mouse-adapted SARS-CoV-2 – Page 2 – Communicable Diseases Research

Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19

인간 COVID-19의 대표적인 측면을 요약하는 두 가지 이종 치명적인 마우스 적응 SARS-CoV-2 변이체의 특성화

Immunology

Published on 2022-02-072022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘,

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

ACE2는 TNF- 및 IFNγ-유도 면역병리학을 가진 새로운 COVID-19 마우스 모델에서 SARS-CoV-2에 대한 중요한 생체 내 수용체입니다

Research Article

Published on 2022-01-132022-09-12
Journal: eLife
[Category] 진단,

GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia

Research

Published on 2022-01-062022-10-05
Journal: Nature metabolism
[Category] 치료기술,

SARS-CoV-2 Variants of Concern Infect the Respiratory Tract and Induce Inflammatory Response in Wild-Type Laboratory Mice

SARS-COV-2 관심의 변이체는 호흡기를 감염시키고 야생형 실험실 마우스에서 염증 반응을 유도합니다.

Brief Report

Published on 2021-12-242022-09-10
Journal: Viruses
[Category] SARS, 변종, 치료기술, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptation addition analyzed B.1 B.1 lineage B.1.1.7 B.1.351 C57BL/6 C57BL/6 mice CCL2 change chemokine chemokines Concentration concern Coronavirus-2 COVID-19 cytokine Cytokines evaluated expression greater histopathological Host host-range hosts IL-1β IL-6 Immune escape infecting Infection Inflammation inoculated intranasally lineages lung lung tissue lung tissues Lungs mice mouse mouse-adapted SARS-CoV-2 mRNA level mRNA levels multiple cytokine multiple cytokines Mutation pathogenicity public health replicated respiratory response robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the spike protein These data TNF-α tract Transmissibility upregulated variant variants of concern Viral Viral load viral nucleocapsid protein virulence virus virus viruses wild-type
[DOI] 10.3390/v14010027 PMC 바로가기 [Article Type] Brief Report

Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

마우스-적응 된 SARS-COV-2는 치명적인 SARS-COV 도전으로부터 동물을 보호한다

Research Article

Published on 2021-11-042022-08-13
Journal: PLoS Biology
[Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome coronavirus antigenicity CMA3p20 coronavirus coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID-19 Critical cross-protection disease Economy element generate Heterologous heterologous challenge highlight human airway cell human airway cells human infection human SARS-CoV-2 strains Immune cell infiltration Immunity impair in vivo incorporation lack lung maintain mechanism Mouse models mouse-adapted SARS-CoV-2 mouse-adapted SARS-CoV-2 strains mouse-adapted strain mouse-adapted strain of SARS-CoV-2 Mutation natural infection offer overcome pandemic PROTECT public health Replication Research respiratory reverse genetic system robust SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2–infected mice severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Strains Vaccine variants variants of concern Viral viral replication
[DOI] 10.1371/journal.pbio.3001284 PMC 바로가기 [Article Type] Research Article

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

치명적인 마우스 적응 SARS-CoV-2의 특성 및 구조적 기초

Article

Published on 2021-09-272022-09-10
Journal: Nature Communications
[Category] SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] ACE2 adaptation age Amino acid amino acid substitutions Analysis animal hosts animal model animal models binding affinity cause characterization complex cryo decrease deep deep sequencing ENhance Evolution exhibit generate hACE2 human ACE2 in vivo K417N mACE2 Microscopy molecular basis molecular mechanism Mortality mouse-adapted SARS-CoV-2 Mutation N501Y pathogenicity Pathogens platform provide RBD RBD mutation receptor Receptor binding domain reduce respiratory respiratory symptoms reveal SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 strain Sequencing severe COVID-19 severe respiratory symptoms significantly structural biology the binding affinity the RBD virus Virus-host interactions
[DOI] 10.1038/s41467-021-25903-x PMC 바로가기 [Article Type] Article

Protective Efficacy of Rhesus Adenovirus COVID-19 Vaccines against Mouse-Adapted SARS-CoV-2

쥐에 적응한 SARS-CoV-2에 대한 붉은 털모자 아데노바이러스 COVID-19 백신의 보호 효능

Vaccines and Antiviral Agents

Published on 2021-09-152022-09-12
Journal: Journal of Virology
[Category] MERS, SARS, 진단,

[키워드] Adenovirus adenoviruses animal model animal models Antibody Response binding candidate clinical disease correlated COVID-19 COVID-19 disease COVID-19 pandemic driving Efficacy elicit elicited evaluate evaluated Human immune correlate immune correlates infect Laboratory live vector vaccines Lungs mechanism mice model systems mouse-adapted SARS-CoV-2 Neutralizing antibody titer neutralizing antibody titers probe PROTECT Protective reported respiratory symptoms respiratory tract tissue respiratory tract tissues rhesus robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 virus serotype Support These data to define Vaccine vaccine candidate vaccine candidates Vaccine development vector vectors viral replication virus virus strain wild-type
[DOI] 10.1128/JVI.00974-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents

Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2

Correspondence

Published on 2021-08-252022-10-31
Journal: Cell Discovery
[Category] COVID-19,

[키워드] Cell signalling Increased Mechanisms of disease mice morbidity mouse-adapted SARS-CoV-2 obese
[DOI] 10.1038/s41421-021-00305-x PMC 바로가기 [Article Type] Correspondence

A lethal mouse model using a mouse-adapted SARS-CoV-2 strain with enhanced binding to mouse ACE2 as an important platform for COVID-19 research

Discussion

Published on 2021-05-252022-10-05
Journal: EBioMedicine
[Category] SARS, 유전자 메커니즘,

[키워드] ACE2 binding COVID-19 research mouse-adapted SARS-CoV-2 platform
[DOI] 10.1016/j.ebiom.2021.103406 [Article Type] Discussion

The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract

전임상 억제제 GS441524와 GC376의 조합은 마우스 호흡기에서 SARS-CoV-2의 증식을 효과적으로 억제했습니다

Research Article

Published on 2021-03-192022-09-10
Journal: Emerging Microbes & Infections
[Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity antiviral efficacy blocked caused Clinical studies Combination combined application coronavirus coronavirus disease Coronavirus disease 2019 coronavirus RNA COVID-19 development effective therapy enzyme evaluated global public health GS441524 High-dose inhibited inhibitor intramuscular intranasal low-dose Lower respiratory tract mice mouse model mouse-adapted SARS-CoV-2 nucleotide pandemic pharmacokinetic preclinical inhibitor proliferation protease PROTECT Remdesivir respiratory respiratory tract RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Support synergistic synergistic effect target Treatment
[DOI] 10.1080/22221751.2021.1899770 PMC 바로가기 [Article Type] Research Article