Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening공유 도킹 기반 가상 스크리닝을 통한 SARS-CoV-2 주요 프로테아제 억제제의 선도적 발견Article Published on 2021-04-262022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료제, [키워드] acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approval candidate characterized chymotrypsin Clinical data coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cure cysteine cysteine protease database docking drug Economy effective drug effective drugs effort EMA enzyme European Medicines Agency FDA food Health house identify in silico inhibitor Ligand M pro Michael pandemic peptide predict predictive power risk SARS-CoV-2 Screening severe acute respiratory syndrome Coronavirus target protein the SARS-CoV-2 treat Vaccine Virtual screening [DOI] 10.1021/acs.jcim.1c00184 PMC 바로가기 [Article Type] Article
How will COVID-19 transform global health post-pandemic? Defining research and investment opportunities and prioritiesEditorial Published on 2021-03-112022-10-29 Journal: PLoS Medicine [Category] Coronavirus, SARS, [키워드] Collection COVID-19 Health Michael Research [DOI] 10.1371/journal.pmed.1003564 PMC 바로가기 [Article Type] Editorial
A Duty to treat? A Right to refrain? Bangladeshi physicians in moral dilemma during COVID-19Research Published on 2020-09-092022-10-29 Journal: Philosophy, Ethics, and Humanities in Medicine : P [Category] COVID-19, SARS, [키워드] absence Admission Analysis automatically autonomous Bangladesh Care clinical care condition contrary country COVID-19 COVID-19 pandemic COVID-19 patients dereliction duty Duty to treat examined expected Government Guidance hospital Immanuel initial medical ethics Michael National pandemic Patient patients Perry Personal protective equipment physician PPE Practitioner presenting Professional autonomy recommendations respond Result right Symptoms Tolerance transfer Transport treat USA with COVID-19 [DOI] 10.1186/s13010-020-00091-6 PMC 바로가기 [Article Type] Research
Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug DesignArticle Published on 2016-03-072022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Analysis anti-CoV drug antiviral therapeutics antiviral therapy biochemical caused children complex coronavirus CoV genome CoVs Critical drug effective enzyme HCoV-NL63 Human coronavirus human CoV human CoVs Infection infections inhibitor insight isolate Lower respiratory tract M pro MERS-CoV Michael molecular mechanism molecular target Netherland NL63 Pneumonia presenting protease Proteolytic processing provide reveal RNA SARS-CoV sequence Spectrum Strains Structure Symptom treat viral replication zoonotic CoVs [DOI] 10.1038/srep22677 PMC 바로가기 [Article Type] Article