Comprehensive analytical and clinical evaluation of a RNA extraction-free saliva-based molecular assay for SARS-CoV-2SARS-CoV-2에 대한 RNA 추출 없는 타액 기반 분자 분석의 종합적인 분석 및 임상 평가Article Published on 2022-05-052022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] addition analytical sensitivity clinical evaluation Comprehensive described diagnostic false-negative gold gold standard house individual individuals invasive Laboratory medical staff molecular molecular analysis participated PCR protocol provided repeated RNA RNA extraction RT-qPCR Saliva SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 testing sensitivity shown specificity Standard Swab swabs testing protocols [DOI] 10.1371/journal.pone.0268082 PMC 바로가기 [Article Type] Article
Morphological and Immunopathological Aspects of Lingual Tissues in COVID-19COVID-19에서 혀 조직의 형태학적 및 면역병리학적 측면Article Published on 2022-04-062022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] ACE2 alteration aspect association cadaver caused circumvallate papillae COVID-19 destruction detect detectable died disease disorder downregulated evidenced factor VIII filiform histological analysis histology IFN-γ immunopathological Inflammation Inflammatory lingual lingual papillae loss of taste manifestation molecular analysis Morphological no difference no differences oral manifestations Patient positive processed provided real-time RT-PCR RT-PCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe inflammation severity Signs and symptoms subject Symptom Symptoms Taste taste buds the disease tissue tongue tongue. two groups variety virus [DOI] 10.3390/cells11071248 PMC 바로가기 [Article Type] Article
Skin involvement in early diffuse cutaneous systemic sclerosis: an unmet clinical need Reviews Published on 2022-03-152022-10-05 Journal: Nature reviews. Rheumatology [Category] 바이오마커, [키워드] benefit cardiorespiratory clinical trial clinical trials diffuse disease early diagnosis effective for inclusion gold standard high mortality limitation management measurement molecular analysis outcome measure Patient patients potentially life-threatening progression Quality of life renal Result resulting risk skin Stratification Symptom Systemic sclerosis Treatment [DOI] 10.1038/s41584-022-00765-9 [Article Type] Reviews
Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signalingResearch Paper Published on 2022-02-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, [키워드] activated Activation alveolar inflammation analyzed attenuate cause caused CCL3 change chemokine collagen Coronavirus disease 2019 COVID-19 dihydroartemisinin effective expression fibrosis growth hydroxyproline IL-6 Inflammatory response inhibit inhibited inhibiting inhibitory effect JAK2 JAK2/STAT3 JAK2/STAT3 signaling janus lung Lung injury lung tissue molecular analysis molecular mechanism Necrosis phosphorylated pulmonary fibrosis pulmonary inflammation reduced representing SARS-CoV-2 serum Signaling staining STAT3 TGF-β1 therapeutic therapeutic effect TNFα treat Treatment with COVID-19 worldwide pandemic [DOI] 10.18632/aging.203874 PMC 바로가기 [Article Type] Research Paper
A Community Study of SARS-CoV-2 Detection by RT-PCR in Saliva: A Reliable and Effective MethodArticle Published on 2022-02-022022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acquisition asymptomatic individual Community Concordance Contact tracing convalescent COVID-19 COVID-19 diagnosis detection diagnose downstream effective efficient epithelial Evidence gold standard incidence individual Infection moderate molecular analysis Molecular diagnosis nasopharyngeal Nasopharyngeal swab NP swab oropharyngeal swabs performed population level recruited RT-PCR Safe Saliva saliva test Saliva testing SARS-CoV-2 SARS-CoV-2 detection secretion subjects Support symptomatic individuals tested upper respiratory while [DOI] 10.3390/v14020313 PMC 바로가기 [Article Type] Article
