Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and OutcomeCOVID-19 사망률 환자의 상부 기도에서 증가된 Achromobacter xylosoxidans 및 Bacillus cereus는 질병 심각도 및 결과에서 공동 감염의 역할을 나타냅니다.Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] abundance Achromobacter Actinomyce Alter Analysis Antibiotic therapy approaches Bacillus cereus Bacterial bacterial species bacterial specy Care clinical manifestation Co-infection complementary complications of COVID-19 contribute COVID-19 COVID-19 patient current disease disease outcome disease pathology disease severity disease sub-phenotype Exacerbation Factor feature functional groups highlight Holo-Seq hospital host-pathogen interactions Increased Inflammatory response Inflammatory responses Integrative analysis investigated involved isolate isolates Leptotrichia mechanism Medical care metabolic pathways microbe microbial Mild mild COVID-19 patients moderate modulate modulating Mortality nasopharyngeal nasopharyngeal RNA outcome parameters pathogen pathogen genomics Patient patients phenotype Phenotypes Phylogenetic analysis progression provide question recovered patient recovered patients reported respiratory virus respiratory virus oligo panel (RVOP) role SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 pathogenesis Sequencing severe COVID-19 severe disease severity susceptibility Symptoms the disease the patient transcript transcriptionally transcriptionally active microbial isolates. Transmissibility upper vaccination variants variants of concern VoC window [DOI] 10.1128/spectrum.02311-21 PMC 바로가기 [Article Type] Article
Stressful events induce long-term gut microbiota dysbiosis and associated post-traumatic stress symptoms in healthcare workers fighting against COVID-19스트레스가 많은 사건은 COVID-19와 싸우는 의료 종사자의 장기적인 장내 미생물 불균형 및 외상 후 스트레스 증상을 유발합니다Article Published on 2022-04-152022-09-11 Journal: Journal of affective disorders [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 16S rRNA 16S rRNA gene Anti-inflammatory effects Anxiety association Bacteria Bacteroide Brain change changes characteristic COVID-19 Day Depression determinant disorders Eubacterium event Evidence experiment Faecalibacterium Follow-up frontline healthcare workers Frontline medical worker full-length Full-length 16S rRNA sequencing Gut gut microbiome gut microbiota healthcare worker indicated induce investigated lack longitudinal change longitudinal changes mechanism Mental mental health metabolomic microbe microbes microbial Microbial dysbiosis pathway post-traumatic stress symptom Post-traumatic stress symptoms problem Psychological Psychological stress rRNA sequence Sequencing Stress stress symptoms Stressor trajectory [DOI] 10.1016/j.jad.2022.02.024 PMC 바로가기 [Article Type] Article
PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19PathogenTrack 및 Yeskit: COVID-19에 적용하여 설명된 단일 세포 RNA 시퀀싱 데이터 세트에서 세포내 병원체를 식별하기 위한 도구Article Published on 2022-04-012022-09-11 Journal: Frontiers of medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] addition Analysis Antigen Bacteria bacterium BALF Bronchoalveolar lavage fluid cancers cell type cellular cellular distribution Co-infection COVID-19 COVID-19 patient COVID-19 patients database dataset dysfunction epithelial cell epithelial cells feature fungi Github Haemophilus host cell host cells identify immune response in some increased expression induce Infectious disease interferon pathway intracellular pathogen introduced Macrophage macrophages microbe neutrophil other disease other diseases pathogen Pathogens pathway presenting R package raw data robustness SARS-CoV-2 SARS-CoV-2 virus scRNA-seq scRNA-seq data scRNA-seq datasets Severe case single-cell level Single-cell RNA-sequencing SRA Still Taking tested the SARS-CoV-2 virus transcriptomic type I interferon type I interferon pathway viruses [DOI] 10.1007/s11684-021-0915-9 PMC 바로가기 [Article Type] Article
Metagenomic Sequencing and Reverse Transcriptase PCR Reveal That Mobile Phones and Environmental Surfaces Are Reservoirs of Multidrug-Resistant Superbugs and SARS-CoV-2Metagenomic Sequencing 및 Reverse Transcriptase PCR, 휴대전화와 환경 표면이 다제내성 슈퍼버그 및 SARS-CoV-2의 저장소임을 밝혀내다Article Published on 2022-03-082022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료기술, [키워드] Acinetobacter aggregation Analysis antimicrobial resistance Aspergillus Bacterial bacteriophages Care carried Combination Community conducted Contamination COVID-19 COVID-19 patients Culture dissemination drug-resistant Emergency fomites fungi HCW HCWs healthcare worker Healthcare workers hospital Malassezia metagenomic metagenomic sequencing methicillin methicillin-resistant Staphylococcus aureus microbe microbes microbial Mobile mobile phone mobile phones molecular motility non-COVID-19 patient Non-COVID-19 patients P. aeruginosa pathogen pathogenic Patient PCR phenotypic point prevalence positive predominant preponderance Prevalence Pseudomonas Pseudomonas aeruginosa reservoir resistance gene risk RT-PCR SARS-CoV-2 SARS-CoV-2 detection Sequencing shotgun shotgun metagenomics. Staphylococcus Staphylococcus aureus Staphylococcus epidermidis surface Swab swabs transfer virulent zone [DOI] 10.3389/fcimb.2022.806077 PMC 바로가기 [Article Type] Article
