] administration affected Allogeneic allogeneic hematopoietic stem cell transplantation Anakinra antibody autoinflammatory disease CAR Care clinically Coagulopathy conditions coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill critically ill patients cytokine cytokine inhibitors Cytokine storm Cytokines death deregulated disease disease severity effective effort excessive production of cytokines glucocorticoid Glucocorticoids GM-CSF Graft Graft-versus-host disease Hematopoietic stem cell hemophagocytic lymphohistiocytosis Hope hyperinflammatory state IFN-γ IL-1 IL-10 IL-2 IL-6 immune cells immune system IP-10 jak inhibitors leading MCP-1 Methylene blue mitigate multi-organ failure Novel coronavirus novel coronavirus disease overcome pandemic Pathogenesis Patient Plasmapheresis pro-inflammatory cytokines reducing mortality secondary hemophagocytic lymphohistiocytosis secondary to Sepsis severe cases stem cell Stem cell transplantation storm syndrome T-cell tested the cytokine storm the disease therapeutic strategy therapy TNF-α to define Tocilizumab [DOI] 10.3390/medicina58020144 PMC 바로가기 [Article Type] Review
Ultrasonic scaling in COVID-era dentistry: A quantitative assessment of aerosol spread during simulated and clinical ultrasonic scaling procedures코로나 시대 치과의 초음파 스케일링: 시뮬레이션 및 임상 초음파 스케일링 절차 중 에어로졸 확산의 정량적 평가Article Published on 2021-11-012022-09-11 Journal: International journal of dental hygiene [Category] SARS, 치료기술, [키워드] aerosol aerosol spread aerosol-generating procedure aerosol-generating procedures Aerosols agency calculate Concentration COVID-19 dental hygiene dental hygiene research diameter disease droplet droplets hand highest hygiene in vivo infectious agents Instrumentation instrumentation: hand Methylene Methylene blue mitigate mouth Particle Particles Patient Personal protective equipment professional practice profile quantitative assessment Region Saliva sonic Spread stain Test the patient Transmission Travel Ultrasonic was performed water while zone [DOI] 10.1111/idh.12548 PMC 바로가기 [Article Type] Article
Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigationsCOVID-19의 관리에서 메틸렌 블루 리포지션 : 기계적 측면 및 임상 조사Review Published on 2021-10-012022-08-31 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS, 신약개발, 임상, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome affecting anti-cytokine Antiviral applicability approved can not caused clinical investigation Clinical studies clinical study Coronaviruses COVID-19 critical cases cytokine Cytokine storm Cytokines dose drug drugs Efficacy examined explained failure free radical Free radicals Health Organization human host humans Infection inhibit Leucomethylene blue lung Lungs management Methylene Methylene blue multi-organ failure nitric oxide Nitric oxide pathway other diseases pandemic reported repurposing researcher respiratory respiratory distress Respiratory distress syndrome Respiratory system respiratory tract Safe SARS-CoV-2 Severe acute respiratory syndrome Shock syndrome the disease therapeutic therapeutic agent Treatment US FDA World Health Organization [DOI] 10.1016/j.biopha.2021.112023 PMC 바로가기 [Article Type] Review
What Binds Cationic Photosensitizers Better: Brownian Dynamics Reveals Key Interaction Sites on Spike Proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2Article Published on 2021-08-152022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] bind binding domain binding site Brownian dynamics cationic complexes conformation connection Contact Coronaviruses domain Dynamics electrostatic fusion protein heptad repeat Interaction MERS-CoV Methylene blue N-terminal domain notable octakis(cholinyl)zinc phthalocyanine penetrate photosensitizer S-protein SARS-CoV SARS-CoV-2 SARS-CoV-2 receptor Site spike Spike protein Spread the spike protein [DOI] 10.3390/v13081615 PMC 바로가기 [Article Type] Article
The oxygen dissociation curve of blood in COVID-19코로나19 혈액의 산소 해리 곡선Review Published on 2021-08-012022-09-11 Journal: American journal of physiology. Lung cellular and [Category] SARS, 치료기술, [키워드] affinity Anemia ATP Blood blood sampling calculated caused Cell change Concentration contrary COVID-19 dissociation curve distribution equilibration erythropoietin Factors functional Glutamate glutathione half-saturation pressure hemoglobin hemoglobin oxygen affinity Hemolysis in vivo in vivo oxygen dissociation curve increase interstitial fluid Lactate lung Lungs methemoglobin Methylene Methylene blue oxygen oxygen affinity oxygen dissociation reduce reduced reduction saturation saturation pressure therapy tissue tissues Transport Volume [DOI] 10.1152/ajplung.00079.2021 PMC 바로가기 [Article Type] Review