Targeted antiviral treatment of hepatitis B virus in culturally and linguistically diverse populations to achieve elimination targets in AustraliaArticle Published on 2022-10-012023-06-12 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] culturally diverse populations Elimination Hepatitis B virus modeling targeted antiviral treatment. [DOI] 10.1111/jvh.13727 PMC 바로가기
Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and DistrictsArticle Published on 2022-09-242022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] affected age analyses applied B.1.1.7 Care coronavirus disease Coronavirus disease 2019 (COVID-19) covariate COVID-19 COVID-19 patient Critical develop discrepancy distribution District Effect epidemiological fatality Germany Government Health health care systems hospital ICU ICU patient Infection Inpatients Intensive intensive care intensive care unit Intervention limit Local management mathematical mathematical model mechanical ventilation modeling National Non-pharmaceutical interventions outcome pandemic patient age performed positive recorded reduce regions reported resources SARS-CoV-2 SARS-COV-2 infection severity Sex Spread state Testing strategy Variability variant Variant of concern (VOC). VoC [DOI] 10.3390/v14102114 PMC 바로가기
Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and BuddingArticle Published on 2022-09-202022-11-16 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] assembly budding caused cellular condensation coronavirus 2 COVID-19 pandemic curtail de novo develop drug target envelope Genome genome condensation genomic RNA host cell identify Infectious virus Interaction intrinsic M protein mechanism membranes modeling molecular Mutation N protein oligomerization pathogen Protein protein intrinsic curvature. Research respiratory responsible resulting RNA SARS-CoV-2 spike structural protein structural proteins the S protein therapeutic target therapy Vaccines viral entry viral life cycle viral particle virus while [DOI] 10.3390/v14102089 PMC 바로가기
Modeling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent RNA Polymerase by DFT/MM-MD: An Unusual Active Site Leading to High Replication RatesArticle Published on 2022-09-122022-11-15 Journal: Journal of Chemical Information and Modeling [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral assist cellular compensated computation COVID-19 diffusion duplication Efficiency Enzymes highlight histidine Inclusion infecting Infection lack leading less Lower lysine mechanism modeling nucleotide Pandemics performed polymerase polymerases Rate reactive reactivity Replication replication of SARS-CoV-2 RNA RNA genome RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 genome Site subsequent the SARS-CoV-2 viral genome Viral RNA virus [DOI] 10.1021/acs.jcim.2c00802 PMC 바로가기
Predictive approach of COVID-19 propagation via multiple-terms sigmoidal transition modelResearch article Published on 2022-09-012022-10-05 Journal: Infectious Disease Modelling [Category] 변종, [키워드] 95% confidence interval affected approach coefficient country COVID-19 COVID-19 pandemic Data analysis determine estimate highest Italy Logistic modeling pandemic Pandemics parameter positive predict provided Result Saudi Arabia Sigmoidal transition SIR Spread spread of COVID-19 variant were used [DOI] 10.1016/j.idm.2022.06.008 [Article Type] Research article
Projected Long-Term Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hepatitis C Outcomes in the United States: A Modeling Study미국의 C형 간염 결과에 대한 코로나바이러스 질병 2019(COVID-19) 대유행의 장기 영향 예상: 모델링 연구Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 치료제, [키워드] analysis Care cirrhosis completion coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic death effort Elimination Epidemic followed by HCV healthcare Hepatitis hepatitis C hepatitis C virus hypothetical Impact Infection infections linkage modeling modeling. outcome outcomes overcome pandemic performed proportion resource return scenario sustained the United State The United States treat Treatment treatment initiation United States [DOI] 10.1093/cid/ciab779 PMC 바로가기 [Article Type] Article
Modeling the Impact of Vaccination Strategies for Nursing Homes in the Context of Increased Severe Acute Respiratory Syndrome Coronavirus 2 Community Transmission and Variants중증 급성 호흡기 증후군 코로나바이러스 2 지역사회 전파 및 변종 증가의 맥락에서 요양원에 대한 백신 접종 전략의 영향 모델링Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] agent booster booster dose Booster vaccine booster vaccines Community community transmission Context coronavirus 2 Coverage COVID-19 cumulative cumulative incidence delta variant dependent on Effectiveness examined home Impact incidence Increased infections modeling Nursing nursing homes outbreak Prevalence respiratory Strategy vaccination vaccination. [DOI] 10.1093/cid/ciac062 PMC 바로가기 [Article Type] Article
Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19COVID-19로 입원하지 않은 성인을 대상으로 한 무작위 시험에서 밤라니비맙의 항바이러스 및 임상 활성Randomized Controlled Trial Published on 2022-08-222022-09-11 Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 1:1 adverse events Antiviral bamlanivimab clinical activity Clinical efficacy COVID-19 symptom COVID-19 symptoms COVID-19 therapeutics evaluated Evidence evidence of faster Inflammatory marker inflammatory markers median modeling monoclonal antibodies monoclonal antibody nasopharyngeal nasopharyngeal viral no differences Placebo Primary outcomes proportion provide Randomized Randomized controlled trial randomized trial reductions in risk risk ratio Safety SARS-CoV-2 RNA Symptom symptom duration undetectable variants of SARS-CoV-2 Viral with COVID-19 [DOI] 10.1038/s41467-022-32551-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents인간 폐 상피 조직 동등물에서 SARS-CoV-2 및 인플루엔자 감염 및 항바이러스 치료 모델링Article Published on 2022-08-122022-09-11 Journal: Communications Biology [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] alveolar Analysis antiviral drug Antiviral treatment antiviral treatments Biomarker cell type cell types cellular chemokine class Critical CXCL10 cytokine Cytokine storm develop emerging viruses epithelial exhibiting human lung IAV IFN response IL-10 IL-6 in vitro in vivo include infect Infection infections Influenza influenza A influenza A virus influenza infection MHC MHC class I modeling Pathogens peaking pharmacological platform Replication robust SARS-CoV-2 SARS-COV-2 infection severe SARS severe SARS-CoV-2 Single-cell RNA sequencing throughput tissue tissues tracheobronchial Validity Viral viral infection virus viruses [DOI] 10.1038/s42003-022-03753-7 PMC 바로가기 [Article Type] Article
Modeling Global COVID-19 Dissemination Data After the Emergence of Omicron Variant Using Multipronged Approaches다각적 접근 방식을 사용하여 오미크론 변이체 출현 후 글로벌 COVID-19 보급 데이터 모델링Article Published on 2022-08-102022-09-11 Journal: Current microbiology [Category] SARS, 변종, [키워드] among others approach basic Behavior collected compartmental model country COVID-19 COVID-19 dissemination COVID-19 pandemic data set data sets determine develop disease spread distribution drop emergence Factor fitting followed by Formula human behavior incidence increase in Infection infection rate infection rates information Interpretation management measure modeling number omicron pandemic reproduction Research Sery Spread statistical text the disease time Transmission vaccination vaccination efficacy variants of SARS-CoV-2 vulnerable population yielding [DOI] 10.1007/s00284-022-02985-4 PMC 바로가기 [Article Type] Article