Dysbiosis of Oral and Gut Microbiomes in SARS-CoV-2 Infected Patients in Bangladesh: Elucidating the Role of Opportunistic Gut MicrobesMedicine Published on 2022-02-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Analysis Bacteria Bacterial Bacteroide Bangladesh breathing difficulty caused clinical condition clinical outcomes clinical sample collected consortia contribute controls COVID-19 diabetes diagnostics diarrhea Dysbiosis Escherichia Gut healthy healthy control healthy controls hospitalized patient implication Infectious disease Interaction mapped metabolic pathways metagenomic sequencing metagenomics microbe microbial microbial community Microbiome oral oral and gut microbiome oral microbiota paired-end read pandemic disease patients with COVID-19 Prevotella reduced reduction in role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severity Shigella significantly significantly lower sore throat Streptococcus susceptibility the patient unique with COVID-19 [DOI] 10.3389/fmed.2022.821777 PMC 바로가기 [Article Type] Medicine
Leishmaniac Quest for Developing a Novel Vaccine Platform. Is a Roadmap for Its Advances Provided by the Mad Dash to Produce Vaccines for COVID-19?Review Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activate adjuvanticity advance antigen-presenting cell APC application approach Cancer vaccine Candidates cationic CD8+ T cells cell inactivation Complete COVID-19 cytosolic DASH Developing disciplinary Diseases effective effectively deliver Efficacy elicit elicited ENhance epitope etiological agent greater highlight Immunity in vitro inactivated inactivation Leishmania Leishmaniasis life-long immunity mechanism MHC molecule microbe Mouse models novel OVA ovalbumin pandemic Patient predicted previous study processed Produce PROTECT provide quest reactive resulting SARS-CoV-2 short-lived shown singlet oxygen spike protein-based vaccine Support suppress susceptible the disease the vaccine these cell Trigger urgency vaccination Vaccine Vaccines whole-cell vaccine platform [DOI] 10.3390/vaccines10020248 PMC 바로가기 [Article Type] Review
SARS‐CoV‐2 triggered oxidative stress and abnormal energy metabolism in gut microbiotaOriginal Article Published on 2022-01-172022-10-30 Journal: MedComm [Category] COVID-19, [키워드] ABC accompanied Actinomyce alteration Amino acid analyzed annotation Antiviral Bacteria Bacteroide Biomarkers Butyrate characteristic characterized collected controls correlated COVID‐19 COVID‐19 patient COVID‐19 Critical Defense disease severity energy metabolism ENhance Escherichia coli exacerbate expression Fecal sample functions genes encoding Gut gut microbiota indicated Infection inflammation response Inflammatory intestinal flora KEGG Kyoto mechanism metabolism metagenome metagenomic metatranscriptome metatranscriptomic microbe Microbiome Neutral Ontology oxidative stress pathogen pathway positively correlated progression reduced SARS‐CoV‐2 SARS‐CoV‐2 virus SARS‐CoV‐2 selected Sequencing severity significantly Specific sphingolipids Streptococcus sugar suggested triggered upregulated upregulation was performed [DOI] 10.1002/mco2.112 PMC 바로가기 [Article Type] Original Article
Respiratory tract infections and gut microbiome modifications: A systematic reviewResearch Article Published on 2022-01-132022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] 95% CI absence alteration Analysis article bacterial pathogen caused change changes in clinical Cohort cohort study conducted Control coronavirus 2 decrease Effect Effects eligible Enterococcus evaluate Evidence explained for inclusion gastrointestinal tract Gut gut microbiota H1N1 H7N9 Health healthy control heterogeneity Infection infections Influenza lack microbe Microbiome Patient reported respiratory SARS-CoV-2 searched Symptom systematic review Variation was performed Web of Science [DOI] 10.1371/journal.pone.0262057 PMC 바로가기 [Article Type] Research Article
COVID19db: a comprehensive database platform to discover potential drugs and targets of COVID-19 at whole transcriptomic scaleCOVID19db: 전체 전사체 규모에서 COVID-19의 잠재적 약물 및 표적을 발견하기 위한 포괄적인 데이터베이스 플랫폼AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] 유전자 메커니즘, 치료제, [키워드] accelerate Analysis clinical information coronavirus disease Coronavirus disease 2019 COVID-19 database dataset datasets drug Effective strategies effective strategy facilitate grouping heterogeneity identify include Interaction mandatory mechanism microbe Open Access platform proof proof of concept provide researcher target targets Transcriptome transcriptomes transcriptomic transcriptomic data [DOI] 10.1093/nar/gkab850 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Multipurpose Drugs Active Against Both Plasmodium spp. and Microorganisms: Potential Application for New Drug DevelopmentPlasmodium spp.및 미생물 : 신약 개발을위한 잠재적 적용Review Published on 2021-12-242022-08-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 신약개발, 치료제, [키워드] active against Against Antimalarial drugs antimicrobial application Artemisinin Bacteria caused chemotherapeutic agent combination therapy COVID-19 develop development disease Diseases drug drugs Ebola virus disease effective Endemic example focus fungi help Infectious diseases Influenza influenza pandemic information kill knowledge malaria malaria parasites mechanism mechanism of action microbe microorganism microorganisms New not achieved parasite patients Plasmodium Potential problem protozoan parasite Region repurposing the WHO Treatment Virus Disease viruses [DOI] 10.3389/fcimb.2021.797509 PMC 바로가기 [Article Type] Review