Exploring the Catalytic Mechanism of the RNA Cap Modification by nsp16-nsp10 Complex of SARS-CoV-2 through a QM/MM ApproachArticle Published on 2021-12-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] 2′-O methylation acute respiratory syndrome antiviral therapy approach assumed binding calculated CAP catalytic Catalytic mechanism cellular mRNA complex coronavirus Coronavirus replication Critical Drug discovery enzyme evaluated expected free energy Host innate immune mechanism Methylation molecular analysis mRNA nsp16-nsp10 Nsps PROTECT Protein QM/MM RNA SARS-CoV-2 TS stabilization viral replication virus [DOI] 10.3390/ijms23010300 PMC 바로가기 [Article Type] Article
COVID-19 vs. Classical Myocarditis Associated Myocardial Injury Evaluated by Cardiac Magnetic Resonance and Endomyocardial BiopsyCardiovascular Medicine Published on 2021-12-242022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute SARS-CoV-2 infection baseline biopsy cardiac cardiac function chronic inflammation clinical care CMR Cohort COVID-19 COVID-19 infection COVID-19 patient criteria dysfunction eight EMB Evidence exhibited Follow-up form functional global pandemic healthy volunteer histological impairment Inflammation Lake Louise Criteria LLC magnetic resonance imaging Mild moderate disease molecular analysis Myocardial myocardial injury myocarditis nine Non-COVID-19 non-COVID-19 patient oedema Patient patients with COVID-19 reduced resonance SARS-COV-2 infection serious complication severe disease Symptom symptomatic the disease the WHO ventricular viral infection was performed [DOI] 10.3389/fcvm.2021.737257 PMC 바로가기 [Article Type] Cardiovascular Medicine
Ultrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020초음파 유도 최소 침습 조직 샘플링: 2020년 브라질의 COVID-19 대유행 중 최소 침습 부검 전략Supplement Articles Published on 2021-12-152022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] Accuracy Analysis Autopsies Autopsy autopsy safety biohazard Brazil case sery CDA Complete conducted contribute coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 pathology diagnostic Diseases histopathological identify include infectious agent invasive kidney liver Lungs Microscopy Minimally Invasive Autopsy minimally invasive tissue sampling molecular analysis organ pandemic pathological finding pathology patients with COVID-19 performed polymerase chain protocol provided ranged reduce Result Safe selected Strategy submitted Swab the disease tissue ultrasound guided biopsy were infected [DOI] 10.1093/cid/ciab885 PMC 바로가기 [Article Type] Supplement Articles
Review on Multiple Facets of Drug Resistance: A Rising Challenge in the 21st CenturyReview Published on 2021-12-132022-10-30 Journal: Journal of Xenobiotics [Category] COVID-19, [키워드] Analysis antibiotic Antibiotic resistance Antibiotics approaches Bacteria Bacterial Bacterial infection challenge correlation COVID-19 COVID-19 pandemic Critical database distribution drug drug resistance ESKAPE Evolution excessive use Facet healthcare help in-silico In-silico analysis incidence individual Infection control strategy infections information Interaction life-threatening mechanism molecular analysis molecular mechanism Multidrug resistance multidrug resistant Multiple other diseases pathogen Prevent promoted Regulation Regulatory required Research resistance genes resistance mechanism responsible review SARS-CoV-2 Strains Treatment use of antibiotics [DOI] 10.3390/jox11040013 PMC 바로가기 [Article Type] Review
Identification and characterization of SARS-CoV-2 clusters in the EU/EEA in the first pandemic wave: additional elements to trace the route of the virus첫 번째 대유행 물결에서 EU/EEA의 SARS-CoV-2 클러스터 식별 및 특성화: 바이러스 경로를 추적하기 위한 추가 요소Article Published on 2021-12-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, [키워드] Analysis analyzed Area association circulating Cluster cluster analysis collected Complete confirmed COVID-19 case country COVID-19 dataset early phase element Europe European First wave Frequency identification Italian molecular analysis Mutation mutations nucleotide pandemic Phylogenetic analysis responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 strain single nucleotide SNV SNVs analysis. statistically significant the SARS-CoV-2 virus virus spread [DOI] 10.1016/j.meegid.2021.105108 PMC 바로가기 [Article Type] Article