Intranasal administration of cold-adapted live-attenuated SARS-CoV-2 candidate vaccine confers protection against SARS-CoV-2Article Published on 2022-10-022022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 진단, [키워드] administration animal model attenuate Attenuated vaccines can be used candidate vaccine cleavage COVID-19 COVID-19 pandemic Deletion elicit examined furin cleavage site furin protease glycoprotein hamster hamsters histopathological Host Immunity Infection lesion motif mucosal neutralizing antibody parental pathogenesis of SARS-CoV-2 polybasic protective immunity proteolytic reduce required robust S1/S2 S1/S2 glycoprotein SARS-CoV-2 SARS-CoV-2. sequence Spike protein subsequent suggested unique Vaccine virus wild-type WT SARS-CoV-2 [DOI] 10.1016/j.virusres.2022.198857 PMC 바로가기
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기
Prognostic value of von Willebrand factor and ADAMTS13 in patients with COVID-19: A systematic review and meta-analysisReview article Published on 2022-10-012022-10-05 Journal: Thrombosis research [Category] 바이오마커, 진단, [키워드] ADAMTS13 addition Admission analysis analyzed Antigen cause cleaving Clinical outcome Coagulation Coagulopathy Cochrane Library cofactor coronavirus disease COVID-19 COVID-19 patient Critical database death deficiency defined Effect endothelial injury estimate fixed FVIII ICU immunothrombosis increase indicated intensive care involved Ligand Meta-analysis meta-analysis metalloproteinase Mortality motif no significant difference non-ICU non-survivor outcome outcomes Patient patients with COVID-19 performed plasma poor prognosis Prognosis protease Quantitative random Result risk SARS-CoV-2 searched severe disease course Subgroup analysis survivor Survivors systematic review the Newcastle-Ottawa Scale variable von Willebrand factor vWF Web of Science [DOI] 10.1016/j.thromres.2022.08.017 [Article Type] Review article
3’UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signalingArticle Published on 2022-09-272022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] 293T 293T cell 3’UTR acute respiratory syndrome Alter Apoptosis Bioinformatic Cell cell proliferation cellular processes checked coronavirus COVID-19 cytokine cytokine signaling demonstrated down-regulation drugs growth Host host miRNA human miRNAs IL6 induce inhibit Interaction introduced mechanism miRNA miRNAs motif noncoding RNA overexpressed predicted public health threat reduce reducing regulate Regulation reporter Research SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA SARS-CoV-2 S SARS-CoV-2 spike screened spike gene spike gene. target TNF-α UTR Vaccine virus RNA was determined [DOI] 10.3389/fimmu.2022.924667 PMC 바로가기
Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron VariantArticle Published on 2022-09-212022-11-15 Journal: Clinical microbiology reviews [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory syndrome advance antibodies antibody-based therapies booster characterized Community coronavirus counter COVID-19 disease severity driving effective strategy Effectiveness entry inhibitors Entry mechanism enzyme evade faster fusion inhibitors fusion pathway highlighting immune Immune escape immune evasion Immunity immunotherapies Infection inhibitor inhibitors Innate mitigate monoclonal motif mutated natural infection omicron pan-CoV vaccines Perspective raising resistance. resulting SARS-CoV-2 SARS-CoV-2 Omicron SARS-CoV-2 variant SARS-CoV-2 viral Spread T cell T cell response the SARS-CoV-2 the spike protein Transmissibility Transmission Vaccine vaccine-induced antibody Vaccines variant variants virus [DOI] 10.1128/cmr.00014-22 PMC 바로가기
AIRRscape: An interactive tool for exploring B-cell receptor repertoires and antibody responsesArticle Published on 2022-09-202022-11-15 Journal: PLoS Computational Biology [Category] SARS, 진단, [키워드] antibody antibody repertoire Antibody Response antibody sequence B-cell BCR browser CDR3 comparison Coverage dataset dengue virus Exploratory analyses Github HIV-1 Humoral immunity immune Immunoglobulin monoclonal antibody motif Pathogens Patient receptor repertoire responses reveal SARS-CoV-2 selected sequence Sequencing subset Topology Vaccine [DOI] 10.1371/journal.pcbi.1010052 PMC 바로가기
Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD ProteinArticle Published on 2022-09-182022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 addition affinity angiotensin-converting enzyme 2 antibodies antibody fragment Antibody therapeutics Antigen bi-paratopic VNAR binding binding affinities characterization classical complexes COVID-19 Delta domain epitope exhibited FIVE flexible fusing fusion gel filtration immunized inaccessible motif omicron Protein RBD RBD binding receptor recognize reported SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD Screening shark spike Spike protein the RBD the SARS-CoV-2 variants variants. VNAR wildtype [DOI] 10.3390/ijms231810904 PMC 바로가기
Structural- and Site-Specific N- Glycosylation Characterization of COVID-19 Virus Spike with StrucGPArticle Published on 2022-09-132022-11-15 Journal: Analytical Chemistry [Category] SARS, 치료기술, [키워드] addition Algorithm analyzed characterization COVID-19 COVID-19 virus glycan glycosylation Infection Mannose 6-phosphate mapped motif Previous studies previous study Protein residues SARS-CoV-2 Sequencing spike Structure structures Support the S protein trimer [DOI] 10.1021/acs.analchem.2c02265 PMC 바로가기
The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitnessArticle Published on 2022-09-132022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] anti-viral activity APOBEC APOBEC1 APOBEC3A APOBEC3G Caco-2 cell COVID-19 pandemic cytosine evade Evolution experimental evidence expression Factors genomic RNA Host inhibited Modification motif Mutation mutations new strain Patient progeny promote random Replication RNA SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2 sequence Vaccines viral genome wild-type [DOI] 10.1038/s41598-022-19067-x PMC 바로가기
Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-viralsArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 binding affinity angiotensin-converting enzyme 2 Anti-viral antivirals binding biosynthetic build candidate Cell D614G mutation displaying dissemination EC50 EC50 value fusion protein generate hamsters high stability in vitro Infection Interaction mitigate motif nasal nasal epithelium neutralisation activity neutralization neutralized Omicron variants overlapping promote Protein protein sequence proximal RBD Receptor binding domain recognizing reduced Replication SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants selected targeting the RBD the SARS-CoV-2 trivalent virus virus entry [DOI] 10.1371/journal.ppat.1010799 PMC 바로가기