Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse modelsResearch article Published on 2020-11-012022-10-05 Journal: Antiviral Research [Category] 비임상, [키워드] Abnormalities addition Anti-viral association Brain Brazil castanospermine combating CST disorders immunosuppressive property Infection Inflammation inhibiting microcephaly mouse model neurological neurological abnormalities neuronal Occurrence outbreak Outbreaks paralysis reduce reduced reported resulting Seizure Spread tissues Viral load Zika virus ZIKV [DOI] 10.1016/j.antiviral.2020.104935 [Article Type] Research article
Zika Virus: Relevance to the State of Hawai’iArticle Published on 2019-04-012023-06-22 Journal: Hawaii J Med Public Health [Category] 조류인플루엔자, [키워드] congenital Zika syndrome Hawai‘i microcephaly Zika virus PMC 바로가기
A Possible Mechanism of Zika Virus Associated Microcephaly: Imperative Role of Retinoic Acid Response Element (RARE) Consensus Sequence Repeats in the Viral GenomeArticle Published on 2016-08-092023-08-30 Journal: PeerJ [Category] E형 간염, [키워드] fetal brain malformation microcephaly neurotropism retinoic acid response element (RARE) zika virus (ZIKV) [DOI] 10.3389/fnhum.2016.00403 PMC 바로가기
Whole-exome sequencing is a powerful approach for establishing the etiological diagnosis in patients with intellectual disability and microcephalyResearch Article Published on 2016-02-042023-08-29 Journal: BMC Medical Genomics [Category] E형 간염, [키워드] ASPM BRCA2 CASK DYRK1A ERCC8 KIF11 RAB3GAP1 RNASEH2B RTTN Autosomal recessive inheritance microcephaly whole-exome sequencing [DOI] 10.1186/s12920-016-0167-8 PMC 바로가기 [Article Type] Research Article
Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome중심소체 생합성, Phenocopies Seckel 증후군의 조절자인 마우스 Cenpj의 교란Research Article Published on 2012-11-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Abnormalities addition allele Apoptosis Author Birth Brain cause Cell cell death CENPJ centriole characteristic chromosomal abnormalities chromosomal abnormality chromosome chromosomes clinical feature Clinical features clinical manifestations compared conserved contribute CPAP damaged disorder Disruption DNA damage dwarfism elevated Embryo embryonic embryonic development exhibited expresse expressed feature fibroblast found Frequency Gene genomic growth growth failure hypomorphic immunohistochemistry impairment in addition to Increased J gene lead majority mechanism memory memory impairment Mental mental retardation mice microcephaly mitotic mono mouse Mutation ocular phenocopy proliferation Protein reduced reduction in regulator Seckel Seckel syndrome Signaling skeletal specific mutation specific mutations syndrome wild-type cells [DOI] 10.1371/journal.pgen.1003022 PMC 바로가기 [Article Type] Research Article